Pharmaceutics Exam 2 Calculation Example Questions

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A pharmacist receives a prescription for 15 mg piroxicam capsules, #48. A size 1 capsule filled with piroxicam weighs 245 mg; a capsule filled with lactose weighs 180 mg. How much piroxicam and lactose are required for the prescription? Prepare sufficient powder for 50 capsules (2 extra). A) 15 mg piroxicam + 165 mg lactose B) 750 mg piroxicam + 8.45 g lactose C) 750 mg piroxicam + 9 g lactose D) 15 mg piroxicam + 230 mg lactose E) none of the above

B) 750 mg piroxicam + 8.45 g lactose

1. _________ drug is bound to a resin and released due to changes in pH 2. _________ drug is compressed into tablets with a slowly soluble polymer 3. _________ drug is compressed into tablet with an insoluble polymer 4. _________ drug is compressed into tablets with semipermeable membrane and laser drilled hole through which drug is transported out by convective flow A) encapsulated dissolution B) ion-exchange C) matrix diffusion D) matrix dissolution E) osmotic pumping

1. B) ion-exchange 2. D) matrix dissolution 3. C) matrix diffusion 4. E) osmotic pumping

Consider the basic tablet coating solution formula below and state the function of each ingredient 1. HPMC 2. PEG 3. iron oxide yellow 4. titanium dioxide 5. purified water

1. main coating agent 2. plasticizer 3. colorant 4. opacifier 5. vehicle

Which of the following capsule sizes has the largest capacity? A) 000 B) 5 C) 0 D) 4 E) 1

A) 000

The rectal route of administration of drug may be preferred over the oral route for some systemic-action because A) a portion of the absorbed drug does not pass through the liver before entering the systemic circulation B) the drug does not have to be absorbed C) the dissolution process is avoided D) inert binder, diluents, and excipients cannot interfere with absorption E) absorption is predictable and complete

A) a portion of the absorbed drug does not pass through the liver before entering the systemic circulation

Most commercial vaginal suppositories use a base of A) polyethylene glycol B) glycerin C) beeswax D) cocoa butter E) glycerinated gelatin

A) polyethylene glycol

The shells of soft gelatin capsules may be made elastic or plastic by the addition of? A) sorbitol B) HPMC C) povidone D) polyethylene glycol

A) sorbitol

Which of the following statements is NOT TRUE about modified-release drug products? A) advising patients not chew on these products during administration B) advising patients to drink a full glass of alcohol with these medications for better absorption C) advising patients not to crush these products to maintain their physical integrity D) they are commercially available in various solid dosage forms: ER tablets or capsule E) delayed release products are not bioequivalent to extended release product for the same active ingredient

B) advising patients to drink a full glass of alcohol with these medications for better absorption

Agents that might be used to coat enteric-coated tablets include: I. hydroxypropyl methylcellulose (HPMC) II. caroxymethylcellulose (CMC) III. cellulose acetate phthalate (CAP) A) if I only is correct B) if III only is correct C) if I and II are correct D) if II and III are correct E) if I, II, and III are correct

B) if III only is correct

Hydroxychloroquine (PlaquenilÒ) is considered a disease-modifying antirheumatic drug (DMARD). It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat RA, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine may also be used to treat coronavirus (COVID-19) in certain hospitalized patients. Description: Active pharmaceutical ingredient (API): The molecular weight of hydroxychloroquine sulfate is 433.95, and molecular formula is C18H26ClN3O.H2SO4. PLAQUENIL (hydroxychloroquine sulfate) tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. Inactive Ingredients: Dibasic calcium phosphate USP, hypromellose USP, magnesium stearate NF, polyethylene glycol 400 NF, polysorbate 80 NF, corn starch, titanium dioxide USP, carnauba wax NF, shellac NF, black iron oxide NF. In this formulation magnesium stearate is used as A) disintegrant B) lubricant C) opacifier D) filler or diluent E) binder

B) lubricant

Considering this "secret" formula and procedure, the amount of acetaminophen (in kg) required to produce 1 million Tylenol tablets is A) 0.5 kg B) 5 kg C) 500 kg D) 500,000 kg

C) 500 kg

If the API of 125 mg tablet decays by zero-order kinetics with a reaction rate constant kinetic of 0.5 mg per hour, what is the amount of intact drug remaining after 3 days (72 hours)? A) 0.89 mg B) 8.9 mg C) 89 mg D) 890 mg

C) 89 mg

High bloom strength gelatin is used in the manufacturing of? I. soft gelatin capsules II. hard gelatin capsules III. none of the above A) if I only is correct B) if III only is correct C) if I and II are correct D) if II and III are correct E) if I, II, and III are correct

C) if I and II are correct

True statements about the function of excipients used in tablet formulations include: I. binders promote granulation during the wet granulation process II. gildants help to promote the flow of the tablet granulation during manufacture III. lubricants help the patient to swallow the tablets A) if I only is correct B) if III only is correct C) if I and II are correct D) if II and III are correct E) if I, II, and III are correct

C) if I and II are correct

The respective amount of zinc oxide and cocoa butter required to make these 12 suppositories is _______ respectively. A) 0.36 g, 2.3 g B) 3.6 g, 2.3 g C) 0.36 g, 23 g D) 3.6 g, 23 g E) 3.6 g, 24 g

D) 3.6 g, 23 g

Manufacturing variables that would likely affect the dissolution of a prednisone tablet in the body include: I. the amount and type of binder added II. the amount and type of disintegrant added III. the force of compression used during tableting A) if I only is correct B) if II and III are correct C) if I and II are correct D) if I, II, and III are correct E) if III only is correct

D) if I, II, and III are correct

Advantages to the manufacturer for tablet film coating when compared to sugar coating include: I. shorter production times II. less gross weight III. lower incidence in coat chipping A) if I only is correct B) if III only is correct C) if I and II are correct D) if II and III are correct E) if I, II, and III are correct

E) if I, II, and III are correct

Which of the following are steps involved in hard gelatin capsule shells production? I. dipping II. spinning III. trimming A) if I only is correct B) if III only is correct C) if I and II are correct D) if II and III are correct E) if I, II, and III are correct

E) if I, II, and III are correct

A satisfactory suppository base must meet all of the following criteria EXCEPT A) it should be nonirritating and non-sensitizing B) it should dissolve or disintegrate rapidly in the body cavity C) it should have a narrow melting range D) it should be inert E) it should melt below 30 degrees Celsius

E) it should melt below 30 degrees Celsius


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