Pharmaceutics Exam II Case Study Questions

What role does the ingredient hydrated silica have? a.Water absorbant b.Disintegrate c.Active pharmaceutical ingredient d.Binder

a.Water absorbant

1.What is the main role of the sugar spheres in Metadate CD capsules? a. API b. Filler c. Disintegrant d. Solution Binder

b. Filler

What is the ingredient croscarmellose sodium used for in making acetaminophen tablets? A. Disintegrant B. Filler C. Solubilizer D. Coloring Agent

A. Disintegrant --Note: Disintegrants facilitate water penetration inside solid dosage form leading to their disintegration into initial tiny granules

Vyvanse is a Prodrug that gets metabolized into what 2 metabolites? A: d-amphetamine + l-lysine B: l-amphetamine + d-amphetamine C: d-amphetamine + v-lysine D: l-amphetamine + l-lysin

A: d-amphetamine + l-lysine -- Note: This emphasize the nature and chemistry of certain APIs.

What is the Active Pharmaceutical Ingredient (API) in Oxecta? A.Magnesium Stearate B.Oxycodone Hydrochloride C.Crospovidone D.Polyethylene Oxide

B.Oxycodone Hydrochloride

Which method of tablet production is used to make acetaminophen tablets? A. Direct Compression B. Dry Granulation C. Wet Granulation D. All of the above

C. Wet Granulation

What is the point of advice that is TRUE for patients taking Oxecta? A.Alcohol use is not an issue when taking Oxecta. B.It is okay to crush the tablet if the patient has a hard time swallowing pills. C.Oxecta should never be stopped abruptly. D.If a dose is missed, take it with the next dose.

C.Oxecta should never be stopped abruptly.

A major benefit of Rhopressa as an opthalmic solution include all the following EXCEPT? A) A half-life long enough to allow once daily administration B) Localization to the eye because of selective metabolites C) Decreased systemic absorption D) Increased systemic absorption E) Ingredients bypass first pass metabolism

D) Increased systemic absorption

What is the role of the benzalkonium chloride in the preparation of Rhopressa solution? A) lubricant B) wetting agent C) pore-forming agent D) antibacterial preservative E) diluent

D) antibacterial preservative

What is the role of talc in the formulation of Danazol hard capsules? a. To ensure disintegration of powder mixture (disintegrant) b. Improve powder flow properties (glidant) c. Improved flow properties and reduced powder adhesion to metal parts (lubricant) d. Improve plug formation and compression (diluent)

b. Improve powder flow properties (glidant)

What is the therapeutic class of Nurtec? a. Agent for Gout b. Treatment of acute migraine c. Antihypertensive d. Analgesic

b. Treatment of acute migraine

Which method involves dissolving the API into a melted base and then transferring the ingredients into molds? a.Dry granulation b.Fusion molding c.Direct compression d.Wet granulation

b.Fusion molding

What is an advantage of Lamprene dosage form (soft gelatin capsule)? a.Less expense to formulate b.Increased bioavailability c.Increased stability d.All of the above

b.Increased bioavailability

What is the purpose of the PEG hydrogel in Dextenza? a.Colorant b.Vehicle c.Buffering agent d.Opacifier

b.Vehicle

Which of the following is the best option for storage of Suboxone? a) Store in cold, damp area with little sunlight b) Store in fridge c) Store in dry, room temperature places d) Store in cold, dry area with little sunlight

c) Store in dry, room temperature places

Which of these is the primary reason for why it is possible for Vyvanse to have a chewable dosage form? a. Because it contains no excipients b. Because it is white in color c. Because it is not metabolized into its active form until after it is absorbed by the gut d. Because it is small in size

c. Because it is not metabolized into its active form until after it is absorbed by the gut

What is the mechanism of action of Nurtec? a. Opioid receptor agonist b. Inhibits prostaglandin synthesis through inhibition of cyclooxygenases c. Calcitonin-gene related peptide receptor antagonist d. Inhibits xanthine oxidase

c. Calcitonin-gene related peptide receptor antagonist --not very well-aligned with the specific learning objectives of this course.

The ingredients "titanium dioxide" and "yellow ferric oxide" act as __________________ in the formulation of Avigan tablets. a. Surfactants b. Sweeteners c. Colorants d. Plasticizers

c. Colorants -- Note: These ingredients are generally recognized by their name FDC#

Which of the following characteristics/effects of Danazol is correct? a. Stimulates an overall increase to estrogen production b. Danazol has been found to have low permeability and high solubility c. Effect on pituitary gland, which results in reduced FSH and LH production d. Used to increase the growth rate of breast tissue

c. Effect on pituitary gland, which results in reduced FSH and LH production

Which ingredient is essential in the controlled release timing of Lamprene (soft gelatin capsule)? a.Citric acid b.Parabens c.Beeswax d.Ethyl vanillin

c.Beeswax --Note: But the underlying mechanism in this case is unclear. Traditionally beewax is simply used for polishing capsules for improved appearance.

What is the indication for Dextenza? a.Conjunctivitis b.Corneal laceration c.Post-op ophthalmic surgery inflammation of the eye and pain d.Fungal infection of the eye

c.Post-op ophthalmic surgery inflammation of the eye and pain -- But it is not very well aligned with the specific learning objectives of this course

Which of the following describes proper storage techniques for Annovera? a.Store in direct sunlight b.Store in a freezer or refrigerator c.Store at room temperature d.Store very high temperatures

c.Store at room temperature

What are the advantages to using suboxone sublingual films? a) They have increased bioavailability as compared to the SL tablets b) You can take a much lower dose when switching from SL tablets c) They help to deter abuse d) Both A and C are correct answers

d) Both A and C are correct answers

Why is Metadate CD preferred over IR Formulations of Methylphenidate HCl? a. Higher adherence b. Once a day dosing instead of multiple times per day c. Less fluctuation of plasma concentration d. All of the Above

d. All of the Above

Hydrocholorquine FDA Approved indications includes: a. Malaria b. Rheumatoid arthritis c. Systemic lupus erythematous d. All of the above

d. All of the above

Which statement is true? a. The capsule formulation of Avigan increases bioavailability b. The capsule formulation of Avigan decreases bioavailability c. The tablet formulation of Avigan increases bioavailability d. No change in bioavailability between capsule and tablet formulations

d. No change in bioavailability between capsule and tablet formulations

What is the use of titanium dioxide in Hydrochloroquine tablets? a. Binder b. Coating agent c. Lubricant d. Prevent light degradation

d. Prevent light degradation -- Note: light degradation is also technically called "photodegration" in this field

Which of the following best describes the correct length of effectiveness of one Annovera? a.1 month b.3 months c.6 months d.1 year

d.1 year

What purpose does silicon dioxide serve in Anusol-HC®? a.Viscosity agent b.Slow dispersion of API in the body c.Excipient d.All of the above

d.All of the above

How is cleocin formulated? a.Film coating method b.Wet granulation c.Hard gelatin capsule d.Fusion molding

d.Fusion molding