AP Biology midterm
Simple cuboidal epithelial cells line the ducts of certain human exocrine glands. Various materials are transported into or out of the cells by diffusion. (The formula for the surface area of a cube is 6 X S2, and the formula for the volume of a cube is S3, where S = the length of a side of the cube.) Which of the following cube-shaped cells would be most efficient in removing waste by diffusion?
10 um
A net movement of water into the beaker occurs in which of the following dialysis tubes?
6
Figure 1. The average amount of time spent by a particular type of eukaryotic cell in each phase of the cell cycle Based on Figure 1, what percent of the time required to complete a full cycle do the cells typically spend in interphase?
95%
Which of the following describes a metabolic consequence of a shortage of oxygen in muscle cells?
A buildup of lactic acid in the muscle tissue due to fermentation
Which of the following best describes the formation of the bond shown in Figure 1 ? (peptide bond)
A covalent bond is formed between a carbon atom and a nitrogen atom along with the formation of H2OH2O .
Cancer can result from a variety of different mutational events. Which of the following is LEAST likely to result in the initiation of a cancerous tumor?
A defect in a cell-cycle checkpoint prevents a cell from entering the S phase.
The mechanism of action of many common medications involves interfering with the normal pathways that cells use to respond to hormone signals. Which of the following best describes a drug interaction that directly interferes with a signal transduction pathway?
A medication enters the target cell and inhibits an enzyme that normally synthesizes a second messenger.
The figure above shows a model of a ligand precursor being cleaved to produce an active ligand that binds to a specific receptor. Which of the following is most likely to reduce the binding of the active ligand to its receptor?
A mutation in the receptor gene that causes a substitution of a charged amino acid for a nonpolar amino acid in the ligand binding site of the receptor
Site of conversion of chemical energy of glucose to ATP
A, mitochondria
In mammals, an increase in the concentration of sodium in the blood triggers the release of antidiuretic hormone (ADH) from the pituitary gland. As the concentration of sodium in the blood returns to previous levels, the release of ADH from the pituitary gland is reduced. Based on the information presented, which of the following describes the most likely role of ADH in maintaining blood osmolarity?
ADH promotes an increase in the movement of water into the bloodstream.
The energy required to run the Calvin cycle reactions of photosynthesis comes from which two substances produced during the light-dependent reactions?
ATP and NADPH
A researcher claims that the synthesis of ATP from ADP and inorganic phosphate (Pi) is essential to cellular function. Which of the following statements best helps justify the researcher's claim?
ATP hydrolysis is an energy-releasing reaction that is often coupled with reactions that require an input of energy.
Figure 1. ATP production by three metabolic pathways following the start of an intense period of exercise Which of the following correctly uses the data to justify the claim that the phosphagen system is an immediate, short-term source of ATP for muscle cells?
ATP production by the phosphagen system increases and decreases rapidly following the start of the exercise period.
Figure 1. A section of a cell's plasma membrane, showing a channel protein and a concentration gradient across the membrane An investigator wants to understand whether a newly found membrane protein is involved in membrane transport of a certain particle. Which investigation will help determine whether the new membrane protein is a channel protein involved in membrane transport?
Add more of the proteins to the plasma membrane and measure the rate of the particle movement.
The endocrine system incorporates feedback mechanisms that maintain homeostasis. Which of the following demonstrates negative feedback by the endocrine system?
After a meal, blood glucose levels become elevated, stimulating beta cells of the pancreas to release insulin into the blood. Excess glucose is then converted to glycogen in the liver, reducing blood glucose levels.
Which of the following best describes the numbered areas? (phospholipid bilayer)
Areas 1 and 3 are polar, since the membrane molecules are aligned with water molecules.
A researcher claims that only a portion of the light energy captured by green plants is available for growth and repair. Which of the following observations best helps justify the researcher's claim?
As light energy is converted to chemical energy by metabolic processes, some of the energy is lost as heat.
Antidiuretic hormone (ADH) is important in maintaining homeostasis in mammals. ADH is released from the hypothalamus in response to high tissue osmolarity. In response to ADH, the collecting duct and distal tubule in the kidney become more permeable to water, which increases water reabsorption into the capillaries. The amount of hormone released is controlled by a negative feedback loop. Based on the model presented, which of the following statements expresses the proper relationship between osmolarity, ADH release, and urine production?
As tissue osmolarity rises, more ADH is released, causing less water to be excreted as urine.
A researcher claims that increased atmospheric carbon dioxide levels cause increased growth rates in plants. Which of the following statements best supports the researcher's claim?
