Chapter 43
Which of the following statements is not true?
A lymphocyte has receptors for multiple different antigens.
Which statement best describes the difference in responses of effector B cells (plasma cells) and cytotoxic T cells?
B cells secrete antibodies against a pathogen; cytotoxic T cells kill pathogen-infected host cells.
The ability of one person to produce over a million different antibody molecules does not require over a million different genes; rather, this wide range of antibody production is due to
DNA rearrangements
An immune response to a tissue graft will differ from an immune response to a bacterium because
MHC molecules of the donor may stimulate rejection of the graft tissue, but bacteria lack MHC molecules.
A patient who can produce antibodies against some bacterial pathogens, but not against viral infections, probably has a disorder in his
T cells.
Bacterial infection in a previously uninfected house cat would most quickly activate its
Toll-like receptors that bind to lipopolysaccharides.
The complement system is
a group of antimicrobial proteins that act together in a cascade fashion.
A diseased patient is exposed to an unknown agent while out of the country. The patient's blood is found to have a high proportion of lymphocytes with CD8 surface proteins in her blood, a likely result of
a viral infection eliciting proliferation of CD8+ cytotoxic T cells.
Bacteria entering the body through a small cut in the skin
activate a group of proteins called complement
Which of these is not part of insect immunity
activation of natural killer cells
In some insects, such as Drosophila, fungal cell wall elements can activate the protein Toll, which
acts as a receptor that, when activated, signals synthesis of antimicrobial peptides
Clonal selection is an explanation for how
an antigen can provoke production of high levels of specific antibodies
A patient who has a parasitic worm infection and another patient responding to an allergen such as ragweed pollen have which of the following in common?
an increase in the levels of IgE
A patient who undergoes a high level of mast cell degranulation, dilation of blood vessels, and acute drop in blood pressure is likely suffering from
anaphylactic shock immediately following exposure to an allergen
Among the last line of defenses against prolonged exposure to an extracellular pathogen is
antibody production by plasma cells
The receptors on T cells and B cells bind to
antigens
Clonal selection implies that
antigens increase mitosis in specific lymphocytes.
Select the description that likely indicates a child with Bruton's disease.
baby boy Jeff, with no plasma cells following infection by bacterial pneumonia
A newborn who is accidentally given a drug that destroys the thymus would most likely
be unable to differentiate and mature T cells.
B cells have antigen receptors that bind to antigens that are either freely dissolved or present on the surface of invading/foreign cells. T cells have antigen receptors that
bind to antigens presented on major histocompatability complexes by host cells.
Preventing the appearance of the symptoms of an allergy attack would be the likely result of
blocking the attachment of the IgE antibodies to the mast cells.
Antihistamine treatment reduces
blood vessel dilation.
Select the pathway that would lead to the activation of cytotoxic T cells.
body cell becomes infected with a virus → new viral proteins appear → class I MHC molecule-antigen complex displayed on cell surface
Septic shock, a systemic response including high fever and low blood pressure, is a response to
certain bacterial infections.
The EBV antigen fragments will be presented by the virus-infected cells along with
class I MHC molecules.
Which of the following cells are involved in cell-mediated immunity and also respond to class I MHC molecule-antigen complexes?
cytotoxic T cells
An otherwise healthy student in your class is infected with EBV, the virus that causes infectious mononucleosis. The same student had already been infected when she was a child, at which time she had merely experienced a mild sore throat and swollen lymph nodes in her neck. This time, though infected, she does not get sick.
cytotoxic T cells.
The cell-mediated immunity that destroys virally infected cells involves
cytotoxic T cells.
T cells of the immune system include
cytotoxic and helper cells
The MHC is important in a T cell's ability to
distinguish self from nonself
Normal immune responses can be described as polyclonal because
diverse antibodies are produced for different
Mammals have Toll-like receptors (TLRs) that can recognize a kind of macromolecule that is absent from vertebrates but present in/on certain groups of pathogens, including viral
double-stranded RNA.
The number of MHC protein combinations possible in a given population is enormous. However, an individual in that diverse population has a far more limited array of MHC molecules because
each of the MHC genes has a large number of alleles, but each individual only inherits two for each gene
A bone marrow transplant may not be appropriate from a given donor (Jane) to a given recipient (Jane's cousin Bob), even though Jane has previously given blood for one of Bob's needed transfusions, because
even though Jane's blood type is a match to Bob's, her MHC proteins may not be a match.
