MediaLab BB Blood Group Systems-Genetcs
B. Caucasians
In which group is Type A blood found in higher frequency? A. African Americans B. Caucasians C. Asians D. Hispanics
B. Only to his daughters
If a father carried the Xga allele, to which of his children will he pass it along? A. Only to his sons B. Only to his daughters C. To all of his children D. Each child has the same probability of inheriting it
C. 6 units of type O RBC units
It's a busy Friday evening in the blood bank and you have been receiving a steady stream of Type & Screen specimens from the emergency room. Several of them have positive antibody screens which require further workup. One of these patients is a 46-year-old male whose hemoglobin has dropped from 8.4 g/dL to 4.6 g/dL in the previous 8 hours (normal Hgb for this patient demographic would be ~14 g/dL). Your workup reveals a group O patient with the following antibodies: anti-K, anti-Fya. The prevalence of K negative donors in your donor population is 91% while the prevalence of Fya negative donors is 37%. Two units of cross-matched RBCs are requested by the physician. How many units of group O RBC units should you phenotype in order to fulfill the request for two cross-matched units? A. 2 units of type O RBC units B. 3 units of type O RBC units C. 6 units of type O RBC units D. 12 units of type O RBC units
C. 75 - 80%
The A1 subgroup represents approximately what percentage of group A individuals? A. 25 - 30% B. 50 - 60% C. 75 - 80% D. 95 - 98%
C. Kell
The McLeod phenotype is associated with which of the following antigen systems? A. Rh B. P C. Kell D. MNSs
C. Fisher -Race
The Rh nomenclature which uses the letters DCE is found in which of the following genetic models? A. Wiener B. Shorthand C. Fisher -Race D. Rosenfield
C. Polymerase chain reaction-based assay
A patient, who recently received a transfusion of three units of red cells, is DAT-positive with an IgG specificity. What would be the best method to identify the patient's phenotype? A. Adsorption and elution B. Type and Screen C. Polymerase chain reaction-based assay D. Antigen typing
B. 15%
Approximately what percent of the Caucasian population is Rh negative? A. 10% B. 15% C. 25% D. 35%
D. N antigen
In immunohematology, an antithetical relationship exists between M antigen and which of these antigens? A. K antigen B. S antigen C. Lu6 antigen D. N antigen
A. Codominant
In the ABO blood group system, the A antigen is inherited in what relation to the B antigen? A. Codominant B. Dominant C. Recessive D. Amorphic
C. Asians
In which group is Type B blood found in higher frequency? A. African Americans B. Caucasians C. Asians D. Hispanics
C. Le(a+ b-)
Lewis Blood Group System is a human blood group unlike most others. The antigen is produced and secreted by exocrine glands, eventually adsorbing to the surface of red blood cells. Its expression is based on the genetic expression of the Lewis and Secretor genes. Based on the following genotype (Le) (sese), what would you predict the Lewis antigen phenotypic expression to be? A. Le(a- b-) B. Le(a+ b+) C. Le(a+ b-) D. Le(a- b+)
D. The lack of agglutination of patient red cells with anti-A reagent
The qualitative differences between A1 and A2 phenotypes includes all of the following EXCEPT: A. The formation of anti-A1 in A subgroups. B. The amount of transferase enzymes. C. The length of the precursor oligosaccharide chains. D. The lack of agglutination of patient red cells with anti-A reagent
C. Anti-U
The serum from a patient of African-American descent is reactive with all screening and panel cells. Which antibody directed to a high incidence antigen is most likely to be present? A. Anti-Lub B. Anti-Jk3. C. Anti-U D. Anti-Ku
A. HLA
What blood system is often tested to either establish or dispute paternity? A. HLA B. ABO C. Rh D. Duffy
C. Bombay phenotype
What does the hh genotype gives rise to? A. H substance B. H secretors C. Bombay phenotype D. h antibodies
B. R1R2
What is his MOST likely genotype for a white male who has the following Rh antigens C,c,D,E,e? A. R1r B. R1R2 C. Ror D. r'r"
B. DCe
What is the most common Rh haplotype among whites? A. Dce B. DCe C. DcE D. dce
C. rr
What is the most frequent genotype among Rho (D) negative persons? A. r'r B. r'r'' C. rr D. r''r
B. Leb
Which Lewis antigen(s) would be detected when phenotyping the red cells of an adult who has the Le, Se, and H genes? A. Lea B. Leb C. Both Lea and Leb D. Neither Lea or Leb
A. Bombay, A1B, A1, A2B, B, A2, O
Which is in the correct order from the lowest concentration of H antigen to the highest concentration of H antigen? A. Bombay, A1B, A1, A2B, B, A2, O B. A1, O, B, A2, Bombay, A1B, A2B C. Bombay, O, A1B, A2, A1, B, A2B D. A1B, A2B, A2, O, B, A1, Bombay
B. cDE/ce
Which of the following genotypes is found with the highest frequency in the Caucasian population? A. CDe/cDe B. cDE/ce C. cDE/cE D. CDe/ce
A. Two h genes are inherited at the H locus
Which of the following is true of the classic Bombay phenotype? A. Two h genes are inherited at the H locus B. H substance is present C. A antigen is present D. B antigen is present
C. 85%
Which of the following represents the approximate percentage of the Caucasian population that is Rh positive? A. 35% B. 65% C. 85% D. 95%
D. Le(a-b-)
Which one of these Lewis blood group system phenotypes usually produces anti-Lea? A. Le(a+b+) B. Le(a+b-) C. Le(a-b+) D. Le(a-b-)
C. N-acetyl-D-galactosamine
Which specific immunodominant sugar is responsible for A (blood group A) antigenic specificity? A. L-fucose B. D-galactose C. N-acetyl-D-galactosamine D. Glucose
B. D-galactose
Which specific immunodominant sugar is responsible for B (blood group B) antigenic specificity? A. L-fucose B. D-galactose C. N-acetyl-D-galactosamine D. Glucose
A. L-fucose
Which specific immunodominant sugar is responsible for O (blood group O) antigenic specificity? A. L-fucose B. D-galactose C. N-acetyl-D-galactosamine D. Glucose
B. 30,000
Approximately how many out of 1,000,000 Caucasians will have the following phenotype?Group 0, K+, Jk(a+) A. 10,000 B. 30,000 C. 100,000 D. 600,000