Atmospheric carbon dioxide is the raw material for photosynthesis, which plants rely on for producing sugars and other organic compounds.
Directions: This group of questions consists of five lettered headings followed by a list of phrases or sentences. For each phrase or sentence, select the one heading to which it is most closely related. Each heading may be used once, more than once, or not at all. (A) Glysolysis(B) Krebs cycle (citric acid cycle)(C) Calvin cycle (light-independent reactions of photosynthesis)(D) Light-dependent reactions of photosynthesis(E) Chemiosmosis Process in which CO2, is released as a by-product of oxidation-reduction reactions
B
The following questions refer to the following diagram. For each phrase or sentence, select the labeled part to which it is most closely related. Each option may be used once, more than once, or not at all for each group. Site of glucose synthesis
B, chloroplasts
An increase in the rate of oxygen production by algae would be accompanied by a comparable increase in the rate of production of which of the following substances?
C6H12O6
Bacteriophages are viruses that infect bacteria. In an experiment, bacteriophages were labeled with either radioactive phosphorus or radioactive sulfur. The labeled bacteriophages were incubated with bacteria for a brief amount of time and then removed. The infected bacteria cells were found to contain significant amounts of radioactive phosphorus but not radioactive sulfur. Based on the results of the experiment, which of the following types of molecules did the bacteriophages most likely inject into the bacteria cells?
DNA
Which of the following best describes the role of mitosis in the cell cycle?
Distributing replicated chromosomes to daughter nuclei
The figures below illustrate the similarities between ATP synthesis in mitochondria and chloroplasts. The figures can best assist in answering which of the following questions?
Do electron transport chains create a gradient so that ATP synthase can generate ATP molecules?
The enzyme hexokinase catalyzes the conversion of glucose to glucose-6-phosphate, which is an important step in glycolysis. The reaction involves the transfer of a phosphate group from ATP to glucose. Either a glucose molecule or a water molecule can fit in the active site of hexokinase. The presence of a water molecule in hexokinase's active site would result in the hydrolysis of ATP to ADP instead of the conversion of glucose to glucose-6-phosphate. Which of the following statements best helps explain the reaction specificity of hexokinase?
Glucose has the right shape and charge to cause hexokinase to undergo a structural change needed for catalysis, whereas water does not.
Figure 1. A simplified model of the epinephrine signaling pathway in muscle cells A researcher claims that the epinephrine signaling pathway controls a catabolic process in muscle cells. Which of the following statements best helps justify the researcher's claim?
Glycogen phosphorylase catalyzes the conversion of glycogen to glucose-1-phosphate.
For following group of questions first study the description of the situation or data and then choose the one best answer to each question following it and fill in the corresponding oval on the answer sheet. In the first step of an experiment, rat liver cells were exposed for 5 minutes to amino acids labeled with a radioactive isotope. The cells were then washed to stop any further incorporation of radioactive amino acids. The cells were sampled periodically thereafter, and the radioactivity of a certain protein (protein X) was measured in various cell components, as shown below. The same procedure was repeated with a second protein (protein Y). If the function of Y is protein processing and packaging, the most radioactivity would be found in the
Golgi apparatus
Liver cells manufacture glycoproteins, while adipose cells store fat. Which of the following subcellular structures is likely to be more prominent in liver cells than in adipose cells?
Golgi apparatus
Which of the following statements accurately uses the information presented to support the hypothesis that interruption of M function in a single body cell can result in cancer?
Growth-factor signaling can trigger mitosis in cells that are in direct contact with other cells.
Which of the following correctly illustrates a dipeptide and an amino acid in the optimal position to form a tripeptide?
H at the beginning, fork at the end (for both)
The CFTR protein is made up of 1,4801,480 amino acids linked together in a chain. Some humans produce a version of the CFTR protein in which phenylalanine (an amino acid) has been deleted from position 508 of the amino acid chain. Which of the following best predicts how the amino acid deletion will affect the structure of the CFTR protein?
It will affect the primary, secondary, and tertiary structures of the CFTRCFTR protein.
The function of which of the following organelles directly requires oxygen?
Mitochondria
Changing the shape or morphology of the mitochondrial inner membrane can change the efficiency of mitochondrial function. Which of the following outcomes will most likely result from a change in the shape of the mitochondrial inner membrane from a highly folded surface to a smooth, flat surface?
Mitochondria will become less efficient because the surface area of the inner mitochondrial membranes will decrease.
Figure 1. Model of erythrocyte production control Air is less dense at very high elevations, so less oxygen is available than in the denser air at sea level. Based on the model in Figure 1, if a person travels from sea level to a high elevation location, which of the following correctly predicts the response to the decreased blood oxygen level?
