Vision science 3 final

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what do lesions in the vermis cause?4

-esodeviation -varying alignment with orbital position -disconjugacy of saccades -problems with phoria adaptation

What happens to the lens with age? with thickness, ability to change shape, and ability to constrict ciliary muscle

-increase thickness -decrease ability to change shape -remain the same for constriction of ciliary muscle

what are other symptoms to look for when someone has horners syndrome?

-mild ptosis -increase in accomm amplitude -facial anhydrosis (lack of sweating)

how many hz and deg of amp are slow oscillatory movements?

0.04-0.1 hz 0.1-0.2 deg in amp

How much does the lens thicken during accommodation?

0.5 mm

what is the true statemtent regarding Vestibular OK interaction? none velocity storage only OKN and rotary opposite movements OKAN and post rotary nystag in the same directions

NONE

Does pendular nystagmus have fast and slow phases?

No

Is all nystagmus abnormal ?

No

Is there oscillopsia with Congenital nystagmus?

No

What is rebound nystagmus ?

Nystagmus at central gaze after prolonged eccentric fixation

What is rebound nystagmus?

Nystagmus at central gaze following prolonged eccentric fixation

What is Alexanders law and does periph vestibular nystagmus obey it?

Nystagmus in increased in the direction of the quick phases Quick=larger

What is end point nystagmus?

Nystagmus occurring in extreme lateral gaze / eccentric gaze

what other nucleus is the edinger-westphal nucleus next to?

OMN

What are the kinds of physiological nystagmus ?

Okn an okan Vestibular nystagmus and vestibular after nystagmus End point nystagmus Rebound nystagmus

How many planes is pathological nystagmus in?

One or more

What directions Are the fast and slow phases going in? Same or opposite

Opposite

What can also come with pathological nystagmus

Oscillopsia

What else comes with acquired pendular nystagmus?

Oscillopsia

T/F reflex blinks can be conditioned with a noise and a puff of air

True get sound and will blink wont even need air anymore

While medulla, pontine, and midbrain lesions are associated with what type of nystagmus?

Up beat

What are the types of beating that can happen with central vestibular nystagmus?

Up beat Down beat Or torsional Or any combination

what must be negated during an initial head movement but must switch back on upon reaching the gaze goal?

VOR

What if the pathological vestibular nystagmus is central in origin? It indicates that there is dysfunction in what?

VOR pathway Including vestibulocerebellum or brainstem VOR structures

what are combined head and eye tracking and tracking a head-fixed target an example of?

VOR-SP interaction

What is another feature that is a distinguishing feature of nystagmus?

Velocity of the slow phase

What happens in periodic alternating nystagmus?

Vestibular nystagmus where the direction changes every 90-120 sec

What kind of nystagmus shows a linear slow phase?

Vestibular nysyagmus

_________-____________ is most often implicated in downbeat nystagmus

Vestibular-cerebellum

Does central vestibular nystagmus obey alexanders law?

Yes - nystagmus in increased toward the side with the quick phases

why is there so much research going into the IOLs?

ability to constrict ciliary muscle remains the same

if you want perfect yoking, what should equal what?

ac/a=pupillary distance

what does binocular viewing improve?

accomdation- cross linking conv and accomm

The subject must engage in what kind of mechanisms to clear up the blur?

accommodation

What is necessary for changing focus on viewing a near object?

accommodation

cells encoding vergence in more central areas such as the cerebellum, brainstem, and cortex also appear to encode what?

accommodation

stimulation of a local region of the EW nucleus can produce what without pupil constriction?

accommodation

The EW nucleus and ciliary ganglion are important structures for which of the following functions?

accommodation and pupil control

What happens to accommodation during presbyopia (aging)?

accommodation capability reduces continuously through life

what happens in myopes with accommodation?

accommodation lag- dont accomm as much as 'demand' requires

blur stimulus can drive vergence via what type of crosslink?

accommodation-vergence

how can a blur stimulus drive vergence?

accommodation-vergence cross link

Blur drives a form of vergence called what?

accommodative vergence or blur vergence

What does the obicularis do?

active closure of the eye

what does it mean to eat the prism?

adapt to it - in phoria adaptation

Q What are the different ways to measure stability of fixation? -estimate the bivariate contour ellipse area during fixation -evaluate microsaccade freq and amplitude during fixation -evaluate drift amplitude and velocity during fixation -all of the above -none of the above

all of the above

Q fixation includes the following kinds of eye movements -drifts -small saccades less than 1 deg (microsaccades) -high frequency oscillations about 30-100hz (tremor) all the above none of above

all the above

what happens to the vision when the lens flattens ?

allowing for distance viewing and long range of focus

what happens to the vision when the depth of focus increases? and what happens to the tolerance of accomm error

allows for clear vision for more widely spaced objects and allows for MORE tolerance of accommodative error

does the normal or amblyopic eye have more domination of microsaccade rate?

amblyopic has less microsaccades than the normal rate

What does the ACA ratio describe?

amount of accomm convergence in prism diopters that happens when the eyes accommodate 1 diopter (-/+)

What is hofstetters rule?

amplitude = 18.5-age/3

what does approaching looming and going further looming cue?

approach means near further means farther

much of the activity involved in fixation involves movements on the scale of a few_____________?

arc min

what is the average size of a microsaccade and what is the size that it doesnt exceed ?

avg is 0.25 deg (15 arc min) dont get larger than 1 degree basically very small eye movements

what are the conditions that tonic vergence takes place?

awake

What is proximal vergence?

awareness of near

what happens at near VOR?

background shakes

BALANCED activity across both SC results in _______________. imbalance leads to _________________

balanced- fixation imbalance- microsaccade

the obicularis oculi also gets innervation from ___________ and other subcortical structures for control of spontaneous and reflex blinking , and emotional expressions of the face

basal ganglia

what do cortical defects cause?

bilateral ptosis

ocular misalignment can be viewed within a framework of what type of control of eye movements?

