Male Reproductive System

Fertilization

Fertilization is the process by which a sperm combines with an oocyte, or egg cell, to produce a fertilized zygote. The sperm released during ejaculation must first swim through the vagina and uterus and into the fallopian tubes where they may find an oocyte. After encountering the oocyte, sperm next have to penetrate the outer corona radiata and zona pellucida layers of the oocyte. Sperm contain enzymes in the acrosome region of the head that allow them to penetrate these layers. After penetrating the interior of the oocyte, the nuclei of these haploid cells fuse to form a diploid cell known as a zygote. The zygote cell begins cell division to form an embryo.

Semen

Semen is the fluid produced by males for sexual reproduction and is ejaculated out of the body during sexual intercourse. Semen contains sperm, the male reproductive gametes, along with a number of chemicals suspended in a liquid medium. The chemical composition of semen gives it a thick, sticky consistency and a slightly alkaline pH. These traits help semen to support reproduction by helping sperm to remain within the vagina after intercourse and to neutralize the acidic environment of the vagina. In healthy adult males, semen contains around 100 million sperm cells per milliliter. These sperm cells fertilize oocytes inside the female fallopian tubes.

Urethra

Semen passes from the ejaculatory duct to the exterior of the body via the urethra, an 8 to 10 inch long muscular tube. The urethra passes through the prostate and ends at the external urethral orifice located at the tip of the penis. Urine exiting the body from the urinary bladder also passes through the urethra.

Spermatogenesis

Spermatogenesis is the process of producing sperm and takes place in the testes and epididymis of adult males. Prior to puberty, there is no spermatogenesis due to the lack of hormonal triggers. At puberty, spermatogenesis begins when luteinizing hormone (LH) and follicle stimulating hormone (FSH) are produced. LH triggers the production of testosterone by the testes while FSH triggers the maturation of germ cells. Testosterone stimulates stem cells in the testes known as spermatogonium to undergo the process of developing into spermatocytes. Each diploid spermatocyte goes through the process of meiosis I and splits into 2 haploid secondary spermatocytes. The secondary spermatocytes go through meiosis II to form 4 haploid spermatid cells. The spermatid cells then go through a process known as spermiogenesis where they grow a flagellum and develop the structures of the sperm head. After spermiogenesis, the cell is finally a sperm cell, or spermatozoa. The spermatozoa are released into the epididymis where they complete their maturation and become able to move on their own.

Testes

The 2 testes, also known as testicles, are the male gonads responsible for the production of sperm and testosterone. The testes are ellipsoid glandular organs around 1.5 to 2 inches long and an inch in diameter. Each testis is found inside its own pouch on one side of the scrotum and is connected to the abdomen by a spermatic cord and cremaster muscle. The cremaster muscles contract and relax along with the scrotum to regulate the temperature of the testes. The inside of the testes is divided into small compartments known as lobules. Each lobule contains a section of seminiferous tubule lined with epithelial cells. These epithelial cells contain many stem cells that divide and form sperm cells through the process of spermatogenesis.

Cowper's Glands

The Cowper's glands, also known as the bulbourethral glands, are a pair of pea-sized exocrine glands located inferior to the prostate and anterior to the anus. The Cowper's glands secrete a thin alkaline fluid into the urethra that lubricates the urethra and neutralizes acid from urine remaining in the urethra after urination. This fluid enters the urethra during sexual arousal prior to ejaculation to prepare the urethra for the flow of semen.

Ejaculatory Duct

The ductus deferens passes through the prostate and joins with the urethra at a structure known as the ejaculatory duct. The ejaculatory duct contains the ducts from the seminal vesicles as well. During ejaculation, the ejaculatory duct opens and expels sperm and the secretions from the seminal vesicles into the urethra.

Epididymis

The epididymis is a sperm storage area that wraps around the superior and posterior edge of the testes. The epididymis is made up of several feet of long, thin tubules that are tightly coiled into a small mass. Sperm produced in the testes moves into the epididymis to mature before being passed on through the male reproductive organs. The length of the epididymis delays the release of the sperm and allows them time to mature.

Penis

The penis is the male external sexual organ located superior to the scrotum and inferior to the umbilicus. The penis is roughly cylindrical in shape and contains the urethra and the external opening of the urethra. Large pockets of erectile tissue in the penis allow it to fill with blood and become erect. The erection of the penis causes it to increase in size and become turgid. The function of the penis is to deliver semen into the vagina during sexual intercourse. In addition to its reproductive function, the penis also allows for the excretion of urine through the urethra to the exterior of the body.

Prostate

The prostate is a walnut-sized exocrine gland that borders the inferior end of the urinary bladder and surrounds the urethra. The prostate produces a large portion of the fluid that makes up semen. This fluid is milky white in color and contains enzymes, proteins, and other chemicals to support and protect sperm during ejaculation. The prostate also contains smooth muscle tissue that can constrict to prevent the flow of urine or semen.

Seminal Vesicles

The seminal vesicles are a pair of lumpy exocrine glands that store and produce some of the liquid portion of semen. The seminal vesicles are about 2 inches in length and located posterior to the urinary bladder and anterior to the rectum. The liquid produced by the seminal vesicles contains proteins and mucus and has an alkaline pH to help sperm survive in the acidic environment of the vagina. The liquid also contains fructose to feed sperm cells so that they survive long enough to fertilize the oocyte.

Spermatic Cords and Ductus Deferens

Within the scrotum, a pair of spermatic cords connects the testes to the abdominal cavity. The spermatic cords contain the ductus deferens along with nerves, veins, arteries, and lymphatic vessels that support the function of the testes. The ductus deferens, also known as the vas deferens, is a muscular tube that carries sperm superiorly from the epididymis into the abdominal cavity to the ejaculatory duct. The ductus deferens is wider in diameter than the epididymis and uses its internal space to store mature sperm. The smooth muscles of the walls of the ductus deferens are used to move sperm towards the ejaculatory duct through peristalsis.

Scrotum

The scrotum is a sac-like organ made of skin and muscles that houses the testes. It is located inferior to the penis in the pubic region. The scrotum is made up of 2 side-by-side pouches with a testis located in each pouch. The smooth muscles that make up the scrotum allow it to regulate the distance between the testes and the rest of the body. When the testes become too warm to support spermatogenesis, the scrotum relaxes to move the testes away from the body's heat. Conversely, the scrotum contracts to move the testes closer to the body's core heat when temperatures drop below the ideal range for spermatogenesis.