More erythropoietin will be secreted from the kidneys, increasing production of erythrocytes.
Which of the following conclusions is most clearly supported by the representations of nucleic acid #1 and nucleic acid #2 ?
Nucleic acid #1#1 contains adenine-thymine base pairs, whereas nucleic acid #2#2 does not.
Directions: This group of questions consists of five lettered headings followed by a list of phrases or sentences. For each phrase or sentence, select the one heading to which it is most closely related. Each heading may be used once, more than once, or not at all. This group of questions refers to the following groups of biological compounds. (A) Proteins(B) Carbohydrates(C) Nucleic acids(D) Lipids(E) Steroids Used to carry the genetic code
Nucleic acids
The molecular structures of linoleic acid and palmitic acid, two naturally occurring substances, are shown in the figure. Based on the molecular structures shown in the figure, which molecule is likely to be solid at room temperature?
Palmitic acid, because the absence of carbon-carbon double bonds allows the molecules to pack closely together.
Which of the following statements best explains the processes of passive and active transport?
Passive transport is the net movement of substances down a concentration gradient that does not require metabolic energy. Active transport is the movement of substances up a concentration gradient that requires energy.
The student decreased the intensity of the light hourly and recorded the corresponding changes in oxygen concentration. The graph below shows the results from the recording device. Based on the data shown, changes in the light intensity resulted in changes in the rate of which of the following processes?
Photosynthesis
What most likely causes the trends in oxygen concentration shown in the graph above? (oxygen concentration in the water of a lake)
Photosynthesis produces more oxygen than is consumed by respiration during the day.
Steroid hormones, such as testosterone, pass through the plasma membrane and bind to an intracellular protein, as shown in the diagram below. The hormone-receptor complex then enters the nucleus, where it interacts with DNA to promote transcription of a specific gene. Based on the information presented, which of the following will also occur in response to steroid signaling?
Production of a specific mRNA will increase as a result of the binding of the hormone-receptor complex to the DNA
During mitosis, which of the following normally occurs?
Replicated chromosomes line up on the equatorial plate.
Cells contain smaller components called organelles that are necessary for a cell's survival. Organelle functions have often been compared to components of larger systems. Which of the following functional differences between the rough and smooth endoplasmic reticulum (ER) is explained by the structural differences between them?
Rough ER can synthesize and package proteins for export, and smooth ER cannot.
Students conducted a controlled experiment to investigate whether sawdust provides enough nutrients to support plant growth. The students separated ten nearly identical sunflower seedlings into two groups. They grew the seedlings in the first group in potting soil and the seedlings in the second group in sawdust composed mostly of cellulose. After twenty days, the students recorded observations about the seedlings in each group. The students' observations are presented in the table. The observed differences between the groups most likely resulted from differences in the ability of the seedlings to produce which of the following monomers?
Sawdust will not provide sufficient amounts of nitrogen and phosphorus, resulting in the seedlings having a reduced ability to produce both of the monomers shown (amino acids and nucleotides).
The sequences for two short fragments of DNA are shown above. Which of the following is one way in which these two segments would differ?
Segment 1 would become denatured at a lower temperature than would segment 2 because A-T base pairs have two hydrogen bonds whereas G-C base pairs have three.
Most cells that have become transformed into cancer cells have which of the following characteristics when compared to normal, healthy cells?
Shorter cell cycle
Cell communication is critical for the function of both unicellular and multicellular eukaryotes. Which of the following is likely true of cell signaling?
Similar cell signaling pathways in diverse eukaryotes are evidence of conserved evolutionary processes.
A student analyzed a viral genome and found that the genome had the following nucleotide composition. • 28% adenine • 20% thymine • 35% cytosine • 17% guanine Which of the following best describes the structure of the viral genome?
Single-stranded DNA
A student claims that the Y chromosome contains the sex-determining region gene, known as the SRY gene, which causes male fetuses to develop testes. Which of the following provides correct information about cell signaling that supports the claim?
The SRY gene produces a protein that binds to specific regions of DNA in certain tissues, which affects the development of these tissues.
The figure shows a model of the exchange of matter between the organisms that live together in an aquarium. The model includes matter exchange between plants, fish, and bacteria. The bacteria are represented as rod-shaped organisms living in the gravel at the bottom of the aquarium. Which of the following statements best describes how molecules released by the fish become nutrients for the plants?
The ammonia molecules released by the fish are converted by the bacteria to nitrates, which are used by the plants to make proteins and nucleic acids.