bincocular control

what is fine tuning pursuit of binocular position after a fast component and static alignment mostly connected with? what kind of circuit

binocular hering

in addition to eye misalignment, what else is disrupted in strabismic humans and monkeys?

binocular coordination of eye movements

What kind of vision does someone need for retinal disparity?

binocular vision

What is BCEA?

bivariate contour ellipse area

What is the disorder under excessive closure?

blepharospasm

what is due to an ocular dz which irritates cornea, such as dry eye uveitis or keratitis?

blepharospasm

what is the best driver of vergence when put together?

blur and disparity

what is the stimulus for vergence ?

blur and disparity

what is the pathway of blur?

blur goes to phasic accomm and then crosses and continues straight to tonic vergence and then to accomm

cells in the pretectal nucleus project to one or both EW nuclei via the posterior commissure?

both

on extreme downgaze, what happens to the activity of the superior rectus and levator activity?

both cease entirely almost

A patient has a unilateral lesion of the left fastigial nucleus what is the affect on the saccadic eye movements?

both eyes overshoot, left saccades and undershoot in rightward saccades

what muscles are activated when the eyelids are relaxed ?

both muscles have low activity and lids close due to reducing tone of the levator which normally keeps lids raised

what 2 adaptations take place in the disconjugate adaptation?

both saccadic and vergence components

what does looking at an eccentric target require generation of?

both vertical vergence and cyclovergence

electrical stimulation of a single site in the intermediate and deep layers of the SC with the eyes at different starting locations results in a what?

constant amplitude gaze shift

what happens at the end of the 4 neuron arc pathway?

constrict iris muscles

Q: in horners syndrome pupil constriction is what? and pupil dilation is what? normal or abnormal

constriction is normal dilation is abnormal

the obic oculi receives primarily ______projections from the motor cortex for voluntary control of blinks and eye closing

contralateral

what is the pupil control pathway parallel to?

control of accommodation

what is faster, convergence or divergence?

convergence

What is the near triad?

convergence is accompanied with accommodation and miosis

a disparity stimulus can drive accommodation by what kind of cross link?

convergence-accommodation

disparity stimulus can drive accommodation via what cross link?

convergence-accommodation cross link

What happens between vergence and accommodation control systems?

cross coupling

What does the vergence and accomm cross coupling models do?

cross the information in the blur-accomodaiton and disparity-vergence pathways

Amblyopes exhibit increased of decreased microsaccades? increased or decreased drifts ?

decreased microsaccades increased drift

what happens to the radius of curvature of the anterior and posterior surface of the lens during accommodation?

decreases

what is the measure of the angular movement of the eye?

degrees

What are the 3 different vergence measures?

degrees prism diopters meter-angles

movements of the left and right eyes made in response to a stimulus that changes in both _________ and ___________ is a simple sum or difference of separately generated vergence and conjugate movements

depth and conjugate position

How do you calculate the calculated ACA?

determine range of phoria at near and distance and then divide by the distance viewing

When do you get vergences? viewing objects at ______?

different distances

what is the regression movement usually associated with?

difficult passages and uncommon words

what system controls dilation and which controls constriction?

dilation-sympathetic constriction- parasympathetic

binocular anomalies at near can produce ___________ and interfere with reading , even in individuals with normal monocular vision

diplopia

What does monosynaptic mean?

directly send signals to the medial rectus

What type of adaptation happens with anisometropia?

disconjugate adaptation

what is the pathway of the disparity pathway?

disparity to phasic to crossing and straight to tonic and then vergence

if you were ranking vergence drivers in descending order of importance, which of the following would be an appropriate sequence?

disparity, blur, looming, size cues, awareness of near

fixation is _____________ whenever inappropriate eye movements occur on attempted steady gaze

disrupted

how are the 2 images focused and separated?

distance and vertically separated so that the 2 images dont interfere with each other

because the voluntary and involuntary pathways are _______, one can show deficiets which affect voluntary blinks but not reflex blinks and vice versa

distinct

BCEA measures dispersion of _____________ and _______________ eye positions during fixation

horizontal and vertical

What syndrome is a loss of sympathetic innervation to the eye, caused by damage at central levels (hypothalamus) ganglion levels or to the nerve itself?

horners syndrome

where do the preganglionic signals arise from?

hypothalamus via the cervical spinal cord

When we looked at the grid of all black squares at the black dot and then the white dot, what did we see?

image shift

where are vergence cells found in the superior colliculus?

in the rostral SC

it appears that the context of viewing a near target causes an increase or decrease in VOR gain?

increase

what does pupillary constriction helps to increase to reduce amount of accommodation needed?

increase depth of field

what may be the cause of presbyopia?

increase stiffness of the lens with age

What happens to depth of focus as the pupil gets smaller?

increases

standard deviation of fixational eye position are largely independent or dependent of stimulus parameters?

independent

what is the sympathetic innervation providing ?

inhibition needed for a push pull system

what does divergence speed depend on?

initial vergence position

what is the reading eye movement that is a small saccade which takes the eye from one fixation to the next?

inter fixation saccades

Converting MA to degrees depends on what value?

inter-pupillary distance

Which of the following disease conditions could be used as supporting evidence for herings framework for binocular control?

internuclear ophthalmoplegia

what kind of eye movement is showing when someone cant do conjugate eye movements to one side but is able to do vergence abduction?

internuclear opthalmoplegia

reflex blinks can occur involuntarily or voluntarily and concious or unconcious?

involuntary unconciously

What controls the obicularis oculi?

ipsilateral facial nucleus in the brainstem

what is the question of interest when it comes to eye movement responses?

is it the sum of individual responses or are there more complex interactions in the brain?

why is it important to formalize the link between vergence and accomm?

it helps understand the neural control and helps understand disorders

what does having a catch up saccade during a SP do to help?

it improves the accuracy of the eye movement making it optimal and not guessing where the object is at

why is fusional vergence better?

it is faster -is the sum of the direct combination of accomm and convergence -also improves with binocular viewing because of the crosslink

what does binocular and monocular horizontal line take out of the situation?

