Beckmann Ch. 41 quiz: Menopause

Alendronate is a member of which drug class?

Bisphosphonate

What is the expected rate of bone loss in perimenopausal women?

0.5% per year

A 54-year old woman with an LMP 3 years ago presents for an annual examination. She is concerned about her risk of hip fracture because of a strong family hx of fracture. Which of the following would you recommend as the most appropriate dietary therapy for this patient?

1200 mg calcium carbonate supplementation plus 10 ug vitamin D daily

What is the typical FSH level during perimenopause?

13-24 mlU/ml

Approximately how many oocytes does a woman have at the time of puberty?

400,000

What is the typical FSH level during a woman's prime reproductive years?

6-10 mlU/ml

Approximately what % of women in the US experience vasomotor symptoms (hot flashes) in the perimenopausal and menopausal period?

75%

Ovarian function ceases by 55 years of age in what % of women?

95%

What is the effect of decreasing estrogen on the sleep cycle?

? Latent phase lengthened, sleep period shortened

A 52-year old woman with an LMP 6 months ago presents for an annual examination. She is currently experiencing hot flashes and night sweats that are interfering with her life. Her most recent bone scan has shown some loss. Her mother had a hip fracture at age 60 years. She has smoked one pack per day of cigarettes for 40 years. Her sister and maternal aunt had breast cancer. Which of the following would you recommend as the most appropriate initial therapy for this patient?

Daily estrogen and progestin

Which of the following is a known risk of unopposed estrogen therapy?

Endometrial adenocarcinoma

Vaginal dryness associated with menopause is a function of a decrease in which hormone?

Estrogen

Which of the following is generally the first physical manifestation of decreasing ovarian funciton?

Hot flashes

A 48-year-old woman with her last menstrual period 2 weeks ago presents to your office complaining of irregular menses at 15-day to 45-day intervals for the past 6 months. PMHx and SHx are noncontributory. There is no hx of tobacco use. Her BMI is 28.3. A pelvic examination suggests several small fibroids. Which of the following would be the most efficacious initial therapy for this woman?

Low-dose OCP agent

St. John's wort may be helpful in managing which of the following associated with menopause?

Mild depression

In postmenopausal women, endometrial hyperplasia is most associated with which of the following factors?

Obesity

Partial deletion of the long arm of one X chromosome results in:

Premature ovarian failure

Which of the following is a contraindication to hormone therapy associated with menopausal symptoms?

Recent arterial thromboembolic disease

Which of the following is responsible for early menopause in the women with savage syndrome?

Resistance of ovarian follicles to FSH and LH

Cigarette smoking has what effect on the timing of menopause?

Smokers experience menopause earlier than nonsmokers

Which hormone is the major product of the postmenopausal ovary?

Testosterone

Which of the following has been shown to influence the age of menopause?

Tobacco use

A 52-year old woman with an LMP 6 months ago presents for an annual examination. She is currently experiencing vaginal dryness and dyspareunia. She has smoked one pack per day of cigarettes for 40 years. Her sister and maternal aunt had breast cancer. Which of the following would you recommend as the most appropriate initial therapy for this patient?

Topical estrogen therapy

A 52-year old woman with an LMP 2 months ago presents for an annual examination. She is currently asymptomatic, but her most recent bone scan has shown some loss. Her mother had a hip fracture at age 60. She has smoked one pack per day of cigarettes for 40 years. Her sister and maternal aunt had breast cancer. Which of the following would you recommend as the most appropriate therapy for this patient?

bisphosphonate

Administration of continuous unopposed estrogen can result in

endometrial hyperplasia

Decrease in the level of which of the following hormones is responsible for the vasomotor symptoms of menopause?

estrogen

Perimenopause is associated with a decrease in:

high-density lipoprotein

Bisphosphonates act to manage bone loss associated with menopause by:

inhibiting osteoclast bone resorption

Increasing free testosterone associated with menopause is directly mediated by a decrease in

sex hormone-binding globulin