Figure 1. Amount of DNA per cell during different stages of the cell cycle, relative to the beginning of the G1 stage Which of the following best describes how the amount of DNA in the cell changes during M phase?
The amount of DNADNA is halved as the cell divides into two daughter cells.
Which of the following best describes a structural difference between DNA and RNA?
The backbone of DNA contains deoxyribose, whereas the backbone of RNA contains ribose
The carbohydrates glucose, galactose, and fructose have the same chemical formula (C6H12O6)(C6H12O6) but different structural formulas, as represented in the figure. Which of the following statements about glucose, galactose, and fructose is most likely true
The carbohydrates have different properties because they have different arrangements of carbon, hydrogen, and oxygen atoms.
A researcher designs an experiment to investigate the effect of environmental temperature on the function of an enzyme. For each trial included in the experiment, the researcher will add the enzyme and its substrate to an aqueous buffer solution and then measure the amount of product formed over 20 minutes. Which of the following must remain the same for all trials of this experiment?
The initial concentration of the substrate
Figure 1. A model showing a cell engulfing a smaller cell Which of the following provides evidence to best support the researchers' claim?
The organelle has a double membrane.
Figure 1. The results of an experiment using aquatic plant cells Which of the following statements best explains the observations represented in Figure 1 ?
There was a net movement of water out of the cell suspended in the sugar solution and a net movement of water into the cell suspended in the distilled water.
Which of the following best describes the function of the coenzymes NAD+ and FAD in eukaryoticcellular respiration?
They accept electrons during oxidation-reduction reactions.
Which of the following best describes the structures of carbohydrates?
They occur as monomers, chains of monomers, and branched structures.
A researcher claims that some bacteria contain factors that influence the function of a particular enzyme but other bacteria do not. To test the claim experimentally, the researcher will grow two different bacterial strains in separate liquid cultures and isolate the contents of the cells in each culture. The researcher will add different combinations of cellular contents, substrate, and enzyme to test tubes containing a buffer solution adjusted to the optimal pH of the enzyme and then measure the rate of product formation. The design of the researcher's experiment is presented in Table 1. Table 1. An experiment for investigating the influence of bacterial factors on enzyme function Which of the following statements best justifies the inclusion of test tubes 3 and 7 in the experiment?
They will show whether the isolated cellular contents have enzymatic activity.
The synthesis of protein or carbohydrate polymers always produces which of the following as a byproduct?
Water
Which statement best describes the effect on water transport across the cell membrane if the aquaporin in the figure ceases to function?
Water molecules will still be able to move across the cell membrane but at a slower rate.
Which of the following scientific questions is most relevant to the model represented in the figure above?
Which molecular substance is actively transported across the plasma membrane?
know hydrolysis
break down with H2O
Site of modification and packaging of proteins and lipids prior to export from the cell
c, golgi apparatus
A feature of organic compounds NOT found in inorganic compounds is the presence of
carbon atoms covalently bonded to each other
A common laboratory investigation involves putting a solution of starch and glucose into a dialysis bag and suspending the bag in a beaker of water, as shown in the figure below. The investigation is aimed at understanding how molecular size affects movement through a membrane. Which of the following best represents the amount of starch, water, and glucose in the dialysis bag over the course of the investigation?
cross over starch, water increase, glucose decrease
According to the chemiosmotic theory (chemiosmotic coupling), the energy required to move protons from the mitochondrial matrix to the intermembrane space against a concentration gradient comes most directly from
electrons flowing along the electron transportchain
A pathogenic bacterium has been engulfed by a phagocytic cell as part of the nonspecific (innate) immune response. Which of the following illustrations best represents the response?
enter, meet up w/ lysosome, attack
A student placed 20 tobacco seeds of the same species on moist paper towels in each of two petri dishes. Dish A was wrapped completely in an opaque cover to exclude all light. Dish B was not wrapped. The dishes were placed equidistant from a light source set to a cycle of 14 hours of light and 10 hours of dark. All other conditions were the same for both dishes. The dishes were examined after 7 days, and the opaque cover was permanently removed from dish A. Both dishes were returned to the light and examined again at 14 days. The following data were obtained. According to the results of this experiment, germination of tobacco seeds during the first week is
increased by exposure to light
Which of the following is most directly responsible for water's unique properties?
it forms hydrogen bonds
a mismatched dna strand will create what daughter strands
one normal and one mutant
A human cell in prophase of mitosis can be distinguished from a human cell in prophase I of meiosis by the presence of
paired homologous chromosomes in the meiotic cell
A prokaryotic cell has which of the following?