Antigens are.
foreign molecules that trigger the generation of antibodies.
A cell type that interacts with both the humoral and cell-mediated immune pathways is a
helper T cell.
B cells interacting with helper T cells are stimulated to differentiate when
helper T cells release cytokines
An inflammation-causing signal released by mast cells at the site of an infection is
histamine
Antibodies of the different classes IgM, IgG, IgA, IgD, and IgE differ from each other
in their heavy-chain structure.
Inflammatory responses typically include
increased activity of phagocytes in an inflamed area.
Infection with HIV typically
increases the level of helper T cells for the first year after infection.
An individual who has been bitten by a poisonous snake that has a fast-acting toxin would likely benefit from
injection of antibodies to the toxin
Acidity in human urine is an example of
innate immunity
A nonfunctional CD4 protein on a helper T cell would result in the helper T cell being unable to
interact with a class II MHC-antigen complex.
The lymphatic fluid
is a filtrate of the blood, as is urine.
A fruit fly, internally infected by a potentially pathogenic fungus, is protected by
its antimicrobial peptides
Vaccination increases the number of
lymphocytes with receptors that can bind to the pathogen.
An invertebrate, such as an insect, has innate immunity activity in its intestine that likely includes
lysozyme.
The function of antibodies is to
mark pathogenic cells for destruction.
CD4 and CD8 are
molecules present on the surface of T cells where they interact with MHC molecules
Engulfing-phagocytic cells of innate immunity include all of the following except
natural killer cells
The cells involved in innate immunity, whose absence increases the chances of developing malignant tumors, are
natural killer cells.
An immunoglobulin (Ig) molecule, of whatever class, with regions symbolized as C or V, H or L, has a light chain made up of
one C region and one V region.
This type of immunity is present only when a newborn infant is being fed by actively nursing on its mother and ends when nursing ends.
passive immunity
Adaptive immunity depends on
pathogen-specific recognition.
Which of the following would not help a virus avoid triggering an adaptive immune response
producing proteins very similar to those of other viruses
Within a differentiated B cell, the rearrangement of DNA sequences between variable regions and joining regions is accomplished by
recombinase.
Histamines trigger dilation of nearby blood vessels as well as an increase in their permeability, producing
redness, heat, and swelling
Clonal selection of B cells activated by antigen exposure leads to production of
short-lived plasma cells that secrete antibodies for the antigen.
Infection by a bacterium that has elements on its surface that enhance its resistance to lysozyme will likely result in
successful reproduction of the bacterium and continued progression of the disease.
An epitope is
that part of an antigen that actually binds to an antigen receptor
Phagocytosis of microbes by macrophages is enhanced by
the binding of antibodies to the surface of microbes and antibody-mediated agglutination of microbes only.
Bruton's disorder will likely include
the failure of heavy-chain gene rearrangement in B cells.
The cells and signaling molecules that initiate inflammatory responses are
the mast cells and the histamines
Assume that a DGS-like phenotype was produced in a specific "gene-knockout" mouse, one lacking expression of HA3, a Hox gene known to be involved in developmental regulation in the mouse. The phenotype of the HA3 knockout can be ascertained by
the measurement of the proportion of CD4 cells to total lymphocytes.
Salmonella bacterial poisoning can be initiated when
the microbe survives the acidic environment of the stomach and resists lysosomal degradation in macrophages.
When antibodies bind antigens, the clumping of antigens results from
the multivalence of the antibody having at least two binding regions.
A key part of the humoral immune response is
the production of antibodies by plasma cells
The switch of one B cell from producing one class of antibody to another antibody class that is responsive to the same antigen is due to
the rearrangement of immunoglobulin heavy-chain C region DNA
In active immunity, but not passive immunity, there is
the requirement for direct exposure to a living or simulated pathogen
The eyes and the respiratory tract are both protected against infections by
the secretion of lysozyme onto their surfaces.
Which of the following should be the same in identical twins?
the set of MHC molecules produced
Most newly emerging diseases result in
the waning of the disease, due to evolutionary selection for resistant hosts and milder pathogens
Jenner's successful use of cowpox virus as a vaccine against the smallpox virus is due to the fact that
there are some antigenic determinants common to both pox viruses.
The primary function of humoral immunity is
to protect the body against extracellular pathogens.
An epitope associates with which part of an antigen receptor or antibody?
variable regions of a heavy chain and light chain combined
The activation of helper T cells is likely
when an antigen is displayed by a dendritic cell
