exam 2 SAMPLE QUESTIONS FROM DR .YOUAN'S LECTURE

A) Encapsulated dissolution B) Ion-exchange C) Matrix diffusion D) Matrix dissolution E) Osmotic pumping 14-Drug is bound to a resin and released due to changes in pH 15-Drug is compressed into tablets with a slowly soluble polymer 16-Drug is compressed into tablets with an insoluble polymer 17-Drug is compressed into tablets with semipermeable membrane and a laser drilled hole through which drug is transported out by convective flow.

B) Ion-exchange D) Matrix dissolution C) Matrix diffusion E) Osmotic pumping

Which two ingredients serve as both glidants and anti-adherent agents? A. talc and magnesium stearate B. polyethylene glycol and titanium dioxide C. microcrystalline cellulose and Lactose monohydrate D. croscarmellose sodium and providone (PVP)

A. talc and magnesium stearate

The rectal route of administration of drug may be preferred over the oral route for some systemic-action because A) the drug does not have to be absorbed B) absorption is predictable and complete C) a portion of the absorbed drug does not pass through the liver before entering the systemic circulation D) inert binders, diluents, and excipients cannot interfere with absorption E) the dissolution process is avoided.

C) a portion of the absorbed drug does not pass through the liver before entering the systemic circulation

What is the active form of Nepafenac? A. Diclofenac B. Ibuprofen C. Amfenac D. NAC (acetylcysteine)

C. Amfenac

What is the role of propylene glycol in Imvexxy? A.) Plasticizer B.) Lubricant C.) Preservative D.) Suppository Base

C.) Preservative

5. Which one of the following statements concerning tablet dissolution is NOT true? A) Disintegration precedes dissolution B) In vivo disintegration is usually a good predictor of dissolution C) Changing a drug's crystalline state may change dissolution rates D) Increasing tablet compression force will increase dissolution E) Micronization of drug powder will decrease dissolution time

D) Increasing tablet compression force will increase dissolution

What is a reason why rectal suppository formulation of an NSAID would be preferred for a patient? A. Rectal suppositories offer less therapeutic response than other formulations B. Patient is unconscious C. Patient is alert, aware, and able to swallow pills or capsules D. Patient is experiencing nausea/vomiting E. Both B and D

E. Both B and D

What is a disadvantage with using direct compression method? A. Fewer steps B. Direct compression excipients possess inherent disintegration properties (microcrystalline cellulose) C. Faster dissolution compared to wet granulation E. Occurrence of unblending due to variability in API and excipients

E. Occurrence of unblending due to variability in API and excipients

Agents that might be used to coat enteric-coated tablets include: I. hydroxypropyl methylcellulose (HPMC) II. carboxymethylcellulose (CMC) III. cellulose acetate phtalate (CAP)

III. cellulose acetate phtalate (CAP)

Which of the following is true about the storage conditions of DSUVIA? a. DSUVIA should be stored at 30 degrees celsius b. DSUVIA should be stored away from light c. DSUVIA can be stored in a bathroom cabinet d. Because light only affects color, it does not matter if DSUVIA is protected from light

b. DSUVIA should be stored away from light

A) Excessive moisture in the granulation B) Entrapment of air C) Tablet friability D) Degraded drug E) Tablet hardness 10-Picking 11-Mottling 12-Capping 13-Sticking

A) Excessive moisture in the granulation D) Degraded drug B) Entrapment of air A) Excessive moisture in the granulation

9. The shells of soft gelatin capsules may be made elastic or plastic-like by the addition of A) sorbitol B) povidone C) polyethylene glycol (PEG) D) lactose E) hydroxypropyl methylcellulose (HPMC)

A) sorbitol

Under what temperature conditions should Indocin suppositories be stored? A. 2°C to 8°C (36°F to 46°F) B. 8°C to 14°C (46°F to 57°F) C. 0°C to 6°C (32°F to 42°F) D. Below 0°C (32°F)

A. 2°C to 8°C (36°F to 46°F)

7. Dose dumping is a problem in the formulation of A) compressed tablets B) modified-release drug products C) hard gelatin capsules D) soft gelatin capsules E) suppositories

B) modified-release drug products

6. Which of the following is NOT a function of the lubricant in a tablet formulation? 2 A) Improving flow properties of granules B) Reducing powder adhesion onto the dies and punches C) Improving tablet wetting in the stomach D) Reducing punch and die wear E) Facilitating tablet ejection from the die

C) Improving tablet wetting in the stomach

How is NuvaRing to be used? A) Worn around the wrist B) Only inserted into the vagina prior to intercourse C) Inserted into the vagina and left in for 21 days

C) Inserted into the vagina and left in for 21 days

4. The United States Pharmacopeia (USP) content uniformity test for tablets is used to ensure which of the following qualities? A) Bioequivalency B) Dissolution C) Potency D) Purity E) Toxicity

C) Potency

3. United States Pharmacopeia (USP) tests for ensuring the quality of drug products in tablet form include all of the following EXCEPT. A) disintegration B) dissolution C) hardness and friability D) content uniformity E) weight variation