plasma membrane
Carbohydrate-synthesizing reactions of photosynthesis directly require
products of the light reactions
During respiration, most ATP is formed as a direct result of the net movement of
protons down a concentration gradient
Directions: This group of questions consists of five lettered headings followed by a list of phrases or sentences. For each phrase or sentence, select the one heading to which it is most closely related. Each heading may be used once, more than once, or not at all. (A) Glysolysis(B) Krebs cycle (citric acid cycle)(C) Calvin cycle (light-independent reactions of photosynthesis)(D) Light-dependent reactions of photosynthesis(E) Chemiosmosis Process in which sugar is oxidized to pyruvic acid
A
Gelatin is a protein that is derived from collagen which is found in the bones, skin, and connective tissue of animals. To investigate the ability of various enzymes to digest gelatin, a group of students set up an assay involving camera film. Camera film contains gelatin and appears black when exposed to light but turns clear as the gelatin gets broken down. The students incubated pieces of exposed camera film in test tubes, each containing one of three different enzyme solutions (trypsin, lipase, or amylase) as indicated in Figure 1. The students recorded the time it took for the enzymes to digest the gelatin in each test tube, turning the film from black to clear. Figure 1. Diagram of experimental setup. Which of the following would be the most appropriate control for this experiment?
A test tube containing a piece of exposed camera film submerged in water
Damaged tissue releases chemicals that activate platelets and stimulate the formation of blood clots. Which of the following predictions about the activity of platelets best describes a positive feedback mechanism?
Activated platelets release chemicals that activate more platelets.
Students investigated the effect of light on the carbon cycle in aquatic ecosystems by performing the controlled experiment summarized below. The students placed equal amounts of water (pH 7.0) from a large aquarium in glass beakers. The students transferred aquatic plants from the aquarium to several of the beakers, and then they placed equal numbers of the beakers in the light or the dark (Figure 1: groups I and II. Similarly, the students transferred goldfish from the same aquarium to other beakers, and then they placed equal numbers of those beakers in the light or dark (Figure 1: groups III and IV. Finally, the students placed an equal number of beakers containing water only in the light or dark (Figure 1: groups V and VI After exposing the samples to light or dark for one hour, the students recorded the pH of the water in each beaker. Carbon dioxide dissolved in water will lower the pH of an aqueous solution. In the experiment, the students used changes in pH to monitor changes in the amount of carbon dioxide in the water. For each treatment group, the students calculated the mean pH and standard error, as documented in the table below. Which of the following graphs is the most appropriate representation of the experimental results documented in the table?
Bar graph, mean pH v. Treatment group
Butterflies of the genus Colias live in the Rocky Mountains, where they experience a wide range of temperatures. Different variants of a particular glycolytic enzyme in the flight muscles are optimally active at different temperatures. Within the same population, some individual butterflies fly most effectively at 29°C , while others fly most effectively at 40°C. Still others can be equally active at both temperatures. Which of the following claims is most consistent with the observed butterfly behavior?
Butterflies that express two variants of the enzyme are active over a greater range of temperature.
Directions: This group of questions consists of five lettered headings followed by a list of phrases or sentences. For each phrase or sentence, select the one heading to which it is most closely related. Each heading may be used once, more than once, or not at all. (A) Glysolysis(B) Krebs cycle (citric acid cycle)(C) Calvin cycle (light-independent reactions of photosynthesis)(D) Light-dependent reactions of photosynthesis(E) Chemiosmosis Process in which carbon from CO2 is incorporated into organic molecules
C
Figure 1. Number of chromosomes in a human cell at different stages of cell division Which of the following presents a correct interpretation of the changes in chromosome number depicted in Figure 1 ?
Chromosomes enter metaphase containing two chromatids attached by a centromere. During anaphase, the chromatids are separated, each becoming a chromosome. Cytokinesis distributes the chromosomes into two separate cells.
Alcohol dehydrogenase (ADH) is an enzyme that aids in the decomposition of ethyl alcohol (C2H5OH) into nontoxic substances. Methyl alcohol acts as a competitive inhibitor of ethyl alcohol by competing for the same active site on ADH. When attached to ADH, methyl alcohol is converted to formaldehyde, which is toxic in the body. Which of the following statements best predicts the effect of increasing the concentration of substrate (ethyl alcohol), while keeping the concentration of the inhibitor (methyl alcohol) constant?
Competitive inhibition will decrease because the proportion of the active sites occupied by substrate will increase.
