When you get blood drawn by a phlebotomist many of the collection tubes have heparin in them which increases the activity of antithrombin III. This chemical inactivates thrombin. Final Essay Question
What is the enzymatic function of thrombin?
To convert fibrinogen into fibrin.
What is the role of thrombin in the clotting cascade?
To convert fibrinogen into fibrin.
What is the purpose of accurate testing and analysis of blood components?
To diagnose and monitor various medical conditions.
What is the purpose of converting fibrinogen into fibrin?
To form the basis of a blood clot.
What is the role of antithrombin III in the regulation of clotting?
To inhibit the enzymatic function of thrombin.
What is the purpose of using heparin in blood collection tubes?
To prevent blood clotting and promote liquid sample collection.
What is the function of antithrombin III?
To regulate the activity of thrombin.
What is the clotting cascade?
A series of reactions leading to blood clot formation.
What is heparin?
An anticoagulant added to blood collection tubes.
How is the choice of anticoagulant determined?
Based on the specific testing requirements.
What components can be tested in a liquid blood sample?
Blood cell counts, chemistry profiles, or coagulation studies.
How does heparin enhance the inhibitory activity of antithrombin III?
By binding to antithrombin III.
How does heparin prevent the formation of a blood clot?
By inactivating thrombin.
How does heparin prevent blood clotting?
By increasing the activity of antithrombin III.
How does heparin enhance the inhibitory effect of antithrombin III?
By significantly increasing its inhibitory activity against thrombin.
What are some other anticoagulants used in blood collection tubes?
EDTA or citrate.
Are all tests in blood collection tubes required to be anticoagulated?
No, only certain types of tests require anticoagulation.
What types of tests require a liquid blood sample?
Tests that require accurate testing and analysis of various components.