C) hardness and friability

If the API of 125 mg tablet decays by zero-order kinetics with a reaction rate constant kinetic of 0.5 mg per hour, what is the amount of intact drug remaining after 3 days (72 hours)? A. 0.89 mg B. 8.9 mg C. 89 mg D. 890 mg

C. 89 mg

Which of the following is not a coating agent used for Rilutek? A. Hypromellose (HPMC) B. Polyethylene Glycol 6000 C. Hypromellose Phthalate (HPMCP) D. Titanium Dioxide

C. Hypromellose Phthalate (HPMCP)

Viral transduction enhancers are materials used to increase the amount of gene expression in the target tissue. Which of the following ingredients assists in gene transduction efficiency? A. Sodium phosphate dibasic B. Sodium chloride C. Poloxamer 188 D. Sodium phosphate monobasic

C. Poloxamer 188

A satisfactory suppository base must meet all of the following criteria EXCEPT A) it should have a narrow melting range B) it should be nonirritating and nonsensitizing C) it should dissolve or disintegrate rapidly in the body cavity D) it should melt below 30 degrees C E) it should be inert

D) it should melt below 30 degrees C

2. A sweetener that is widely employed in chewable tablet formulas is A) aspartame B) glucose C) lactose D) mannitol E) sucrose

D) mannitol

1. If a bottle of tablets has an expiration date of "Dec 2021", the pharmacist may continue to dispense the product A) up to 1 year after the expiration date B) only through January 31, 2021 C) only through December 15, 2021 D) only through December 31, 2021 E) if the pharmacist informs the patient to discard unused tablets in 6 months

D) only through December 31, 2021

What does Luxturna use as a vector to carry a functional gene into the affected eye tissue? A. Poxvirus B. Adenovirus C. Retrovirus D. Adeno-associated virus

D. Adeno-associated virus

Which of the following capsules sizes has the largest capacity? A) 5 B) 4 C) 1 D) 0 E) 000

E) 000

Most commercial vaginal suppositories use a base of A) Beewax B) Cocoa butter C) Glycerin D) glycerinated gelatin E) Polyethylene glycols

E) Polyethylene glycols

True statements, about the function of excipients used in tablet formulations include: I. binders promote granulation during the wet granulation process. II. glidants help to promote the flow of the tablet granulation during manufacture. III. lubricants help the patient to swallow the tablets.

I. binders promote granulation during the wet granulation process. II. glidants help to promote the flow of the tablet granulation during manufacture.

Advantages to the manufacturer for tablet film coating when compared to sugar coating include: I. shorter production times II. less gross weight III. lower incidence in coat chipping

I. shorter production times II. less gross weight III. lower incidence in coat chipping

The prime purpose for which of the following types of coating may be to mask the bitter taste of an orally administered drug? I. Enteric II. Film III. Sugar

II. Film III. Sugar

Which of the following is the active ingredient of Methylin? a. Methylphenidate HCl b. Aspartame c. Microcrystalline Cellulose d. A and C e. All of the Above

a. Methylphenidate HCl

Which of the following statements is not true about Methylin (methylphenidate HCl)? a. It is a central nervous system stimulant. b. It stimulates the reuptake of norepinephrine and dopamine. c. It is used for the treatment of Attention Deficit and Hyperactivity Disorder (ADHD). d. Maltose and aspartame are two ingredients that act as sweeteners. e. It is classified as "class I" in regards to the Biopharmaceutics Classification System.

b. It stimulates the reuptake of norepinephrine and dopamine.

Which flavoring is used in the ODT tablet? a. Mint b. Orange c. Strawberry d. Ghost Pepper e. Attack Helicopter

c. Strawberry

As described in Case Study 1, Decadron is a conventional release tablet. Given that Decadron follows first-order releases kinetics, it can be assumed: a. The rate of drug release is independent of time and constant over time b. The rate of drug release is delayed for a predefined period of time c. The rate of drug release declines exponentially with time d. The rate of drug release increases exponentially with ti

c. The rate of drug release declines exponentially with time

In which solubility class can you find Norvir? a. Class I b. Class II c. Class III d. Class IV

d. Class IV

Starch is the main disintegrant ingredient in the Decadron tablet formulation. The primary purpose of starch is to: a. Promote particle aggregation/cohesion in liquid state b. Prevent sticking to die and punch c. Facilitate flow of granules from hopper d. Promote break down of particle aggregates

d. Promote break down of particle aggregates

Which of the following is not an available formulation for Norvir? a. Tablet b. Soft gelatin capsules c. Solution d. Suspension

d. Suspension

Which of the following is not an ingredient(s) in ibuprofen: a. Maltose b. Lactose c. Croscarmellose sodium d. Colloidal silicon dioxide e. Hot Butter f. A and E g. B and C h. None of the Above

f. A and E

Formulation of ibuprofen involves: a. Low shearing mixing b. Pre-formed ingredients c. Wet Mixtures d. Explosions e. A and B are correct f. None of the above

f. None of the above