Researchers investigating the regulation of neurotransmitter release from presynaptic neurons proposed a model (Figure 1) in which CDK5, a protein expressed in axon terminals, inhibits the movement of synaptic vesicles to the presynaptic membrane. To test their model, the researchers used a modified version of green fluorescent protein (GFP*)r. In slightly alkaline conditions, GFP*exhibits a bright green fluorescence. In acidic conditions, GFP* exhibits no fluorescence. Using standard techniques, the gene encoding GFP* is easily introduced into living cells. By engineering the expression of GFP* in laboratory-cultured nerve cells, the researchers found that a bright green fluorescence was exhibited only when a presynaptic neuron was given a certain stimulus. Based on the model, which of the following best explains how regulation of neurotransmitter release might increase the range of responses to a stimulus in the nervous system?
Different neurons in the same neural network can release different amounts of neurotransmitter.
The diagram below shows energy changes in a specific chemical reaction with and without the addition of an enzyme to the reaction. Which of the following questions can best be answered by the diagram?
Does the addition of an enzyme reduce the activation energy required for a reaction?
The chemical reaction for photosynthesis is 6CO2 + 12H2O + light energy → C6H12O6 + 6O2 + 6H2O If the input water is labeled with a radioactive isotope of oxygen, 18O, then the oxygen gas released as the reaction proceeds is also labeled with 18O. Which of the following is the most likely explanation?
During the light reactions of photosynthesis, water is split, removing electrons and protons, and oxygen gas is released.
Figure 1 is a diagram of water molecules at the air-water interface at the surface of a pond. Figure 1. Based on Figure 1, which of the following best describes how the properties of water at an air-water interface enable an insect to walk on the water's surface?
Hydrogen bonds between molecules at the surface of the water provide surface tension, which allows the water surface to deform but not break under the insect.
Which of the following is responsible for the cohesive property of water?
Hydrogen bonds between the oxygen atom of one water molecule and a hydrogen atom of another water molecule
For the following questions: Graphs I-IV depict the effect of pH on the activity of four different hydrolytic enzymes. Enzymes with their highest activity at an alkaline (basic) pH are represented by which of the following graphs?
II only
Figure 1. A simplified model of the epinephrine signaling pathway in muscle cells Based on Figure 1, which of the following statements best describes the epinephrine signaling pathway?
In involves enzymes activating other enzymes.
Researchers performed an experiment to determine the effect of certain genetic mutations on mitosis in tropical fruit fly embryos. They determined the percentage of cells in each of four phases of mitosis as shown in Figure 1. Figure 1. Percent of cells in phases of mitosis Which of the following patterns is shown by the data?
In mutant 3 cells, more time is spent in prophase/prometaphase than in the later stages of mitosis.
Cortisol is a hormone produced in response to stress, including starvation, in humans. Which of the following is most likely an immediate effect of a starvation-induced increase in cortisol secretion?
Increased mobilization of fatty acids from fat cells
Of the following, which additional investigation can be used to determine when the cells are in an isotonic solution?
Increasing the salinity of the environment a little at a time until the ATP usage reaches a minimum
Which statement best explains why correct protein folding is critical in the transmembrane protein shown above?
Interactions of the hydrophobic and hydrophilic amino acids help to anchor the protein in the membrane.
Which of the following is true of mitosis?
It maintains the same chromosome number in the daughter cells as in the parent cell.
Which of the following statements best justifies the inclusion of test tube V as a control in the experiment? (Amylase is a protein that catalyzes the conversion of starch to simple sugars. Amylase activity in an aqueous solution can be measured by using iodine as a starch indicator. A solution containing iodine and starch will have a dark-blue color, whereas a solution containing iodine but no starch will have a light-brown color. The color change of an iodine solution from dark blue to light brown can be used to measure the rate at which starch is converted to simple sugars. A student designs an experiment to investigate the effect of environmental pH on amylase function. The design of the experiment is presented in Table 1.)
It will show the color change that occurs in the absence of enzyme activity.
Directions: This group of questions consists of five lettered headings followed by a list of phrases or sentences. For each phrase or sentence, select the one heading to which it is most closely related. Each heading may be used once, more than once, or not at all. This group of questions refers to molecules of the following substances. (A) Cytochrome(B) FADH2(C) NAD+(D) NADP+(E) Oxygen (O2) An intermediate electron acceptor for oxidations that occur in both glycolysis and in Krebs cycle reactions
NAD+
The manner in which several different ions and molecules move through a cell membrane is shown in the diagram above. For each ion or molecule, the relative concentration on each side of the membrane is indicated. Which of the following accurately describes one of the movements taking place?
