DNA, Lymphatic, Protein, Immune, Chemo/Anticancer, Erythropoietin
Which of the following is true of cancer cells?
Cancer cells have no useful function and cancer cells develop and reproduce at a faster rate than normal cells.
Monoclonal antibodies medications are adminstered in what dosage forms?
IV, injection
Which immunoglobulin is the main Ig in salivary and bronchial secretions?
IgA
What is the most common immuglobulin, making up about 80% of the total in plasma?
IgG
Which immunoglobulin is the most commonly used in the production of MAbs?
IgM
What is the advantage of recombinant DNA technology?
It can produce pure human protein in large quantities and It can produce pure human protein without the risk of viral contamination.
Which of the following statements about erythropoietin is true?
It is produced by the kidneys, The recombinant DNA product is known as epoetin alfa (Epogen, Procrit), Erythropoietin increases the production of red blood cells, and The drug should not be shaken, as this may denature the glycoprotein and inactivate it.
How would a pharmacy technician know that a drug is an monoclonal antibody?
The name of the drug ends in "mab."
Which of the following drugs is produced using recombinant DNA technology?
aldesleukin (Proleukin)
Which of the following cytoprotective drugs is used to reduce the side effects and toxicity of chemotherapy agents?
amifostine (Ethyol), dexrazoxane (Zinecard), and leucovorin
Which antirejection drug is a monoclonal antibody?
basiliximab (Simulect)
T cells and B cells both arise from the
bone marrow
Which immunity process is responsible for organ transplant rejection and hypersensitivity reactions?
cellular
Which class of recombinant DNA drugs is used to influence the bone marrow to produce blood cells?
colony-stimulating factor
Which drug is a secretion-thinning enzyme used in managing cystic fibrosis?
dornase alfa (Pulmozyme)
Drugs for the prevention of breast cancer recurrence attempt to intercept the production of
estrogen
What is another name for antihemophilic factor?
factor VIII
Which of the following hormones is incorrectly paired with the type of cancer it is used to treat?
flutamide (Eulexin) - breast
Which of the following drugs are useful against neoplasms of reproductive tissues?
hormones
Which biologic-response modifier has been approved for use in hairy cell leukemia?
interferon
Which of the following interferons is used to treat multiple sclerosis?
interferon beta-1b (Betaseron)
The protein that is extracted from pooled resources of human plasma tissues
is available in small quantities
What drug combination is known as "Magic Swizzle"?
lidocaine-diphenhydramine-Maalox
Where do T cells reside?
lymph nodes and spleen
Which of the following is not a drug that is used to prevent mucositis resulting from chemotherapy?
meperidine (Demerol)
Antitumor drugs are
most efficient when tumor cells are dividing rapidly, extremely toxic, and periodically stopped for two to six weeks.
What is a serious oral complication that can result from chemotherapy?
mucositis
Which of the following drugs is used to treat symptoms of organ rejection, although the first dose may cause severe pulmonary edema?
muromonab-CD3 (Orthoclone OKT3)
Neoplastic disease occurs when
normal cellular growth control mechanisms become altered.
Which drug listed below is indicated for ovarian cancer, should not be used in pregnant patients, and almost always causes hair loss?
paclitaxel (Taxol)
Which organ is not part of the lymphatic system?
pancreas
Which of the following drugs may be given to suppress infection and increase the production of white blood cells in patients receiving chemotherapy?
pegfilgrastim (Neulasta)
What term describes a small circular ring of DNA that can be used to transfer a gene to a host cell?
plasmid
What drug is used to treat Hodgkin disease?
procarbazine (Matulane)
What is the part of DNA where protein production starts?
promoter sequence
What are immunoglobulins?
proteins with antibody activity
What is defined as a technique that uses living organisms or parts of organisms for specific purposes?
recombinant DNA
Which term is used to describe the goal of most chemotherapy?
remission
What is the first step in creating a protein, based on a specific DNA sequence?
replication
A cytoprotective agent is also known as a(n)
rescue agent.
Which type of immune cells are memory cells?
small lymphocytes
What drug has the National Cancer Institute recommended oncologists to prescribe to patients for no more than five years?
tamoxifen (Nolvadex)
What is responsible for protein activity?
the folds and twists of amino acid chains into a three-dimensional shape
What is the purpose of the lymphatic system?
to filter body fluids by nodes, vessels, and lymphocytes before the fluids return to general circulation
The final step in the natural process for making proteins is
translation.
