Guinea Pig Module

What best describes the purpose of the federally mandated "alternatives search" in an animal protocol? An assurance by an information specialist that no alternative to the proposed animal model exists A narrative to justify the use of the animal model based on experimental data A search for non-animal methods to replace the proposed use of animals A search for procedures that may replace animals, reduce animals used, or refine methodology to minimize pain or distress

A search for procedures that may replace animals, reduce animals used, or refine methodology to minimize pain or distress

What is NOT a peripheral vessel accessible in sedated, but not anesthetized guinea pigs? Jugular vein lateral saphenous vein Medial saphenous vein Dorsal metatarsal vein

Jugular vein

Which statement is TRUE regarding venipuncture procedures in guinea pigs? Cardiac puncture is most often only permitted as a terminal procedure. Sedation reduces the volume of blood that can be collected from peripheral veins. The orbital venous sinus is a preferred location for blood collection. The guinea pig lacks accessible peripheral veins in the hind limb.

Cardiac puncture is most often only permitted as a terminal procedure.

According to the AVMA, which methods are ACCEPTABLE, when used alone, for euthanasia of guinea pigs? Check all that apply. Decapitation Dissociative agent combinations Overdose of barbiturate Inhalation of carbon dioxide

Dissociative agent combinations Overdose of barbiturate

The information that should be provided with the results of a database search for alternatives includes which of the following? Names of the databases used, date of the search, years of citations accessed, and search strategy The library service used to perform the search, the date of the search, and the key words used A narrative summarizing experimental data that justifies the use of the proposed animal model The Medline list of citations, the date of the search, and the years of citations accessed Names of databases used, the date of the search, and the years of citations accessed

Names of the databases used, date of the search, years of citations accessed, and search strategy

Which regulatory document requires an institution to have an occupational health and safety program for all personnel working with animals? Public Health Service Policy The Animal Welfare Assurance The Guide Animal Welfare Act

Public Health Service Policy

Who must approve all animal use protocols? The Institutional Review Board The Institutional Animal Care and Use Committee The Institutional Official The Attending Veterinarian

The Institutional Animal Care and Use Committee

Which is true regarding guinea pigs that have newly arrived at a facility? Animals must have an acclimation period following the quarantine period. The animals should be housed in a quarantine area and may undergo diagnostic testing. Animal health status can be determined from the documentation accompanying the animal shipment. Experimentation on the animals is generally delayed until the end of quarantine.

The animals should be housed in a quarantine area and may undergo diagnostic testing. Experimentation on the animals is generally delayed until the end of quarantine.

Fasting of guinea pigs before endotracheal intubation is necessary because: The endotracheal tube may stimulate vomiting. The endotracheal tube may carry food from the oropharynx into the trachea. Guinea pigs may vomit during anesthesia. All of the Above

The endotracheal tube may carry food from the oropharynx into the trachea.

What concept is relevant to the proper conduct of euthanasia? Experimental criteria are the primary determinant of the euthanasia method that is acceptable for an animal. Staff competence to handle and restrain the species of animal is the training objective for performing euthanasia. The selection of an appropriate euthanasia method need not address esthetic considerations for staff and onlookers. The selection of an appropriate euthanasia method should address considerations of humaneness to the animal, and safety and esthetics for the staff.

The selection of an appropriate euthanasia method should address considerations of humaneness to the animal, and safety and esthetics for the staff.

Which occupational health and safety concerns are NOT relevant to working with guinea pigs? Lymphocytic choriomeningitis virus (LCM) infection Microsporum fungal infection Allergies Toxoplasmosis

Toxoplasmosis

Which statement is TRUE regarding the conduct of surgery in guinea pigs? Nonaseptic surgical practices are acceptable when it can be shown that guinea pigs do not develop postsurgical infections. Nonaseptic technique for survival surgery in guinea pigs is permitted by the Guide for the Care and Use of Laboratory Animals. Applicable federal mandates require aseptic technique for the conduct of nonsurvival surgery in guinea pigs. Applicable federal mandates require the use of aseptic technique for survival surgery in guinea pigs.

Applicable federal mandates require the use of aseptic technique for survival surgery in guinea pigs.

Which statement is TRUE regarding care procedures for guinea pigs undergoing surgery? Supportive care and monitoring can be discontinued when the guinea pigs have recovered from anesthesia. Antibiotics should be routinely administered to avoid wound infection. Assessment of wound repair is the only objective of post-operative monitoring. During the procedure, guinea pigs should be monitored for anesthesia, body temperature, and cardiovascular and respiratory function.

During the procedure, guinea pigs should be monitored for anesthesia, body temperature, and cardiovascular and respiratory function.

Which statement regarding guinea pig reproduction is FALSE? Guinea pig young are born blind, naked and helpless. If a sow's pubic bones have fused, cesarean section may be required to birth the young. Guinea pig pups are easily fostered onto another mother if required. Female guinea pigs who are mated after 6 months of age are more likely to have difficult births.

Guinea pig young are born blind, naked and helpless.

Which statement is true regarding antibiotic administration to guinea pigs? Gram positive antibiotics are preferred for use in guinea pigs. Antibiotics should be administered routinely following surgery in guinea pigs. Guinea pigs commonly develop a toxic shock syndrome when administered antibiotics. At most, the only adverse effect of antibiotics in guinea pigs is a mild diarrhea that is well tolerated by the animals.

Guinea pigs commonly develop a toxic shock syndrome when administered antibiotics.

Which statement(s) is(are) true regarding the assessment of pain or distress in guinea pigs? Guinea pigs with a mild to moderately painful condition may appear and behave normally. The principal sign of pain in guinea pigs is aggression to handling. Pain in guinea pigs is commonly expressed by subtle changes in activity level and behavior. Guinea pigs displaying normal behavior can be assumed to be free of pain and distress.

Guinea pigs with a mild to moderately painful condition may appear and behave normally. Pain in guinea pigs is commonly expressed by subtle changes in activity level and behavior.

Which immune cell type is unique to guinea pigs? Natural killer cells Karamazov cells Macrophages Kurloff cells

Kurloff cells

Which statement regarding malocclusion in guinea pigs is FALSE? Guinea pig teeth are open rooted and grow continuously if not worn down by gnawing. Affected animals may have wet fur around their mouths due to excess salivation. Malocclusion will only affect the incisors. Malocclusion can be caused by congenital abnormalities or dietary deficiencies.

Malocclusion will only affect the incisors.

Which statement is TRUE regarding anesthesia in guinea pigs? Dose rates (ml/kg) of injectable agents are the same for the common laboratory animal species. Long term anesthesia is appropriately achieved by gas anesthesia using a vaporizer. Ether is a preferred agent for gaseous anesthesia. Long term anesthesia is appropriately achieved by repeat dosages of a short-acting injectable anesthetic cocktail.

Long term anesthesia is appropriately achieved by gas anesthesia using a vaporizer.

Guinea pigs require thermal support during anesthesia because: they have a low metabolic rate. it is required by USDA regulations they lose body heat rapidly under anesthesia. None of the Above

they lose body heat rapidly under anesthesia.