Na+ transport out of the cell requires ATP hydrolysis.
A researcher examining a root tip observes a plant cell with condensed sister chromatids, kinetochores with attached microtubules, and individual chromosomes that are aligned at the equatorial plate of the cell. Which of the following best describes what the next process will be in the cell?
Paired chromatids will separate, and the new daughter chromosomes will move toward opposite poles of the cell.
Which of the following statements best describes how organisms such as rabbits obtain the carbon necessary for building biological molecules?
Rabbits eat plants and break down plant molecules to obtain carbon and other atoms that they rearrange into new carbon-containing molecules.
In flowering plants, plasmodesmata are narrow channels through cell walls that connect the cytoplasms of adjacent cells. An explanation of how plant cells communicate across cell walls will most likely refer to the diffusion through plasmodesmata of which of the following?
Small, water-soluble molecules
Which of the following statements best supports the claim that certain organelles within eukaryotic cells evolved from free-living prokaryotic cells?
Some organelles contain their own DNA that is more similar to prokaryotic DNA in structure and function than to the eukaryotic DNA found in the cell's nucleus.
Based on the model of eukaryotic cell cycle regulation shown in the figure, which of the following best describes the effect of a drug that blocks the production of the mitotic cyclin?
The cell would be prevented from entering mitosis, and the cell would stop dividing.
Intravenous solutions administered to patients are normally isotonic. Which of the following is most likely if an IV of distilled water is administered to a patient?
The cells that are exposed to hypotonic solutions will expand as water moves osmotically into the cells from the blood.
Researchers compared similar proteins from related organisms in different habitats. They found that the proteins from organisms living in harsh environments had a greater number of cysteine amino acids than did proteins from organisms not living in harsh environments. The structure of cysteine is shown. Bonds can form between the sulfur atom of different cysteine amino acids (S-SS-S bonds). Figure 1. Which of the following best describes the effect of a greater number of cysteine amino acids on the stability of the proteins?
The change leads to increased protein stability because of an increased number of S-SS-S bonds in the tertiary structure of the proteins
Paramecia are unicellular protists that have contractile vacuoles to remove excess intracellular water. In an experimental investigation, paramecia were placed in salt solutions of increasing osmolarity. The rate at which the contractile vacuole contracted to pump out excess water was determined and plotted against osmolarity of the solutions, as shown in the graph. Which of the following is the correct explanation for the data?
The contraction rate increases as the osmolarity decreases because the amount of water entering the paramecia by osmosis increases.
A team of biologists develop a new drug, and one team member hypothesizes that the drug is incapable of freely passing across the plasma membrane and requires the help of membrane proteins to enter cells. Alternatively, another biologist on the team hypothesizes that the drug can diffuse passively across the plasma membrane like O2 and CO2 can. Which of the following, if true about the drug, best supports the alternative hypothesis that the new drug will exhibit simple diffusion across plasma membranes?
The drug is a small nonpolar molecule.
A researcher proposes a model of an enzyme-catalyzed reaction in which a reactant is converted to a product. The model is based on the idea that the reactant passes through a transition state within the enzyme-substrate complex before the reactant is converted to the product. Which of the following statements best helps explain how the enzyme speeds up the reaction?
The enzyme's active site binds to and stabilizes the transition state, which decreases the activation energy of the reaction.
Peptide bond Figure 1 represents a common process that occurs in organisms. Figure 1. Structural formula for a common biological reaction Which of the following is an accurate description of the process shown in Figure 1 ?
The formation of a covalent peptide bond in a dehydration synthesis reaction
Figure 1. A simplified model of the glucocorticoid receptor signaling pathway Which of the following statements best predicts the effect of a mutation that results in a loss of the glucocorticoid receptor's ligand binding function?
The glucocorticoid receptor will remain associated with the accessory proteins.
A small protein is composed of 110 amino acids linked together in a chain. As shown in Figure 1, the first and last five amino acids in the chain are hydrophobic (have nonpolar and uncharged RR-groups), whereas the remaining 100 amino acids are hydrophilic (have charged or polar RR-groups). The nature of the RR-group determines if the amino acid is hydrophobic or hydrophilic. A mutation results in the production of a version of the small protein that is only 105 amino acids long, as shown in Figure 2. Five of the hydrophobic amino acids are missing from one end of the chain. Which of the following best depicts the tertiary structures of the two proteins in water? The diagrams in the options are not drawn to the same scale as those in Figure 1 and Figure 2.
