Human Growth Hormone (hGH)

Actions in first stage of hGH

1) increased AA uptake 2) stimulation of glucose uptake 3) blocks lipid breakdown 4) preps body for growth & activity

Action of second stage of hGH

1) increased mobilization of FFA 2) inhibition of glucose uptake

Why did hGH gain popularity?

1980s - due to the dislike towards anabolic steroids

How long do the effects of the first stage of hGH last?

4 hours

How was hGH obtained prior to 1985?

From the pituitary of cadavers

In humans, does hGH increase muscle mass & athletic performance?

NO

Who receives genetically engineered hGH?

ONLY patients who are hGH deficient

T/F: everyone already has enough circulating hGH

TRUE

T/F: nearly every organ depends on hGH

TRUE

Adverse effects of hGH on adults leads to...

acromegaly

Second stage effects

chronic use effects (weeks to months)

Why did genetically engineered hGH become available?

contraction of disease resulted in liver damage by 4 boys

Adverse effects of hGH on children leads to...

gigantism

Genetically engineered hGH mimics...

hGH released by the pituitary

Adverse effects of hGH

increased internal organ growth predisposes one to chronic diseases

What causes the increase in lean body mass?

increased size of internal organs & water retention

In humans, hGH ___ lean body mass

increases

hGH administration

injection

First stage of hGH causes what types of effects?

insulin-like effects

Problem w/ people using hGH

people use 10-20x recommended therapeutic dosage

hGH works through stimulation of various growth factors that...

stimulate cellular processes (DNA/RNA)

Today's hGH distribution is ___ regulated

tightly