it takes out the disparity- the horizontal stick will look the same no matter if it is coming toward or going away from you if cant see ends of the stick

what happens to the pupil size when it is having light adaptation?

it will change from a 2mm-8mm and makes a 16 fold change in the light entering the eye

what is the cause of essential blepharospasm?

its idiopathic

why is the response larger than the sitmulus aca?

lag of accommodation

do voluntary blinks have large or small amplitude and last shorter or longer than reflex blinks?

large amp longer lasting

What happens with the size of fixational movements when there is a larger object? small object?

larger fixation movement smaller fixation movement

The muscle planes for the right inferior and superior recti are roughly parallel to?

left posterior semicircular canal

What happens with the lens vertically during accommodation?

lens drops slightly under influence of gravity

what changes in the anatomy during accommodation?

lens shape (thicken)

what part of that beetles eyes is the bifocal?

lens- middle and periphery regions have diff powers

are these cues less or more effective drivers?

less effective

why is there fading in the amblyopic eye?

less microsaccades to make it a fresh stimulus in the problem eye

in primary gaze, what muscle must maintain constant tone to keep the upper lid elevated?

levator

what is the muscle that elevates the upper lid and what innervates it?

levator 3rd nerve

Q The ____ muscle is responsible for keeping the eyelid elevated and the _______ muscle is responsible for active closure during a blink

levator obicularis oculi

What happens with the levator and Obic oculi during a blink?

levator inhibited obicularis activated

What are the muscles involved in blinks?

levator palpebrae mullers muscle frontalis muscle

what muscle remains activated througout a WINK and what one can turn on an off?

levator remains active can control one obicularis oculi and increase force above the levator

What is it when eyelids fail to lower as gaze is lowered?

lid lag

VOR gain is better in the __________ (with OKN) than in ________________ (without OKN)

light dark

what accounts for most of the interaction? is that true for all interactions?

linear superposition NO there are nonlinear effects as well

Precision of fixation varies a lot or a little with stimulus parameters?

little

what is a square wave jerk?

look away from the target and then back to the target

what happens when there is high frequency of motion?

lots of retinal slip

Infants have a high or low blink rate?

low

what does pseudo ptosis mean?

low hanging lids

what is a common ocular disease that causes a central scotoma and eccentric fixation?

macular degeneration

what does a peak lid velocity result in?

main sequence for lid closure

Why do we blink?

maintenance of tear film removal of foreign bodies protection from looming objects

How does the brain generate eye movements in depth (3-D)?

making movements in depth- two eyes are moving diff amounts

what horners syndrome the first sign for?

malignant tumor

Where are the disparity sensitive cells found?

many cortical areas! v1,v2, v3, v3a, MT, MST, LIP

What is measures the effort for vergence?

meter angle

a 1 yr old child and a 25 yo adult are viewing an object 25cm in front of their eyes. which of the following methods express their vergence angle would be the same in the 2 subjects ? degrees prism diopters meter angle a,b abc

meter angle independent of PD

What is the amount of convergence required to view an object at 1m?

meter-angle

What eye movement is the only 'good' idea of a mechanism that is underlying fixaitonal eye movements?

microsaccades

what part of the brain is the SOA in?

midbrain near response cells

there is evidence that the saccadic system is able to use ____________ to encode the ____________ of the catch up saccade

retinal slip velocity amplitude

what is the reading eye movement that is a large saccade which take the eye to the beginning of the next line of text?

return sweeps

where are the neurons located in the brain that encode microsaccades?

rostral collilculus

what type of interaction are catch up saccades having?

saccade-SP

during scanning eye movements, a series of ___________ are made in order to inspect a scene

saccades

eyes scan a line of text with a series of ___________ during reading

saccades

stimulation of the rostral fixation zone of the SC seems to suppress vergence in addition to what?

saccades

what kind of eye movements do blinks facilitate?

saccades

what are microsaccades used for?

scanning

What kind of transformation is required to generate vergence motor commands from sensory disparity signals?

sensorimotor

how does a cat, racoon, lamprey change focus?

shifiting in lens position

the peak velocity of fast vergence eye movements is ______________ the peak velocity of the similar amplitude saccadic eye movements

significantly slower than saccade is 800 and vergence is 100

neural recordings in the PPRF during asymmetric vergence suggests that these cells encode movements of what instead of conjugate signal?

single eye

what are the cues that help drive vergence eye movements?

size texture looming (motion)

___________ and ___________ matters- higher stand dev for disk targets and larger targets

size and shape

does phoria adaptation have a slow or fast adaptive process?

slow

Normal regressions tend to be larger or smaller than the inter-fixation saccades that preceed them?

smaller

What rate and amp does the high freq tremor of the eyes have?

smallest amp rate of 30-100 hz

One hypothesis was that fixation was simply _______________-_________ (gaze holding eye movement) at zero velocity

smooth pursuit

The saccadic system can respond to positional retinal error during ______________________.

smooth pursuit

what is slow vergence neccessary for? kind of eye movement

smooth pursuit

when slow drift creates errors, are they only bad errors or some are good too?

some toward object and some away from object

saccades speed or slow the ongoing vergence movement suggesting that that the brain does or does not simply process conjugate and vergence errors separately

speed up does not

release of tension of the zonular fibers causes the lens to become more?

spherical

What kind of blinks are made without any specific stimulus or effort?

spontaneous blinks

what does the eye movement trace during reading represent?

staircase

what is the aca that compares the convergence to the accommodative stimulus (diff from the response) ?

stimulus aca

what condition makes herings hypoth fall apart?

strabismus- losing BV and 2 eyes are NOT tied together as one

When an object is brought closer to the subject, it appears blurry because why?

subject is focused behind the object

where does the sympathetic nerve fibers ascend from?

superior cervical ganglion at the base of the skull

what is the better and main way to cancel out VOR? which of the 2

superposition of the VOR and SP signals

what part of the cortex is important for predicative vergence eye movements ?

supplemental eye fields

OKN ______________ VOR at _________ frequencies

supplements low

What part of the brain is responsible for the vergence signals?

supraoculomotor area (SOA)

