Skeletal Muscle Contraction (14 Steps)
Step 4
Acetycholine (ACh) binds to receptors on the sarcolemma
Step 3
Acetycholine (ACh) release
Step 1
Action potential arrives at the axon terminal
Step 6
Action potential travels down the sarcolemma to the T-tubule
Step 8
Calcium binds to troponin -removes tropomyosin from blocking myosin-binding sites -cannot occur without calcium
Step 7
Calcium release from the sarcoplasmic reticulum (SR)
Step 13
Cocking of the myosin head -due to ATP breaking down to ADP and P
Step 9
Contraction begins
Step 12
Cross bridge detachment -due to ATP binding to the myosin head
Step 10
Cross bridge formation -interaction between actin and myosin
Step 14
Cycling continues -as long as ATP and calcium are present
Step 5
Influx of sodium into the sarcolemma -makes it negatively charged
Step 11
Powerstroke -ADP and P (inorganic phosphate) release
Step 2
Trigger of voltage-gated calcium channels -influx of calcium into the axon terminal