Week 4 Quiz

All but one of the following is true about systemic lupus erythematosus A) Affects bones and joints exclusively B) Is usually found in young women C) Commonly present with joint pain D) Is diagnosed by the presence of serum antibodies to DNA

A) Affects bones and joints exclusively

In certain disease state, antibodies are made to self-antigens. This entity is known as: A) Autoimmune disease B) Graft versus host disease C) Anaphylaxis D) Acquired Immunodeficiency Syndrome

A) Autoimmune disease

"Initiation" and "promotion" are terms used in: A) Chemical carcinogenesis B) Radiant energy carcinogenesis C) Oncogenic virus-associated carcinogenesis D) None of the above

A) Chemical carcinogenesis

Proto-oncogenes are: A) Genes that control proliferation B) Genes that regulate apoptosis C) Genes that only stop uncontrolled cell growth D) Genes that repair DNA

A) Genes that control proliferation

Which of the following neoplasms has the highest mortality rate in women? A) Carcinoma of the colon B) Carcinoma of the lung C) Carcinoma of the uterus D) Carcinoma of the breast

B) Carcinoma of the lung

Susceptibility to cancer is determined by: A) Dietary factors B) Combination of genetic and environmental factors C) Deficiency of DNA repair enzymes D) Low levels of activity of tumor suppressor genes

B) Combination of genetic and environmental factors

Infection of a cell by some viruses result in the expression of a viral gene that may cause cancerous changes in the cell. The viral gene is known as a/an: A) Chemical carcinogen B) DNA or RNA onogene C) Mutant D) Growth factor

B) DNA or RNA oncogene

Which of the following diseases is not autoimmune? A) Antiglomerular basement membrane disease B) Hereditary spherocytosis C) Rheumatoid arthritis D) Systemic lupus erythematosus

B) Hereditary spherocytosis

Blood from persons with rheumatoid arthritis often contains the rheumatoid factor (RF); this factor is a/an: A) Antibody native to DNA B) IgM antibody directed against self IgG C) Abnormal T lymphocyte D) Cell-bound antigen and antibody complex

B) IgM antibody directed against self IgG

A benign neoplasm may cause health problems because of all of the following except: A) It may interfere locally with the function of vital organs B) It may mestastisize C) It may produce biologically active substances (hormones) D) It may cause pain after enlargement

B) It may metastasize

In anti-glomerular basement membrane disease the antibodies may cross react with an antigen, causing significant disease, in which of the following: A) Liver B) Lung C) Brain D) Skin

B) Lung

An in-situ carcinoma is a/an: A) Benign process B) Malignant process at a very early stage C) Invariably fatal condition D) Associated with metastases

B) Malignant process at a very early stage

Neoplasia is: A) Deviation from the typical normal tissue structure - alteration in size, shape, and organization B) New growth or formation of new tissue C) Similarity of the new tissue to the original tissue D) Loss of similarity of new tissue as compared with the original tissue

B) New growth or formation of new tissue

Dysplasia is: A) Similarity of the new tissue to the original tissue B) New growth or formation of new tissue C) Abnormal proliferation of cells plus loss of maturation D) The study of tumors or neoplasms

C) Abnormal proliferation of cells plus loss of maturation

Which of the following in not true about systemic lupus erythematosus? A) Is associated with multiple organ systems B) Patients are more often women C) Anti-cyclic citrullinated peptide (anti-CCP) is a very specific lab tset D) Is often associated with a skin rash and joint pain

C) Anti-cyclic citrullinated peptide (anti-CCP) is a very specific lab t-test

Which statement regarding autoimmunity is true? A) Autoimmune diseases are very uncommon B) Only one organ system at a time is involved during autoimmune disease C) Auto reactive lymphocytes are present in normal people D) There is no known genetic basis to any autoimmune disease

C) Auto reactive lymphocytes are present in normal people

The grade of a neoplasm is determined by: A) Presence or absence of blood-borne metastasis B) Extension of spread to regional lymph nodes C) Degree of differentiation of the tumor cells D) Measuring the size of the primary tumor

C) Degree of differentiation of the tumor

Which of the following viruses is thought to be causally related to hepatocellular carcinoma? A) Epstein-Barr virus B) Papilloma virus C) Hepatitis B virus D) Human T-cell leukemia virus

C) Hepatitis B virus

A malignant neoplasm of fatty tissue is a: A) Fibrosarcoma B) Fibroma C) Liposarcoma D) Lipoma

C) Liposarcoma

Excessive long term sun exposure may cause which of the following: A) Psoriasis B) Osteoporosis C) Squamous cell carcinoma D) Seborrheic dermatitis

C) Squamous cell carcinoma

Benign tumors are characterized as: A) Showing necrosis B) Not being well-differentiated C) Invading local blood vessels D) Absences of metastases

D) Absences of metastases

An example of a remote or distant complication of tumors is: A) Metastasis to vital organs B) Elaboration of hormones by the tumor in endocrine neoplasms C) Paraneoplastic syndromes D) All of the above

D) All of the above

In systemic lupus erythematosus, which of the following may be present as a result of an autoantibody response in the patient? A) Anemia B) Arthritis C) Renal disease D) All of the above

D) All of the above

Which of the following has been implicated in malignant neoplasia? A) Chemotherapy B) Excessive sun exposure C) Epstein-Barr virus D) All of the above

D) All of the above

Of new cancer cases, which of the following has the estimated highest incidence for females? A) Colon/rectal B) Lung C) Stomach D) Breast

D) Breast

Which of the following statements is the most accurate for the relationship of dysplasia to carcinoma? A) Carcinoma is always preceded by dysplasia B) Dysplasia is inevitably followed by carcinoma C) Carcinoma and dysplasia always coexist D) Dysplasia is associated with risk for carcinoma

D) Dysplasia is associated with risk for carcinoma

A benign neoplasm of fibrous connective tissue is known as: A) Myoma B) Fibrosarcoma C) Fibroadenoma D) Fibroma

D) Fibroma

A benign neoplasm of fatty tissue is a: A) Fibroma B) Adenoma C) Liposarcoma D) Lipoma

D) Lipoma

Considering the known causes of cancer, which of the following cancers is most preventable? A) Cervix B) Breast C) Colon D) Lung

D) Lung

The stage of a malignant neoplasm is determined by all of the following except: A) Size of the tumor B) Metastases to distant organs C) Metastases to local lymph nodes D) The differentiation of the tumor cells

D) The differentiation of the tumor cells