What is the alternative theory called? is there much evidence for the theory?

tension theory no

what does this prove if only vergence is possible?

that there is a separate pathway for vergence and conjugate eye movements

what does the pupillary light reflex control?

the diameter of the pupil in response to light intensity

how do the ellipses of horizontal vs vertical eye movements change as it goes from normal to strab viewing eye to strab deviated eye?

the ellipses get bigger from normal to strab viewing to strab deviated

what does this light adaptaion allow for?

the eye to adjust for changes in light level

is the gain higher or lower with SP movements in an eccentric location verses being straight ahead?

the gain is lower in the eccentric position

why does the head take longer to turn in the head-eye saccades?

the head is heavier and has more INERTIA

if retinal disparity is non-zero, what does it mean?

the image is falling on a Non Corresponding retinal areas

what happens when the ciliary muscle causes the zonular fibers to become taut?

the lens flattens

what is vision controlled by?

the lens which is controlled by the suspensory ligaments and ciliary muscle

where is the CCN near by?

the oculomotor nucleus (that controls SR)

what happens when the choroid is pulled forward ?

the retina is stretched slightly

what do the 'steps' represent?

the saccades

what happens with the zonular fibers during accommodation?

the tension is released

what does the longer latency mean for accommodation in older people?

the time to accommodate will take longer

Does congenital nystagmus increase or decrease with attention or fixation?

Decease

T/F in peripheral vestib nystagmus the other eye movements are not reserved

False they are

What is the jerk nystagmus described by? Which direction, of the slow or fast phase?

Fast

What makes up a jerk nystagmus ?

Fast phase and slow phase

What does a right beating nystagmus have?

Fast rightward phase and slow leftward phase

What is the resetting phase? Fast or slow?

Fast that's why we care more about the slow phase

What can the peripheral vestibular nystagmus be suppressed by?

Fixation So to tell is by testing PVN by removing fixation

What is the purpose of the head turn or head shake?

For the null to be straight ahead

_________ periods are periods during the waveform when the eyes are still, vision is acquired during these periods

Foveation periods Keeps the image stable

What kind of nystagmus shows an exponentially decreasing slow phase?

Gaze evoked nystagmus

What comes with INS/CN?

Head shaking or head turn

What are the 3 components for acquired pendular nystagmus?

Horizontal vertical and torsional

Where does the problem tend to show up in the cerebellum when they have periodic alternating nystagmus?

In the nodulus or uvula

Nystagmus increases or decreases intensity with gaze eccentricity?

Increases

What is another name for congentialy nystagmus?

Infantile nystagmus syndrome

Where does the fastigial nucleus and posterior interposed nucleus project to?

SOA

what responses are added to get an eye movement for cancellation?

SP response+VOR response

What kind of nystagmus does someone have if they have vertical disjunctive component and conjugate torsional component?

Seesaw or hemi-seesaw nystagmus

What if the pathological vestib nystagmus is peripherial in origin? That means there is a dysfunction in what?

Semicircular canals Otoliths Or vestibular nerve

What does pathological nystagmus lead to?

Slip of images on the retina

________ phases may be linear, increasing or decreasing velocity

Slow

________ ___________ is a disorder affecting infants and young children. It involves rapid, uncontrolled eye movements, head bobbing, and sometimes, holding the neck in an abnormal position

Spasmus nutans

What are the pathological nystagmus associated with specific what 2 things?

Specific eye disease Specific eye movement systems

what encodes the desired gaze displacement?

Superior colliculus

T/F cells that are in the SOA that encode vergence also encode accommodation

TRUE

T/F in addition to disparity and blur, other cues may help drive vergence eye movements

TRUE

T/F in the real world, eye movement stimuli are varied and do not stimuluate only one type of eye movement system

TRUE

T/F rapd can appear as paradoxical dilation of pupils when light is presented to bad eye after normal constriction due to presentation of light to the good eye

TRUE

T/F there are changes in both vergence and conjugate positions in movements of depth

TRUE

T/F vergence is highly adaptable

TRUE

T/F we blink to help visual motor coordination?

TRUE

where does the NRTP project to?

vermis and directly to the FN/PIN

what is an example of a near anomaly in a normal monocular vision pt?

vertical phoria - they can lose their place at the beginning of a line of text

what is used to compensate for vertical phorias?

vertical vergence and cyclovergence

what two things must interact to get the gaze on the target?

vestibular response and the head response

amblyopia, RE, presbyopia are examples of causes of reading difficulty because they have a loss of?

visual clarity

why dont people notice spontaneous eye blinks? what 2 principles

visual masking effects and visual suppression effects

What blinks are made on command?

voluntary blinks

square ________ ___________ occur occasionally in normals

wave jerks

what times will the cancellation not work?

when the head is still and the target is moving at high frequencies

why is the calculated greater than the gradient aca?

will take into account proximal vergence

symp nerves pass through the ciliary ganglion with or without synapsing?

without

can inter-fixation movements jump over the first part of a word or several words?

yes

is the degree range adaptable/ plastic with shrinking and expanding the ranges with only eye movements or head only?

yes

Are microsaccades intentional movements?

yes - they are not random

is vergence still possible when the MLF (Hori eye movements) is lesioned?

yes because it doesnt control vergence

are large saccades encoded here?

yes just more caudal

can this happen the other way where pupil constriction can happen without accomm controlled by the EW nuc?

yes!

young pts with central scotomas tend to develop more stable ________, while older patients tend to be more __________

young-stable PRL older -variable PRL

what is the tension on the lens caused by?

zonular fibers

what is the velocity of fixation?

<4deg/sec

smooth pursuit has a limited range of ___________deg/sec and a ______ latency to sudden changes in target velocity

<90 130 msec

What is pathological nystagmus?

A disorder of eye movement control associated with a variety of conditions

what determines the strength of this crosslink of the blur stimulus?

ACA ratio

what is the strength of the accommodation-vergence crosslink defined by?

ACA ratio

if the near phoria=far phoria, then what other things are equal?

