Cellular Respiration - Poisons
Why would a person on DNP feel hot. Any chemical reaction generates heat as by-product.
As the process of cellular respiration proceeds, heat is generated and realized. Since every cell in the body uses the ATP generated through the cellular respiration for their daily functions, a small amount of heat is released.
Where in the metabolic pathway would you expect to find pyruvate dehydrogenase?
At the modification of pyruvate
Why does the type of bond that cyanide forms with the complex matter?
Covalent bonds are strong bonds. It requires a lot of energy in order to break the bond.
Which two stages of cellular respiration does the drug DNP interrupt?
ETC and the ATPase
Which stage of cellular respiration is inhibited from Cyanide?
Electron Transport Chain
What is the method of transport that allows arsenic to enter the cell?
Facilitated diffusion
Why does the individual lose weight from the DNP drug?
Glycogen (glucose are rapidly used up) and the cell rest to alternative fuels such as proteins and fats.
A chemist has discovered a drug that blocks phosphoglucoisomerase, an enzyme that catalyzes the second reaction in glycolysis. He wants to use the drug to treat people with bacterial infections. However, he can't do this because______.
Human cells also preform glycolysis; the drug might also poison them.
What is another name for a proton?
Hydrogen ions
A drug tested in the lab is found to create hols in both membranes of the mitochondria. Scientist suspect that the drug will be harmful to humans because it will____?
Interfere with Kreb's cycle, ETC, and ATP synthase.
Can the cell continue to produce ATP?
Yes, only temporarily through the use of glycolysis. Glycolysis will eventually continue into fermentation since oxygen is inhibited from ETC. The amount of ATP generated is not enough to sustain the cell.
Does the citric acid cycle produce any usable form of energy?
Yes, it generates a small amount of ATP and the generation of NADH and FADH2 carry electrons as potential energy until they are releases to ETC.
Where are the carbohydrates and fats stored in the body?
Muscle cells and liver cells
Why is the inhabitation of oxygen at the electron transport chain stage so critical?
Oxygen is the final electron acceptor at the end of the electron transport chain. When it is inhibited, it cannot pick up electrons.
What effect does inhabitation of the enzyme have on the rest of the metabolic pathway?
Pyruvate is not converted into acetyl-CoA and therefor cannot proceed into the Kreb's cycle.
What happens to the cells in the areas arsenic effects?
The cells are unable to generate enough ATP to carry out their cellular functions, so the cell eventually dies.
What is the importance of a proton gradient in the mitochondria?
The proton gradient drives the ATP synthase motor in order to regenerate ATP from ADP and P+
How does a noncompetitive inhibitor work?
They bind to enzymes in a place other than the active site. This causes the protein to change shape, which affects the active site.
Rotenone is insecticide, but is not available for general use. It is toxic to wildlife and humans as well as insects. The poisons blocks the electron transport chain. When it does so, glycolysis and the citric acid cycle eventually stop. This is because_______.
they run out of NAD+ and FAD.
