Blood bank

What is syncope

fainting

The phase of the agglutination reaction is important in the interpretation of the antibody screen or antibody identification panel because it:

indicates the class of the antibody

An anti-Fya was identified in a patient's serum. The patient's red cells phenotyped as Fya positive using commercial antisera. The next step is to:

investigate a recent transfusion history

Testing for the weak D expression is performed by:

performing the indirect antiglobulin test with anti-D.

What is erythema

redness

The next step in investigating a positive direct antiglobulin test using polyspecific antihuman globulin reagent should be to:

repeat the direct antiglobulin test using monospecific anti-IgG and anti-C3 reagents.

The frequency of the D-negative phenotype in the population is:

15%

After adding antigen and antibody to a test tube, one large agglutinate was observed. How should this reaction be graded?

4+

In a family study, it was determined that all four siblings in the family had a different blood type: A, B, O, and AB. The parents were most likely ____________.

AO and BO

If all red cells tested at room temperature are positive with a patient's serum except for cord cells, the probable antibody identity is:

Anti-I

An anti-E was identified in a patient who recently received a transfusion. What other Rh system antibody should be investigated?

Anti-c

Anti-HPA-1a is a commonly identified ____________

Antibody

If all the panel cells were reactive at the same strength at the antihuman globulin phase, no negative reactions were observed, and the autocontrol was negative, what should be suspected?

Antibody to a high-frequency antigen

What is an Auto antibody

Attacks yourself

What is warm autoimmune hemolytic anemia (WAIHA)

Auto antibodies reacts optimally at 37 degrees c; commonly IgG

Match the Fisher-Race notation with the correct Weiner notation for the following: ry

CE

Match the Fisher-Race notation with the correct Weiner notation for the following: r'

Ce

Hemolysis was observed at room temperature when testing a patient's serum with reagent red cells used for screening. When this test was repeated using the patient's plasma, no hemolysis was observed. What was the most likely explanation for the different reactions?

Complement activation was inhibited by the lack of calcium in the plasma sample.

Match the Fisher-Race notation with the correct Weiner notation for the following: Rz

DCE

Match the Fisher-Race notation with the correct Weiner notation for the following: R0

Dce

Parents who are both phenotyped as group A cannot have a group O child. True or false

False

A patient's red cells are agglutinated by anti-B, but not by anti-A. This person would have which of the following ABO phenotypes?

Group B

Doner screening is done for?

Hep B, HIV, Hep C, HTLV, syphilis

What is urticaria

Hives

Antigen typing

Identifies which antigens patients RBC's lack

What immunoglobulin class? Found in secretions, such as breast milk

IgA

What immunoglobulin class? Associated with allergic reactions and mast cell activation

IgE

What immunoglobulin is associated with allergic reactions

IgE

What immunoglobulin class is capable of crossing the placenta?

IgG

What immunoglobulin class reacts best by antiglobulin testing?

IgG

What immunoglobulin class? Able to cross the placenta

IgG

What immunoglobulin class? Has the highest serum concentration

IgG

When testing for weak D using an indirect antigblobulin test (IAT), cells that are already coated with _____ can give a false-positive reaction in the antiglobulin phase.

IgG

Which class of antibodies is generally less efficient at activating complement but may cause extravascular hemolysis or destruction of the red blood cells outside the circulation?

IgG

What is paroxysmal cold hemoglobinuria (PCH)

IgG autoantibody against P carbohydrate antigen also known as biphasic hemolysin

Antibodies detected in the immediate spin crossmatch are usually of which of the following immunoglobulin classes?

IgM

What immunoglobulin class reacts best at room temperature at immediate spin?

IgM

What immunoglobulin class? Associated with immediate-spin in vitro reactions

IgM

What immunoglobulin class? Associated with intravascular cell destruction

IgM

What immunoglobulin class? Efficient in activation of the complement cascade

IgM

What immunoglobulin class? Has the highest number of antigen binding sites

IgM

What is hemosiderosis?

Iron overload

What is pruritus?

Itching

Epstein bar virus causes what?

Mono

Which condition is often associated with the presence of anti-I?

Mycoplasma pneumoniae infection

The children of an AB mother and a B father could phenotype as all of the following except:

O

What cell has the most H on it

O

What is an allo antibody

One you make to something you were exposed too

When an individual is said to be group A, it refers to the individual's:

Phenotype

What reagent contains antibodies to multiple antigenic epitopes?

Polyclonal-based

Each of the following genotypes is possible for an individual whose red cells react as indicated below except: ANTISERA REACTIONS anti-C + anti-D + anti-E + anti-c + anti-e +

R0r'

A patient phenotypes as D+C+E-c-e+. The most likely genotype is:

R1R1

Elution

Removing antibodies bound to RBC's

A fetal screen detects

Rh+ cells on an Rh- women

What is rigors?

Shaking/chills

What is conjunctival edema

Swelling

Absorption

Techniques that remove antibodies from plasma or serum to aid in detecting coexisting alloantibodies

Select the correct statement regarding the collection of a blood sample for compatibility testing.

The sample must be labeled at the bedside.

In an antibody identification panel, only one red cell was negative at the antihuman globulin phase. On ruling out and matching the pattern, an anti-k was identified. What further testing is necessary to confirm the antibody?

Two more k-negative cells should be tested

How would you interpret the results if both the anti-D reagent and the Rh control were 2+ agglutination reactions?

Unable to determine without further testing

Anti-D reagent and the Rh control were tested with red cells. Both tests were 2+ agglutination reactions. What is the interpretation of the results?

Unable to interpret without further testing

Immunoglobulins are roughly _____ -shaped molecules.

Y

A patient was admitted to the hospital with acute bleeding. Anti-E was detected in the patient's serum. Four E-negative units of blood were crossmatched for the patient. The units were compatible at immediate spin and following the antiglobulin test. After the antiglobulin test was performed, IgG-sensitized red cells gave a 2+ agglutination reaction. The proper interpretation of this 2+ agglutination reaction is the:

antihuman globulin washing procedure was adequate.