Bone development

7 days

"maturation" of newly formed (nonclassified) bone matrix takes about ________

secondary

______ ossification centers appear in. the epiphyses

cartilage

_______ bones develop from hyaline cartilage structures

mesenchyme periosteum

as it forms, a layer of vascular ______ condenses on the external face of the bone structure, forming a ______

periosteal bud

during endochondral ossification, the ______ invades the deteriorating hyaline cartilage shaft

hyaline cartilage

epiphysealplates are made of ______

woven diploe

eventually, lamellar bone replaces _____ bone, and the vascular tissue within the ______ differentiates into red marrow. the final results a fat bone

endosteal

in appositional growth, bone reabsorption occurs on the ______ surface

osteoblasts

large numbers of ______ are found in the inner periosteum layer

1. Perichondrium becomes vascularized to a greater degree and becomes a periosteum 2. collar of bone is laid down around the hyaline cartilage model just beneath the periosteum 3. cavity formation occurs within the hyaline cartilage 4. periosteal bud invades marrow cavity 5. osteoblasts lay down bone around the cartilage spicules in the bones interior 6. osteoclasts remove the spongy bone from the shaft interior, leaving a marrow cavity that then houses fat

name the events of the endochondral ossification process in order

calcium salts

the enzyme alkaline phosphatase encourages the deposit of _______ within the matrix of developing bone

trabeculae irregularly

the first network of _______ formed are arranged ______

mesenchymal cells ossification center

the first recognizable event is a clustering of the _______ to form an ________ in the fibrous membrane

mesenchymal cells

the initial supporting structure for this type of ossification is a fibrous membrane formed by ______

osteoid

the organic bone matrix is called the ______

osteoblasts osteoid

these cells then differentiate into _____, which begin secreting ______ around the fibers of the membrane

woven

this early membrane bone is referred to as _____ bone

intramembranous

when a bone forms from a fibrous membrane, the process is called _______ ossification

osteocytes

when trapped in lacunae, osteoblasts change into _______

mineralization bone matrix

within a few days, calcium salt deposits or ________ occurs, resulting in the formation of the _______ that surrounds the cells