ACA=PD

Pathological nystagmus can be either congenital or ——-

Acquired

During eye-head saccades... -eyes move forward -VOR is negated for movement prior to attaining gaze goal -head stops after gaze Goal is reached -VOR kicks in once gaze goal is reached -all of the above

All of the above

Where are the lesions around when someone has jerk or hemi-seesaw nystagmus?

Around the interstitial nucleus of CAJAL (vertical)

Where are the lesions when someone has pendular see saw nystag?

Around the optic chiasm and will cause pendular seesaw

Someone with vestibular and gaze evoked nystagmus develop what in order to see clearly?

Develop head turn so the null eye can see clear

Often pathological nystagmus are of ——- value

Diagnostic

Convergence and head posture has or doesnt have an effect on ventral vestibular nystagmus?

Does have

What direction is the fast phase in downbeat nystagmus?

Downward is the fast phase e

what do the cues do then?

fine tune binocular eye position following vergence eye movement

What muscle is the antagonist of the levator?

obicularis oculi

what happens with obicularis and levator at the end of a blink?

obicularis shuts down levator resumes former tone both cant contract

High resolution recording of oculomotor activity reveals that the eye moves also during these periods. The line of sight continually wanders with a seemingly random trajectory called _________________ occasionally interrupted by saccades with small amplitudes called ___________________________.

ocular drift microsaccades

why does does someone only use eye movements in the 35-40 range?

ocular motor performance deteriorates when the eye is eccentric in the orbit

the responses to these stimuli are also complex involving more than one __________________ __________________

oculomotor sub-system

What is the peak velocity of a blink?

on the order of saccadic peak velocity -800deg/sec

the beetle has 2 retinas, how are they arranged?

one behind the other so that the sharp image from each lens region falls onto a diff retina

what does the obicularis oculi muscle surround? what action does it have?

palpebral fissure sphincter action

what system innervates the ciliary muscle?

parasympathetic

What are some other disorders in fixational control

pathological intrusions nystagmus

what is the aca ratio that compares the convergence to the actual accommodative response ?

response ACA

what is tonic vergence?

resting state of vergence

What are the 2 stimuli to vergence?

retinal disparity and blur

what is the stimulus for OKN?

retinal slip due to LARGE field stimulus

what is the stimulus for smooth pursuit?

retinal slip velocity

how many mm is the SOA dorsoalateral to the oculomotor nucleus?

1-2mm

What is the hz that is for acquired pendular nystagmus ?

1-8 pendular waveform

why does the black dot stay visible?

1. receptive field is very small- shifting gaze slightly will see on new recep field 2. fixational eye movments are switching fields

what is the 4 neuron arc steps of pathway for the pupillary light reflex?

1. retinal ganglion cells 2. via optic nerve, the pretectal nucleus 3. EW nucleus 4. via oculomotor nerve- the ciliary ganglion

what are the 2 ways to cancel out VOR ?

1. superposition SP and VOR signals 2. reduction in head movement sensitivity -from canals in ear

what percent of all inter fixation movements is regressions?

10%

how large in arc min are slow drift movements?

10-15 arc sec

what is the amplitude of levator excursion from downgaze to upgaze ?

12-17 mm

what is the typical spontaneous blink rate per min?

15-30

how many log units does the light on the retina change by?

2 log units for a 250 msec pattern

what is the infant blinks per min?

2 per min

Where are the quick phases directed in peripheral vestibular nystagmus? Away or towards the lesion?

Away from the side of the lesion So slow towards the lesion

How long is the duration of a typical blink?

200-400 msec covers pupil in half that time

What is the latency of vergence eye movemets?

200msec

What is the latency for the lid when having irritation or sudden loud sounds?

25msec

how many classifications are there for horners syndrome?

3

what is the equivalent degrees for a 6cm interpupillary distance?

3.4 degrees

under normal conditions of visual scanning, humans tend to use their eyes only within a range of ________________ degrees

35-40 degrees

what type of movements are made from saccade vergence interactions?

3D movements

how many different disorders of lid control are there?

4

how many neurons are there in the 'arc' for pupillary light reflex?

4

What is the typical amount of arc min for drifts/sec?

45 arc min

what is the length in arc min between ocular drifting during fixation - making microsaccades between

5- 10 arc min

how many pairs of eyes does a diving beetle larva have?

6 pairs 1 primary and the rest bifocal abilities

What percent of your waking day is with your eyes closed if each blink is 1/4 sec?

6-12%

what percent ellipse is formed from the BCEA?

68% confidence ellipse

what percent of reading time is spent in fixation periods?

90%

what percent of the inter fixation saccades are left to right movements?

90%

How large are microsaccades in deg?

<1deg

Q: which of the following statements about interactions between eye movement systems are true? -there is no interaction between eye movement systems -most interaction can be explained by linear suppression -there is evidence for nonlinear interaction between system -all of abc -b and c

B and c

Which of the following experimental observation provided evidence for non linear interaction between saccade and vergence systems - peak velocity of the vergence component saccade vergence movement is equal to peak velocity of a similar amplitude vergence only movement -peak velocity of the vergence of combined component saccade vergence movements is less than peak velocity of a similar amplitude vergence only movement -peak velocity of the vergence component of a combined saccade vergence movement is greater than peak velocity of a similar amplitude vergence only movement -lesion of the MLF affects saccadic movements but not vergence -vergence related neural responses can be found at several areas in the brain adjacent to saccade related neural responses

C similar amplitudes

the strength of the crosslink of the disparity stimulus is defined by what?

CA/C ratio

what is the strength of the convergence-accommodation cross link defined by?

CAC ratio

what does the fastigial nucleus have neurons related to?

CONvergence

for the cac ratio, what must equal to get perfect yoking?

Ca/c = 1/pd

Is congenital nystagmus developed during infancy or born with?

Can be either-why they changed name to infantile nystag syndrome

What kind of nystagmus shows a exponentially increasing slow phase?

Congenital nystagmus

Is pathological nystagmus conjugate or disconjugate?

Could be both

Will pathological be peripheral or central in origin?

