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51. What is the most common Arenavirus?

Lossa

14. What bacteria is associated with safety pin like appearance when stained?

yesinia pestis

30. What bacteria is known to grow at 28*C?

yesinia pestis

32. Which of the following is not a virulence factor of Listeria?

ADR

7. T/F - there is a vaccine for yellow fever

T

36. What disease is associated with occupational infection?

erysipeloid

19. Which of the following does not kill a prion?

ethanol

49. True or False- Yesinia Pestis is not an intracellular parasite

false

46. What family of virus causes Colorado Tick Fever?

reovirus

41. What category B weapon causes Typhoid?

ricketsia prowaekii

17. What is the vector for the Hantavirus?

rodent

A cyanotic, listless, infant with extremely poor muscle tone is brought to the Emergency Room. Which condition is most likely?

Botulism

22. What is the altered for of the prion protien that makes it virulent?

PRPres + PRPsc

43. What is the reservoir for WNV?

bird

6. A patient presents with hemorrhage on the skin, enlarged liver and jaundice, the patiet recently went to Africa. What the dx?

yellow fever

1. 12 year old boy comes to the pediatrician presenting with brassy cough, coryza, and conjunctivitis, fever, malaise, and photophobia. History of present illness reveals that a few days ago his mother found minute, whitish spots over the buccal / labial mucosa that rapidly increased in number and coalesced. Red, morbilliform, blanching rash. Labratory: Unsegmented ssRNA with a helical nucleocapsid on viral isolation in the tissue culture. 2. Which of the following could be a fatal long term consequence of the above organisms?

1. Rubella (THIS QUESTION WAS DIFFERENT ON TEST WITH SAME ANSWERS... THE ANSWER FOR MY TEST QUESTION WAS MEASLES NOTE: Unsegmented ssRNA with a nucleocapsid is most commonly Rubella (Rubi Virus) in younger populations) 2. PRP (Progressive rubella panencephalitis (PRP) is a neurological disorder which may occur in a child with congenital rubella. It is a slow viral infection of the brain characterized by chronic encephalitis, usually manifesting between 8-19 years of age. It is believed to be due to persistence or reactivation of rubella virus infection.)

37. Overt bioterroism has a. Early recognition and health care workers as responders b. Later recognition and health care workers as responders c. Early recognition and typical first responders d. Late recognition and typical first responders

?

35. What bioweapon has the highest mortality rate?

A

A young man who had traveled extensively in Britain developed neurological disease and at autopsy Bovine spongiform encephalopathy (also known as 'Mad cow disease' and 'New-variant Creutzfeldt-Jakob disease') was confirmed. If the infectious agent were isolated from the patient's brain tissue, which phrase below would best describe it?

A single protein, encoded by a human gene

Being bitten by a tsetse fly (genus Glossina) would transmit which of the following disease:

African sleeping sickness

A 64 year old man has a history of chronic neurological symptoms over the preceding eight months, memory, cognition, and motor control are all affected. If this is Creutzfeldt-Jacob disease, what would you expect to observe in a brain biopsy?

Aggregates of bovine protein

A 55 year old woman developed diplopia, one day after eating home canned fruit. (Diplopia = double vision, from inability to coordinate the direction of gaze of the eyes.) A few hours later she develops difficulty speaking, bilateral weakness of her arms, nausea, vomiting, dizziness, blurred vision, and dry mouth. However she is alert, oriented, and has no fever. Choose the best diagnosis:

Botulism

Identify the definitive host for Toxoplasma gondii:

Domesticated cats

An 18 year old man has fever, stiff neck, headache, and difficulty speaking; he rapidly passes into a coma. CSF shows no signs of bacterial or fungal infections by contains many lymphocytes. A brain biopsy is ordered, principally to confirm or rule out Herpes simplex virus (HSV) as the cause of illness. Why is it important to distinguish HSV encephalitis from that caused by other viruses?

Drugs exist for treatment of HSV encephalitis

A child is immunized against Polio with the killed-virus (Salk) vaccine. This vaccine produces immunity to Polio by stimulating production of neutralizing antibody. What is the locating of the epitopes bound by these neutralizing antibodies?

Envelope glycoproteins

27. T/F there is an immune response with prion Dz

F

Prion diseases infect nervous tissue and cause vacuolations in the tissue by:

Forcing the conformational change of normal PrPc to Prp sc

26. What form of CDJ is associated with BSE - bovine spongiform encephalopathy)?

Iatrogenic/aquired

What is the etiologic agent of PML - Progressive Multifocal Leukoencephalopathy?

JC-Virus

23. Patient presents with Dementia, atxia muscle weakness and loss of motor control what is the best DX?

KURU

Which of the following organisms should you suspect in a case of fatal fulminant meningoencephalitis of a 7 year old boy from swimming in a pond?