The hydrophilic middle of the protein chain would be attracted to the water molecules, and the hydrophobic ends would be repelled. Hydrophobic portions of proteins in water tend to be found near the center of the tertiary structure, as far from the water as possible.
The model below shows the structure of a portion of a plasma membrane in an animal cell. Which statement best explains the orientation of the phospholipid molecules in this model?
The hydrophilic phosphate groups of the phospholipid molecules are attracted to the aqueous internal and external environments.
Nucleic acid fragment Which of the following characteristics of Figure 1 best shows that the fragment isRNA and not DNA?
The identity of each nitrogenous base
The figure above shows an organelle typically found in eukaryotic cells. Which of the following best describes the function of the double membrane system of this organelle?
The inner membrane has specialized proteins that create a hydrogen ion concentration gradient between the intermembrane space and the matrix.
Which of the following best describes how amino acids affect the tertiary structure of a protein?
The interactions of the different RR-groups with other RR-groups and with their environment determine the tertiary structure of the protein.
The figure shows a process by which a cell might absorb food from its surrounding environment and break it down for use as a source of energy and matter. The process involves lysosomes, which are membrane-bound organelles that contain hydrolytic enzymes. Activation of the hydrolytic enzymes requires an acidic pH, and lysosomes maintain an internal acidic pH by using ion pumps. Which of the following outcomes will most likely result from a loss of ion pump function in the cell's lysosomes?
The internal pH of the lysosomes will increase, which will prevent the activation of hydrolytic enzymes and interfere with the intracellular digestion of food.
Figure 1. Model of signal transduction cascade incorporating protein A DNA mutation changes the shape of the extracellular domain of transmembrane receptor protein A produced by the cell. Which of the following predictions is the most likely consequence of the mutation?
The molecule that normally binds to protein AA will no longer attach, deactivating the cellular response.
Figure 2. Blood glucose levels for an individual mouse over the duration of the experiment. Based on the data in Figure 2, which of the following best justifies the researchers' claim that hESC-β implants can functionally replace the mouse's naturally occurring β-cells?
The mouse with an hESC-β implant successfully regulated blood glucose levels after STZ treatment but not after the implant was removed.
Which of the following statements best justifies the claim that the conditions in at least one of the experiments could generate the molecular building blocks essential for life?
The nitrogen ( N2) gas and ammonia ( NH3) gas in experiment 1 could provide the elemental nitrogen required for the formation of amino acids.
Water and ammonia interact to form hydrogen bonds, as represented in the figure. Which statement best helps explain the formation of the hydrogen bond represented in the figure?
The nitrogen has a partial negative charge, and the hydrogen attached to the oxygen has a partial positive charge.
A human kidney filters about 200 liters of blood each day. Approximately two liters of liquid and nutrient waste are excreted as urine. The remaining fluid and dissolved substances are reabsorbed and continue to circulate throughout the body. Antidiuretic hormone (ADH) is secreted in response to reduced plasma volume. ADH targets the collecting ducts in the kidney, stimulating the insertion of aquaporins into their plasma membranes and an increased reabsorption of water. If ADH secretion is inhibited, which of the following would initially result?
The person would produce greater amounts of dilute urine
Which of the following statements best helps explain the reaction specificity of an enzyme?
The shape and charge of the substrates are compatible with the active site of the enzyme.
A sample of human blood was placed in a test tube containing a physiological saline solution (0.9% sodium chloride). This type of solution is often used intravenously to quickly rehydrate patients. A drop of the blood from the test tube was placed on a slide and red blood cells (RBCs) were observed under a microscope. Three possible outcomes are diagrammed below. Which of the following best predicts which diagrammed microscope view the laboratory worker would see and best explains why?
View 2 because the rate of water movement into the RBCs equals the rate of water movement out of the cells
A student formulated a hypothesis that water-soluble pollutants damage living organisms by increasing the permeability of cellular membranes. To test the hypothesis, the student investigated the effect of isopropanol and acetone on beet root cells. The vacuoles of beet root cells contain large amounts of betacyanin, a water-soluble pigment that is released into the extracellular environment as a result of increased membrane permeability. The student prepared identical samples of beet root tissue and incubated each sample for 15 minutes in the specific solution for that group. At the end of the incubation period, the student measured the absorbance of 460 nm light for each sample. A greater concentration of betacyanin in the solution surrounding the beet root cells results in a greater absorbance of 460 nm light. The results of the experiment are shown in the table above. Based on the data from the investigation, which of the following is the best scientific question about organisms living in water that is polluted with organic solvents?
Will organisms living in polluted environments exhibit detrimental effects from an increased permeability of their cellular membranes?
