ondansetron (zofran )
What serotonin receptor antagonist is prescribed to manage postoperative nausea and vomiting?
1. ondansetron
A pregnant patient who is taking ondansetron [Zofran] for morning sickness tells the nurse she is experiencing headache and dizziness. What will the nurse tell her? a.It is not safe to take this drug during pregnancy. b.These are common side effects of ondansetron. c.She should stop taking the ondansetron immediately. d.She should report these adverse effects to her provider
ANS: B.These are common side effects of ondansetron.The most common side effects of ondansetron are headache, diarrhea, and dizziness.Ondansetron is used off-label to treat morning sickness. These side effects do not indicatea need to stop taking the drug or to report the side effects to the provider.
The patient receiving chemotherapy rings the call bell and reports the onset of nausea. The nurse should prepare an as-needed dose of which medication? A. Morphine sulfate B. Zolpidem (Ambien) C. Ondansetron (Zofran)* D. Dexamethasone (Decadron)
C. Ondansetron (Zofran)* Rat.: Ondansetron is a 5-HT3 receptor antagonist antiemetic that is especially effective in reducing cancer chemotherapy-induced nausea and vomiting. Morphine sulfate may cause nausea and vomiting. Zolpidem does not relieve nausea and vomiting. Dexamethasone is usually used in combination with ondansetron for acute and chemotherapy-induced emesis.
Which drug works by blocking serotonin receptors in the GI tract, vomiting center, and CTZ? A. Meclizine (Antivert) B. Metoclopramide (Reglan) C. Ondansetron (Zofran) D. Droperidol (Inapsine) C.Ondansetron is a serotonin blocker. Metoclopramide is a prokinetic drug, meclizine is an antihistamine, and droperidol is an antidopaminergic drug.
C.Ondansetron is a serotonin blocker. Metoclopramide is a prokinetic drug, meclizine is an antihistamine, and droperidol is an antidopaminergic drug.
Which drug works by blocking serotonin in the gastrointestinal tract, vomiting center, and chemoreceptor trigger zone (CTZ)? A. metoclopramide (Reglan) B. meclizine (Antivert) C. droperidol (Inapsine) D. ondansetron (Zofran)
D. ondansetron (Zofran) R: Ondansetron is a serotonin blocker. Metoclopramide is a prokinetic drug, meclizine is an antihistamine, and droperidol is an antidopaminergic drug.
A nurse caring for a patient who is undergoing a third round of chemotherapy is preparing to administer ondansetron [Zofran] 30 minutes beforeinitiation of the chemotherapy. The patient tells the nurse that the ondansetron did not work as well the last time as it had the first time. What will the nurse do? a.Administer the ondansetron at the same time as the chemotherapy. b.Contact the provider to suggest using high-dose intravenous dolasetron [Anzemet]. c.Request an order to administer dexamethasone with the ondansetron. d.Suggest to the provider that loperamide [Lomotil] be given with the ondansetron.
Ondansetron is a serotonin receptor antagonist; drugs in this class are the most effectivedrugs available for suppressing nausea and vomiting associated with anticancer drugs. The drug is even more effective when combined with dexamethasone. For best effect,ondansetron should be given 30 minutes before beginning chemotherapy. Dolasetron issimilar to ondansetron, but when given intravenously in high doses, it is associated withfatal dysrhythmias. Loperamide is used to treat diarrhea
A client has been given Ondansetron (Zofran). For which condition should the nurse administer this medication to the postoperative patient? a. Vomiting b. Incisional pain c. Abdominal infection d .Atelectasis.
Vomiting Rationale: Ondansetron is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation). Options B, C, and D, are not related to this medication.
A client has nausea and is taking ondansetron (Zofran). The nurse explains that the action of this drug is what? a. Stimulate the CTZ b. Block serotonin receptors in the CTZ c. Block dopamine receptors in the CTZ d. Coat the wall of the GI tract and absorb bacteria
b. Block serotonin receptors in the CTZ
How does ondansetron achieve its therapeutic effect when prescribed for postoperative nausea?
blocking toxins by antagonizing serotonin receptors
A client, who is undergoing cancer treatment, is being discharged home with a prescription for ondansetron. When providing medication education concerning ondansetron, the nurse should describe the actions that the client can take to address what common adverse effect?
diarrhea
