Pathophysiology -Amyotrophic lateral sclerosis (ALS)
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What is the life expectancy after diagnosis of ALS?
3-5 years
Is ALS an upper motor neuron lesion or a lower motor neuron lesion?
BOTH
What is ALS?
Degenerative changes in anterior horn cells of the spinal cord and brain
What is ALS also known as
Lou Gehrig's disease
When does ALS present?
Midlife, 40 to 60, more often in men
What is the etiology of ALS?
Unknown, however there are several theories such as hereditary, a combination of oxidative stress, exogenous neurotoxicity, excitotoxicity....
Is ALS progressive?
Yes, progressive muscle weakness