Could be either

what does the post interposed nucleus have neurons related to?

DIvergence

For gaze evoked nystagmus, it should be differentiated from end point nystagmus and one way to tell is what?

Exponentially decreasing slow phase that is directly towards the center (fast away from the center)

T/F blinking does not help people with oculomotor apraxia (paralysis of voluntary gaze control) initiate saccades

FALSE

T/F return sweeps start at the LAST character at the end of the line and the FIRST character at the beginning of the next line

FALSE start a few charaters from the end and then a few past the first in the next line

T/F aca and cac are ratios that are dependent on each other

FALSE they are independent of one another

T/F the head stops after the gaze goal is reached

FALSE it keeps going

T/F you can voluntarily flex one levator muscle and cant contract just one obicularis oculi

FALSE opposite

T/F microsaccades are driven through a different circuit than normal saccades

FALSE same circuitry

T/F blink rates remain pretty constant across individuals and tasks

FALSE they vary

vergence neurons are adjacent to the saccade neurons in the?

FEF

where in the cortex is vergence eye movements signaled?

FEF- frontal eye fields SEF -supp eye fields

Is the nystagmus different in the two eyes?

It can be

Why do we label it by the fast phase if the slow phase is what is more important?

It is easier to see by the clinician

What does a mixed nystagmus waveform look like?

It is mixture of sine wave and jagged peaks

What does a jerk waveform look like ?

Jagged mountains

What are the 3 types of waveforms that are distinguishing features of nystagmus?

Jerk Pendular Mixed

Vergence position = ___ position - _____ position

LE position - RE position

what is the equation for vergence?

LE postion-RE position

What is another name for fusional maldevelopment nystagmus syndrome?

Latent nystagmus

On what gaze is nystagmus observed on?

Lateral gaze

What does a gaze evoked nystagmus indicate about the brain processes?

Leaky neural integrator function - inability to maintain eccentric gaze

What is a telling sign in peripheral vestibular nystagmus?

Linear slow phase

What is acquired pendular nystag associated with? What diseases?

MS And oculopalatal myoclonus

Is INS/congenital nystag mainly horizontal or vertical with smaller horizontal or vertical/torsional components?

Mainly horizontal with smaller vertical and torsional components

What does the waveform look like for congenital nystagmus?

Mixed pendular and jerk

Does the head and eye start at the same time in eye head saccades?

NO

are the tremors correlated in the 2 eyes?

NO

Is central vestib nystagmus well suppressed by fixation?

NO That's peripheral

there is a constant amplitude gaze shift, but are all the combinations of eye and head amplitudes the same as well?

NO they are different

What is a common muscle palsy that have reading diffculties because they cannot __________ adequately

SO can depress adequately

OKAN tends to cancel out what?

PRN dancer doing turns

A general term for nystagmus caused by imbalance in push pull vestibular system is what?

Pathological nystagmus

- —- ———— is Normally occurring eye movement designed to keep the eyes within a normal working range

Physiological nystagmus

What does the R and L colliculus control?

R controls L movement L controls R movment

What is the equation for conjugate RE and LE movements?

RE+LE/2 the average of the 2

Is a purely horizontal nystagmus rare or common?

Rare for central vestib nystag

What is nystagmus?

Repetitive to and fro movement of the eyes is defined as nystagmus

What does a pendular waveform look like?

Rolling hills or sine wave

Alexanders law states that interaction between vestibular nystagmus and gaze evoked nystagmus is what?

The nystagmus is null on one side because they cancel out and increase in nystagmus more eccentrically to the other side because they add together

where does the fastigial nucleus and posterior interposed nucleus recieve projections from?

vermis

What is the goal of physiological nystagmus is what?

To keep the image slip small

What type of suppression follows a saccade in acquired pendular nystagmus ?

Transient - nystag will dampen then come back

what ratio do you use when vergence stimulates accommodation?

ca/c ratio

What is the ACA ratio that is determined from the phoria measure at far and near using an equation?

calculated

which is normally a higher value, calculated aca or gradient aca?

caluculated

are the drifts conjugate or disconjugate

can be both -combo of vergence and versions

during CEHT (combined eye head tracking) or HFT (head fixed tracking) the VOR signal is counterproductive and must be __________?

cancelled out

what are the incidences of the central preganglionic postganglionic in percents?

cent- 13% pre-44% post-43%

What nucleus controls the levator?

central caudal nucleus via the oculomotor nerve

what is the hemholtz framework when it comes to depth movements?

central parts of the brain are developing commands for each eye independently like a chameleon

What is the hering framework when talking about brain generations of seeing depth movements?

central parts of the brain are developing commands for the conjugate and vergence SEPARATELY

Eccentric fixation happens when patients have a what?

central scotoma

what are the 3 classifications for horners syndrome? think in regards to a nerve

central, preganglionic, postganglionic

how does an eel change focus?

change its axial length

how does an owl change its focus?

change its corneal shape

humans and non human primates change focus how?

change lens shape

what does the sympathetic innervation pass directly?

ciliary ganglion

what ganglion and nucleus are important in the accommodation control?

ciliary ganglion and ed westphal nucleus

Q: what happens with the ciliary muscles and the zonular fibers during the relaxation theory?

ciliary muscles contract and zonular fibers become less taught

Where do the vergence cells lie close to in the nucleus reticularis tegmenti pontis (NRTP)?

close to the smooth pursit and saccade cells

what does larger in size cue?

closer

the amount and duration of dimming are reduced in our perception so the gap is doing what?

closing in

even though the levator neurons project to only one eyelid, they are ______________ in the CCN and therefore achieve bilateral control of eyelids

co-localized

what is excessive retraction of the lids on attempted upgaze?

colliers sign

what are the 2 disorders that are under excessive opening?

colliers sign lid lag

What is BCEA used to measure?

common method to measure fixation stability

there is a lot of evidence that interaction between eye movement systems is ____________

complex

under herings framework for binocular control, the brain processes _______ and __________ eye movements separately

conjugate , vergence

what can any 3d movement be broken into?

