Oxygen Hemoglobin Dissociation Curves

*Stored blood* loses ___________, causing a *Left shift* in the curve, while *hypoxia* stimulates the production of _______________ and thereby causing a *Right Shift*.

2,3-bisphosphoglycerate

What is the name of the *effect* that results from a *increased CO2 that results in a *decreased affinity* of hemoglobin for O2- *unloading of oxygen* at the *tissues*?

Bohr effect (shifts the O2 dissociation curve to the Right* Occurs in *peripheral tissues*. supplies more *O2* for the same given pressure.

What is the name of the *effect* that results from an *increased O2 that results in a *decreased affinity* of hemoglobin for CO2- *uploading of the O2* at the *lungs*?

Haldane effect. Now the decreased affinity of Hb for CO2 can bind O2 in the lungs to be carried to the tissues.

Explain whether the following promote: A. Shifts to the *Right* B. Shifts to the *Left* Steep part of curve, O2 content increased

L

Explain whether the following promote: A. Shifts to the *Right* B. Shifts to the *Left* Easier for tissues to extract oxygen

Right shift= less affinity

*Oxygen-Hb Dissociation Curves*: Statement on the backside.

The figure below represents 3 major points on the oxygen-hemoglobin disso- ciation curve. The numbered sites refer to the hemoglobin site numbers discussed just previously.

Between Factors that cause *right or left shifts* and factors that cause *anemia or polycythemia*. which one effects *P50*?

anemia and polycythemia will not change *P50*. Factors that cause left and right shifts increase and decrease the P50, such as increased *2-3 BPG*?

Explain whether the following promote: A. Shifts to the *Right* B. Shifts to the *Left* More difficult for tissues to extract oxygen

left shift= higher affinity

Explain whether the following promote: A. Shifts to the *Right* B. Shifts to the *Left* P50 decreased

left shift= higher affinity

Explain whether the following promote: A. Shifts to the *Right* B. Shifts to the *Left* Steep part of curve, O2 content decreased.

left shift= higher affinity

What points on the *O2-Hb* dissociation curve are truly affected by the *right or left shifts*?

only the points on the steep part of the curve are affected.

Explain whether the following promote: A. Shifts to the *Right* B. Shifts to the *Left* P50 increased

right shift= less affinity

Question on backside

what are the following factors that shift the curve to the *right*? what are the following factors that shift the curve to the *left*?