Lecture 10/10

Which of the following reactions is most likely to give a poly substituted product? A) friedel-crafts alkylation B) friedel-crafts acylation C) nitration D) sulfonation E) halogenation

A

Which of the following compounds would be least reactive toward electrophillic aromatic substitution? A) I B) II C) III D) IV E) V

A) I

Which of the following compounds will be least reactive towards a Friedel-Crafts reaction? A) nitrobenzene B) anisole C) phenol D) benzene E) chlorobenzene

A) nitrobenzene

Which of the following compounds will yield the ortho substituted compound as the major product for a nitration reaction? A) toluene B) ethylbenzene C) cumene D) t-butylbenzene E) none of these

A) toluene

Which of the following substituents will not direct the incoming group to the ortho/para position during electrophillic aromatic substitution? A) -CH2CH3 B) -CF3 C) -OCH3 D) -NHCH3 E) -Br

B) -CF3

Provide the reagents that are necessary to carry out the following conversion. t-butylbenzene ——> 1-t-butyl-4-chlorobenzene A) Cl2, heat B) Cl2, FeCl3 C) SOCl2, pyridine D) HCl E) PCl3

B) Cl2/FeCl3

Which of the following compounds will be most reactive towards an electrophillic aromatic bromination reaction? A) nitrobenzene B) anisole C) acetanillide D) benzene E) benzaldehyde

B) anisole

Which of the following cannot be used for a friedel-crafts alkylation reaction? A) bromobenzene B) vinyl chloride C) 2-chloropropane D) chloroethane E) both A and B

B) vinyl chloride

Which of the following substituents will direct the incoming group to the ortho/para position during electrophillic aromatic substitution? A) -NO2 B) -CF3 C) -Br D) -COOCH3 E) none of these

C) -Br

***Which of the following substituents will not direct the incoming group to the meta position during electrophillic aromatic substitution? A) -NO2 B) -C=N C) -OCH3 D) -COOH E) all of these

C) -OCH3

Predict the major product for the following reaction A) I B) II C) III D) IV E) V

C) III

Which of the following compounds does not undergo a Freidel-Crafts reaction? A) benzene B) chlorobenzene C) nitrobenzene D) toluene E) t-butylbenzene

C) nitrobenzene

Predict the major product for the following reaction A) I B) II C) III D) IV E) I & IV

D) IV

Which one of the following substituents will direct the incoming group to the meta position during electrophillic aromatic substitution? A) -NO2 B) -C=N C) -CCl3 D) -COOH E) all of these

E) all of these

Which of the following substituents will direct the incoming group to the ortho/para position during electrophillic aromatic substitution? A) -CH2CH3 B) -CF3 C) -OCH3 D) -COOCH3 E) both A and C

E) both A and C