conjugate and vergence parts simultaneously

vergence is an independent eye movement subsystem and is controlled separately from what kind of eye movements?

conjugate eye movements such as saccades

which muscle is conjugate and which one can be controlled monocularly?

conjugate is levator monocularly is obicularis oculi

slow oscillatory movements are __________ vertically and ___________ horizontally (conjugate or disconjugate for both)

conjugate vertical disconjugat horizontal

what is the calculation for just the LE movement?

conjugate+vergence/2

What is the calculation just for RE movement?

conjugate-vergence/2

The 2 eyes move mostly -_________ during a blink

conjugately

What type of response is it when both pupils constrict even when stim is only in one eye?

consensual response

What are the 4 compnents of visual function?

drifts microsaccades tremor slow osicllations

why does the gain need to be greater than 1 when eyes fixate on a near target with VOR?

due to geometry considerations adn the fact that the eyes are NOT the center of rotation

what is a condition in which there is reading difficulty without a obvious visual or oculomotor defect?

dyslexia

strabismics will also sometimes show _____________ ___________, even though the fovea may be intact

eccentric fixation anomalous retinal correspondence

what is the ganglion and nucleus what the innvervates the ciliary muscle?

edinger-westphal nucleus ciliary ganglion

in clinic, is examining each system in isolation effective or ineffective?

effective!

Q Identify the true statement of the superior colliculus and fixation -its located caudally -encodes microsaccades -encodes drifts -encodes tremor all of above

encodes microsaccades it is rostral no evidence for drifts and tremor

oculomotor apraxia is sometimes accommpanied by ___________________, but specifically in relation to initiating saccades

excressive blinking

where is there an issue/ what is the syndrome with lid lag?

extrapyramidal syndromes

movements beyond the 35-40 deg range are usually achieved with a combo of what?

eye movement and head movement

what responses are added to get gaze?

eye+ head

what is another term for gaze?

eye-head saccades

what happens when someone is under anesthesia and sleep?

eyes drift outward (not in tonic state)

what things are affected with insufficient closure?

facial nerve nucleus basal ganglia-parkinsons frontal lobe lesions

there have been reports of rapid ___________ of targets during monocular fixation with amblyopic eye

fading

T/F tremor is large enough to make a visual effect

false small doesnt cause visual effect

does near or far VOR have greater gain ?

far

what does an uncrossed disparity give rise to the perception of? and what is this the stimulus for?

far stim to diverge

what is the amalgamated (combined) framework for binocular control?

fast and slow vergence systems

Which of the following experiments yielded convincing evidence that the SOA encodes a vergence signal? a. experimental lesion near OMN produced a deficit in vergence but not conjugate eye movements b. firing rates of neurons in the SOA showed modulation of activity during a vergence eye movement but did not show any modulation during conjugate eye movements c. anatomical studies showing that the SOA is connected to the fastigial nucleus d. in INO patients show a deficit in conjugate control but not vergence

firing rates of neurons in the SOA showed modulation of activity during a vergence eye movement but did not show any modulation during conjugate eye movements ** a is too difficult to do c and d are true statements but doesnt answer questiosn

Eyes move constantly despite attempt to?

fixate on a stationary object

when does our visual experience happen? what kind of eye movements?

fixation eye movements

what was demonstrated when going from the black dot to the white dot?

fixational eye movements (from the shift)

what is the normal reading eye movement that has periods of eyes being relatively still ?

fixations

What is Troxler Fading?

focus on black dot in center and the ring around dissapears

what were we doing when fixating on the black dot?

forming an after image

which part is affected if someone cant wink?

frontal lobe lesion think taking away personality

Does a partial or full blink have a higher peak velocity?

full

what is better, fusional vergence or accomm convergence?

fusional vergence

what is the form of vergence does retinal disparity drive ?

fusional vergence or disparity vergence

what does the 'straight' part of the staircase represent?

going to a new line while reading

what is the aca ratio that is measured by inducing accommodation with lenses and measuring the change in convergence?

gradient aca

do blinks increase or decrease with adult levels?

gradually increase from infancy

when the eyes are fixated on a near target, the VOR gain must be greater or less than 1 during head rotation?

greater

how large are the movements of tremor in arc min?

half arc min

what is special about an anableps? (south american trout)

has bifocals with 2 pupils that allows it to have clear vision above and below water

What is the stimulus for VOR?

head movements

which happens first in the head eye saccade, the head or eye ?

head starts later and the eyes move first

Who proposed the relaxation theory of accommodation?

helmholtz

What framework does pre-motor drive support and why?

helmholtz because it is monocular

What framework is more useful clinically?

hering

Internuclear ophthalmoplegia is a support for whos hypothesis?

herings

what is lid retraction in the opp eye to the ptosis an example of?

herings law

what does high spacial freq and low spacial freq cue?

high spacial is close low spacial is far

what can a unilateral defect in the optic nerve in front of the optic chiasm or severe retinal disease cause?

relative afferent pupillar defect RAPD

position errors (within fovea) must be kept to a _____________ to optimize VA for stationary objects

minimum

What kind of viewing conditions is 'blur driven accommodation' studied in?

monocular

what kind of circuits does the fast vergence use mostly?

monocular circuits supports helmholtz

what stim uses monocular and which uses binocular?

monocular- blur vergence binocular is disparity vergence

what kind of connections to the medial recuts motorneurons are made from the SOA?

monosynaptic

What does a larger ellipse indicate?

more instability in the eye fixation (so it increases with disease conditions)_

what happens when you find a deficit in one system?

most likely another system is making up for it (ex using saccades if something is wrong with SP)

Restriction of _______________ can be a cause of reading difficulty

motility

Herings framework: separate conjugate and vergence components of eye movements are summed at the level of what?

motorneurons

What 2 muscles play a more minor role?

mullers and frontalis

what does a crossed disparity give rise to the perception of? and is the stim for?

near stim to converge

when the lens is becoming more spherical, what is that allowing for vision?

near focus

Is the blur and disparity pathways under negative or postive feedback?

