Foundations 2 quiz 3 (gout)

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Kineret (anakinra) is an IL-1 inhibitor used in the treatment of inflammation associated with gout. which of the following best describes its mechanism of a IL-1 inhibition

Recombinant IL-1 receptor antagonist

Which of the following drugs used for the treatment of chronic gout achieve their effectiveness by increasing urate secretion

1, 2

Which of the following drugs are classified as uricosuric agents

1,2

Which of the following agents used to treat gout is a hypo xanthine isomer

3

Which of the following drugs used to treat gout are xanthine oxidase inhibitors

3

Which of the following agents used in the treatment of an acute gout attack work to reduce pain/inflammation

3 &5

Which of the following agents used to treat gout is a non-purine and Xanthine oxidase inhibitor that acts as a non-competitive inhibitor

4

Which of the following drugs used to treat gout are xanthine oxidase inhibitors

4

Which of the following agents used to treat gout is an NSAID

5

IIraris (canakinumab) is an IL-1 inhibitor used in the treatment of inflammation associated with gout. which of the following best describes its mechanism of IL-1 inhibition

Anti IL-1beta monoclonal antibody

The following drugs is metabolized by xanthine oxidase and therefore is contraindicated with febuxostat

Azathioprine

Which of the following agents used in the treatment of hyper uricemia /gout act by converting uric acid to a more water soluble metabolite, allantoin.

Hairy donut

Which of the following agent should not be used in individuals with a glucose six phosphate dehydrogenase deficiency

Krystexxa (pegloticase)

Which of the following drugs is an alkaloid used to treat acute gout flareups?

Number 5

Which of the following drugs have significant drug interactions with the uricosuric agent

Penicillin, salicylates, indomethacin naproxen, sulfonylureas

Which of the following is the ADR that limits the dosing of coldest (colchicine)

Severe diarrhea

Rasburicase and pegloticase Are uricase enzymes that metabolize uric acid to a more water soluble metabolite, allantoin. Select all the below statements that are true regarding these drugs

These are protein-based drugs that must be administered by IV infusion and peg elation of the protein results in an extended half-life of the drug

Which of the following transporters are inhibited by both probenecid & lesinurad

URAT1

Which of the following best describes the drug shown below

Uricosuric agent

Which of the following best describes the drug shown below

Xanthine oxidase inhibitor

Which of the following is a uricosuric agents that promotes uric acid excretion by inhibiting URAT 1 & OAT4

Zurampic (lesinurad)


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