ALAT chapter 2
True of false: the PHS policy covers all live vertebrates used or intended for use in research, training, experimental purposes, and biological testing.
True
PHS Policy
Federal mandate that covers all live vertebrates used or intended for use in research, research training, experimentation, biological testing, or for related purposes
Animal use protocol
A document written by the Principal Investigator and approved by the IACUC, that describes and justifies the use of animals for a project
association for the assessment and accreditation of laboratory animal care international
A nonprofit organization that accredits laboratory animal research programs
Which organization accredits laboratory animal facilities that demonstrate that they are meeting the standards outlined in the guide and all federal and local regulations?
AAALAC
Which organization accredits laboratory animal facilities that demonstrate that they are meeting the standby outlines in the guide and all federal and local regulations?
AAALAC international
What is the name of the voluntary accreditation organization that inspects and accredits animal care programs?
AAALAC, international
Which organization published the 2000 panel on euthanasia, which is considered the standard to which all methods or euthanasia proposed in animal research protocols are judged?
AVMA
What types of euthanasia methods are listed in the AVMA guidelines for euthanasia of animals?
Acceptable, conditionally acceptable, and unacceptable methods
Institutional Animal Care and Use Committee (IACUC)
An institutional body that oversees and evaluates an animal care program
Quality assurance unit
An institutional unit that ensures compliance with the GLPs
What federal agency is responsible for enforcing and administering the Animal Welfare Regulations?
Animal and plant health inspection service
Why federal agency is responsible for enforcing and administering the animal welfare regulations?
Animal and plant health inspection service
Which document on animal research is reviewed and approved by the Institutional Animal Care and Use committee?
Animal use protocol
What is stated as a requirement for compliance with the US principles for the utilization and c are of vertebrate animals used in testing research and training?
Animals that suffer unrelieved pain and distress should be painlessly killed at the end of the procedure Transportation, use and care of animals should be in accordance with the Animal Welfare Act Procedures that cause more than momentary or slight pain must be performed with appropriate sedation, analgesia, and anesthesia
What is NOT a requirement of the AWA/AWR a researcher must comply with, if they house covered species? A. Provide dogs with exercise B. Appoint an unaffiliated member to the IACUC C. Meet or exceed sanitization standards for both cages and facility D. Submit an annual report including the number of covered species used
B. Appoint an unaffiliated member to the IACUC
prevents pathogens from exiting the room to protecting people and animals elsewhere in the facility.
Biocontainment
Why is the term for the field of study concerned with the philosophical issues rises by some medical procedures and treatments?
Bioethics
prevents microrganism access into the room to protect the animals.
Bioexclusion
What is NOT a component of an animal care and use program described in the guide? A. Euthanasia B. Personnel qualifications C. Genotyping procedures D. Animal environment and housing
C. Genotyping procedures
Which of the following species is covered by the animal welfare act? A. Zebra fish B. Mice C. Hamsters D. Birds bred specifically for research
C. Hamsters
List two alternatives to using animals models for research
Cell culture Mathematical models
According to the animal welfare act, list the three types of members who must sit on the institutional animal care and use
Chair Vet Non-affiliated member
Beyond food, water, shelter, and healthcare requirements, to comply with the AWA, what must be provided to dogs in a laboratory animal research facility?
Exercise
What is NOT a component of an animal care and use program described in the guide? A. Genotyping procedures B. Euthanasia C. Personal qualifications D. Animal environment and housing
Genotyping procedures
Which animals used in laboratory animal research would be covered by the animal welfare act
Guinea pigs rabbits hamsters ferrets wild mice horses gerbils goats sheep
What is the name of the committee made up of scientists and nonscientists that reviews animal use protocols, inspects they animal facility, and monitors experimental procedures in which animals are used?
IACUC
Which organization represents the interests of the public and the scientific community in areas of legislation and regulations on the use of laboratory animals?
NABR
Which agency is responsible for enforcing the Public Health Service Policy on Humane Care and Use of Laboratory Animals (PHS Policy)?
Office of laboratory animal welfare
Which agency is responsible for enforcing the Public Health Service policy involves humane care and use of laboratory animals (PHS Policy)?
Office of laboratory animal welfare
List difference between PHS policy and the animal welfare act
Page 12-13
List five components of an animal care and use program for which the guide describes the standard
Personal qualifications and training Occupational health and safety Veterinary care Animal environment Animal procurement and transportation Surgical and postsurgical care Alleviation of pain and distress Euthanasia Physical plant design and construction
Guide for the Care and Use of Laboratory Animals
Primary source of the standards and guidelines for laboratory animal care and use in the United States
Identify the members of the research team
Principal investigator Laboratory animal technicians Laboratory animal veterinarians Commercial animals supplier
Beyond food, water, shelter, and healthcare requirements, to comply with the AWA, what must be provided to monkeys in a laboratory animal research facility?
Psychological enrichment
The appropriate use of analgesics in postsurgical animals would apply to which of the 3Rs principles ?
Refinement
Using 100 miles in a research study instead of 150 would be an example of which of the 3Rs?
Reduction
What are the requirements in the animals welfare act and the animals welfare regulations if covered species are used
Register with USDA Appoint an IACUC Provide training for all animal users Maintain animals records Provide adequate housing Meet sanitization Etc.
Good Laboratory Practices
Regulations developed by the food and drug administration (FDA) and the environment protection agency (epa) to validate and document the processes of safety testing
What do the 3Rs stand for in regards to animal experimentation?
Replacement, refinement, reduction
Office of Laboratory Animal Welfare (OLAW)
The body that administers and enforces the PHS policy
Animal and plant health inspection service
The body the administers and enforces the animal welfare regulations
What document is used by AAALAC, international as the "gold standard" to evaluate an accredited laboratory animal care and use program?
The guide for the care and use of laboratory animals
According to the animal welfare regulations, to which official does the IACUC report?
The institute official (IO) or the Chief Executive Officer (CEO)
According to the animal welfare regulations, to which official does the IACUC report?
The institutional official (IO) or chief executive officer (CEO)
Some institutions may have to comply with the PHS policy but not with the animal welfare act and regulations and vice versa. Other institutions must comply with both. List two factors that help determine which regulations are relevant to a particular research study
The species of animal used The funding sources
What government agency is in charge of preparing standards and enforcing the Animal Welfare Act?
USDA
Identify the 4 members that should make up the Institutional Animal Carr and Use committee.
Veterinarian with lab animal medicine experience Scientist with animal use experience Nonscientist Outside member not affiliated with the institution
Standard Operating Procedures (SOPs)
Written instructions approved by management and used to perform a routine activity
Using the minimum number of animals that will serve a useful purpose, yet yeild statistically sound data and produce scientific benefit demonstrates which principle?
reduction
Why national nonprofit organization offers certification for Laboratory Animal Technicians?
AALAS
If an incident of animal misuse is not resolved after contacting your supervisor, you can submit your concerns to whom?
IACUC chair
Who does an ALAT report suspected animal misuse or mistreatment?
IACUC chair OLAW Clinical vet Director of animal resources Animal care supervisor