negative

divergence is positive or negative?

negative

only ring like ciliary muscle is under what kind of control?

neural control

close association between vergence and accommodation are controlled at which level?

neural level

where is the problem at if someone has a unilateral ptosis?

neuromuscular junction or CN 3

do fixations correspond to individual words in the text?

no

if someone has an RAPD then do they have a response when a light is shown to affected eye?

no

is there an antagonist muscle that goes against the ciliiary muscle?

no

are spontaneous blinks responses to dry eye? why or why not

no because anesthicized eyes still maintain blinks at normal rates

do the graphs look messed up with people that have congenital nystagmus ?

no because they have adapted to the problem

does vergence and saccades get controlled by the SOA?

no only vergence

Does vergence angle or visual information modulate VOR gain?

no there is no evidence of that

is the SD of fixational eye positions due to contrast and luminance?

no they are independent

Which of the following is the result of neural adaptation within the vestibular system? VOR gain with CL sustained head movement Myopes with SL reversal of nystagmus

none of the above

what is the marginal reflex distance MRD

normally 3-4 mm

What is the meausurement of width of the palpebral fissure?

normally 9-11mm

Accuired or congenital _____________ may disrupt reading by reducing the effectiveness of fixations- although many pts adapt to this problem

nystagmus

Q Pick the true statement -peak velocity of eye blinks are significantly lower than that of similar amplitude saccades -peak velocity of eye blinks show a main-sequence relationship to blink amplitude that has the same form as a saccade main sequence -peak velocity of eye blinks is lineraly related to blink amplitude -two eyes are disconjugate during a blink -none of the above

peak velocity of eye blinks is linearly related to blink amplitude

what type of adaptation is of the tonic vergence component?

phoria adaptation

vergence adaptation is made up of what 2 types of adaptation?

phoria and disconjugate adaptation

what is an example of a time when more than one eye movement is being stimulated?

playing tennis running on the treadmill and watching a show

what is the stimulus for saccades?

positional retinal error

Convergence is positive or negative?

positive

which (anterior or posterior) curvature decreases less?

posterior surface

Typically pts with central scotoma will pick a particular spot outside the fovea to fixate with and this is called ______________________________

preffered retinal locus (PRL )

What do fixation movements do?

prevent fading

eyes tend to rotate to ______position during a blink

primary viewing position

what is the measure of deviation of 1cm at a distance of 1m? what is the equivalence in degrees?

prism diopters equiv to 0.57 deg

what is the problem with colliers sign?

problem with vertical gaze centers rimlf or cajal

are the saccade system and control of vergence reponses processed separate or together?

processed together

what is another name for proximal vergence?

psychic vergence or voluntary convergence

what are the 2 under insufficient opening of the lids?

ptosis and pseudotosis

what happens to the choroid during accommodation?

pulled forward

what happens when the ciliary muscle contracts?

pulls toward the axis of the eye

What is the most prominent symptom of horners syndrome?

pupil constricting normally under bright light or near viewing, but wont dilate slowly to dim light or emotional stimulus

An observer looks at a static scene and ___________ separate the periods of fixation in which visual information is accquired

rapid eye movements (saccades)

what does this regression depend on?

reading difficulty

in a patient with a stable PRL, saccades become ______________________, so that the saccades made to a peripheral target will cause the target to land directly on the PRL

recalibrated

why does this troxler thing happen?

receptive field away from the fovea is larger - must shift focus always to see ring and dot

What happens to the lens diameter during accommodation?

reduced slightly

what 2 types of abberations are reduced when the pupil constricts in order to produce sharper retinal images?

reduced spherical and chromatic abberations

What happens to light on the retina when someone blinks?

reduces light level

What reduces and increases during presbyopia?

reduces range reduces gain increase in latency

What kind of blinks are made in response to a specific stimulus such as a flash of light, sudden loud noise, corneal irritation, looming objects

reflex blinks

where is the supranuclear control of the levator found?

regions in the cortex show lid elevation when stimulated

what is the reading eye movement that has small saccades which go in reverse direction (right to left)

regression

what does reading in a patient with amblyopia have more of? what increases in duration?

regressions and increased fixation duration

what is normally a larger value, the response or stimulus aca?

response

What does it mean to have a disorder of fixation control ?

there is too much control

why are all diff eye movements unique?

they have different specific stimuli

what do the stair graphs look like in patients with visual spatial dyslexia compared to the normal reader?

they have large regressions inaccurate return sweep saccades reverse staircase patterns

what does prism cause in adaptation of the R and L eye?

they move different amounts with prism on

is this the same mechanism of suppression like saccades?

thinking yes but dont know that for sure

how does the retinal slip with high frequencies matter when talking about cancellation of movements?

this is why the reduction of head motion sensitivity comes into play

what is the point of the fixational eye movements?

to gain more information about the target

prolonged viewing of a near stimulus changes what kind of vergence? 'default'

tonic

is smooth pursuit movements in the periphery tough or easy?

tough- person will move head instead

T/F accomm-vergence has different dynamics than fusional-vergence

true

T/F blinks can help break fixation

true

T/F it is an adapted state of looking at near target

true

T/F studies of saccade-vergence interaction have led to proposal of new monocular framework for control of eye movements

true

T/F the 2 eyes must rotate through different amounts

true

T/F there is a summation going on in the medial rectus motor neurons

true

where is disparity encoding happening in the cortex?

v1 MT/MST- temporal LIP -lateral inferior parietal

_____________ ___________ is a property of both systems

velocity storage

what is slower, vergence or saccades?

vergence

What kind of eye movements does the SOA respond to?

vergence ONLY not saccades (slide with the firing and showing both kinds of movements)

what are the cerebellar flocculus neurons in charge of?

vergence but mainly changing VOR gain with vergence angle

what happens along with the accommodation and vergence systems?

vergence eye movements

what could ocular misalignment be directly a problem of ?

vergence mechanisms

What is the vergence object stimulus and defocus stimulus?

vergence object stim is disparity defocus stim is for blur vergence


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