N. Fowleri

53. Which of the following is not a typical agent? a. Prion b. Virus c. Bacteria

Prion

A 68 year old woman begins to suffer from motor and cognitive difficulties and, after seven months of progressive decline, dies. On the autopsy, in sections of brain tissue, there is prominent vacuolar degeneration of tissue and amyloid deposits, but no evidence of inflammation. Which of the following is most likely the cause of death?

Progressive multifocal leukoencephalopathy (JC Virus) (PML is caused by the JC virus, which travels to the brain, infects multiple sites, and destroys the cells that make myelin - the fatty protective covering for many of the body's nerve and braincells. Symptoms include various types of mental deterioration, vision loss, speech disturbances, ataxia (inability to coordinate movements), paralysis, brain lesions, and, ultimately, coma.)

Your patient is a young woman who wishes to become pregnant. Because of the risk to the fetus in a primary infection of a non-immune mother, for what parasitic protozoan should you check her immune status?

Toxoplasma gondii

A missionary returning from work in Central America is at risk of being bitten by an arthropod carrying which of the following protozoa?

Trypanosoma cruzi

4. A patient presents with fever, headache and severe rash and is having s/s of acute flaccid paralysis what you best dx and which viral family is it?

WNV-flavivirdae

A 72 year old woman, a resident of Atlantic County, NJ, develops signs and symptoms of viral encephalitis. Serology confirms the pathogen as Eastern equine encephalitis virus. Which line in the table below correctly identifies the environmental reservoir and vector of this virus?

Wild Birds- mosquito

A 38 year old man came to the office with a chief complaint of jaw discomfort and inability to open his mouth fully for 3 days. He also said he had struck his right shin with a hammer 10 days earlier while attempting to fix his lawn mower. The hammer penetrated deeply through the skin, and although the wound hurt and bled, he had not sought medical attention. Seven days after the original insult, he started noticing jaw discomfort and the inability to open his mouth completely. On the 3rd day of this discomfort, his wife urged him to seek medical attention. The patient had no history of medical or surgical procedures, he had no known allergies, and was not taking medications. The diagnosis of this disease can only be made on clinical grounds. What is the diagnosis?

Wound tetanus

31. Who is most likely to get Listeria? a. Geriatrics b. Pediatric c. All of the above

all of the above

1. What is the name of the virus that is transmitted through arthropods?

arbovirus

How would one acquire an infection with Trypanosoma cruzi?

being bitten by a kissing bug (genus Triatoma)

38. What would be considered an Overt attack?

bomb

10. What disease is common to be spread by drinking non-pasturized milk?

brucella

16. What form of the plaque was caused by a flea bite?

bubonic

47. What diseases listed below is not caused by a virus in the flavavirdae family?

california encephalitis

12. What animal would that has Brucella will cause spontaneous abortions come from?

cattle

25. What form of CJD has not person to person spread?

classical

2. What of the following is considered to be similar to Rocky mountain spotted fever?

colorado tick fever

45. What dx should have rocky mountain spotted fever in ddx?

colorado tick fever

40. What category B weapon causes Q-fever?

coxiella burnetti

3. Which of the following is also known as Break Bone Fever?

dengue

48. What disease can be confused with rubella or measles because of the similar rash?

dengue fever

5. What disease is associated with the immune enhancement hypothesis?

dengue fever

15. Which of the following family of viruses does not cause VHF? a. Arenavirdae b. Filovirdae c. Bunyavirdae d. Flavavirdae e. None of the above

e. none of the above

8. What is the most severe hemorrhagic fever?

ebola

52. What is the form of ebola was the cause of the last outbreak in the USA?

ebola reston

28. What disease is associated with acute febrile gastroenteritis?

listeria

33. Which of the following disease can be spread transplacentally?

listeria

34. Which of the following is not a Category A bioweapon?

listeria

29. Which bateria is know to grow at temperatures around 4*C?

listeria monocytogenes

44. What is the vector for WNV?

mosquito

39. Which attack is an announced attack?

overt

50. What disease is associated with a past descendent having this disease and now this person being immune to HIV?

plaque

18. What is the virus that causes PML -progessive multifocal Leukoencephalopathy?

polyoma virus

21. A patient autopsy shows neuron plaques (as seen in ALZ) and spongiform appearance to the brain and prior to death the patient has no musclular control what caused they dz?

prion

20. Scarpie is a Prion disease associated with which animal?

sheep

11. What is considered the most virulent organism that affects humans?

tuleremia

13. What is the most common form of Tuleremia?

ulceroglandular

9. What is the reservoir for Ebola?

unknown but possibly a bat

42. Which cycle is how humans get dengue fever?

urban

24. What form of CJD is most common in younger patients?

variant