Blood Bank Book Questions - Unit 2

What immunodominant sugar determines the specificity of H antigens? a. D-galactose b. L-fucose c. N-acetylgalactosamine d. L-glucose

b. L-fucose

Select the ABO phenotypes, in order from most frequent to least frequent, that occur in whites: a. A, B, O, AB b. O, A, B, AB c. B, A, AB, O d. AB, O, B, A

b. O, A, B, AB

A donor is tested with Rh antisera; given the following results, what is the most probable Rh genotype? Anti-D: + Anti-C: + Anti-E: 0 Anti-c: + Anti-e: + Rh control: 0 a. R1R1 b. R1r c. R0r d. R2r

b. R1r

What is the common form of antibodies produced upon exposure to Rh blood group system antigens? a. naturally occurring IgM b. immune IgG c. immune IgM d. naturally occuring IgG and IgM

b. immune IgG

The regulator gene RHAG: a. is inherited on chromosome 1 b. is responsible for the Rh(mod) phenotype c. must be inherited to express LW antigens d. is responsible for the D-deletion phenotype

b. is responsible for the Rh(mod) phenotype

Which of the following red cell genotypes would react negatively with anti-G? a. R0r b. rr c. R2r d. r'r

b. rr

Which ABO discrepancy is the best explanation for the results shown? Anti-A: 4+ Anti-B: 0 A1: 2+ B: 4+ a. an elderly patient b. subgroup of A c. deterioration of reagents d. hypogammaglobulinemia

b. subgroup of A

Anti-f was identified in a patient. Because commercial antisera are not available, what is the best course of action to locate compatible RBC units? a. crossmatch E-negative units b. contact the rare donor registry c. release O, D-negative units d. crossmatch c-negative units

d. crossmatch c-negative units

Which of the following situations may produce ABO discrepancies in the serum testing? a. newborn b. patient with hypogammaglobulinemia c. cold alloantibody d. all of the above

d. all of the above

How is the Rh genotype CDE/cDE written in Wiener notation? a. R0R1 b. RyR2 c. R2R1 d. RzR2

d. RzR2

What immunoglobulin class is primarily associated with ABO antibodies? a. IgA b. IgG c. IgE d. IgM

d. IgM

What is the name of the blood group system that was originally identified as the Rh blood group system? a. Kell b. Lutheran c. Lewis d. LW

d. LW

What immunodominant sugar confers B blood group specificity? a. D-galactose b. L-fucose c. N-acetylgalactosamine d. L-glucose

a. D-galactose

A donor tested D-negative using commercial anti-D reagent. The weak D test was positive. How should the RBC unit be labeled? a. D-positive b. D-negative c. D variant d. varies with blood bank policy

a. D-positive

Which offspring is NOT possible from a mother who is R2r and a father who is R1r? a. DcE/DcE b. DCe/DcE c. DcE/ce d. ce/ce

a. DcE/DcE

Which lectin agglutinates A1 red cells? a. Dolichos biflorus b. Ulex europaeus c. Dolichos europaeus d. Ulex biflorus

a. Dolichos biflorus

Which of the following genotypes is heterozygous for the C antigen? a. R1r b. R2R2 c. R1R1 d. r'r'

a. R1r

Which of the following genotypes could make anti-Ce (Rh7)? a. R2R2 b. R1R0 c. R1R2 d. r'r

a. R2R2

A patient's Rh phenotype was determined to be D+, c+, e+, C-, E-. The race of this donor is most likely: a. black b. white c. Asian d. Native American

a. black

In Rosenfield notation, the phenotype of a donor may be written as Rh: 1, -2, -3, 4, 5. What is the correct phenotype in Fisher-Race (CDE) notation? a. cDe b. CcDe c. CcDE d. CDEe

a. cDe

What ABO phenotypes would be compatible if the group O patient required a transfusion of fresh frozen plasma? a. group AB, O, A, or B b. group O or B c. group AB or O d. only group O

a. group AB, O, A, or B

What is the ABO interpretation? Anti-A: 0 Anti-B: 0 A1: 4+ B: 4+ a. group O b. group A c. group B d. group AB

a. group O

Which of the following phenotypes would react with anti-f? a. rr b. R1R1 c. R2R2 d. R1R2

a. rr

What test is needed to determine weak D antigen status? a. the IAT b. the DAT c. anti-Du typing sera d. anti-D antisera with a LISS potentiator

a. the IAT

What statement is true relative to the results of a weak D test performed on a patient with a positive direct antiglobulin test? a. accurate as long as the check cells were positive b. unreliable because of immunoglobulins already on the cell c. reliable if a high-albumin anti-D was used d. false-negative because of antibody neutralization

b. unreliable because of immunoglobulins already on the cell

What is the likelihood that two heterozygous D-positive parents will have a D-negative child? a. less than 1% b. not possible c. 25% d. 75%

c. 25%

What soluble antigen forms are detectable in saliva based on the following genotype: AB, HH, SeSe? a. none (nonsecretor) b. only H c. A, B, and H d. A and B

c. A, B, and H

Which of the following statements is true about ABO antibody production? a. ABO antibodies are present in newborns b. ABO titers remain at constant levels throughout life c. ABO antibodies are stimulated by bacteria and other environmental factors d. All of the statements are true

c. ABO antibodies are stimulated by bacteria and other environmental factors

An antibody to the E antigen was identified in a patient who received multiple transfusions. What is the most likely phenotype of the patient's red cells? a. R1R1 b. R2R2 c. R1r d. r'r'

c. R1r

What gene controls the presence of soluble H substance in saliva? a. H b. A c. Se d. B

c. Se

What ABO antibody is expected in this patient serum based on the following information? Anti-A: 0 Anti-B: 0 a. anti-B b. anti-A c. anti-A and anti-B d. none

c. anti-A and anti-B

According to Landsteiner's rule, if a patient has no ABO antibodies after serum testing, what ABO antigens are present on the patient's red cells? a. A b. B c. both A and B d. none

c. both A and B

Given the following ABO typing results, what is the potential conclusion for these results? Anti-A: 4+ Anti-B: 4+ A1: 1+ B: 0 a. expected results for a group O individual b. expected results for a group AB individual c. discrepant results; patient has A antigen on red cells with anti-A in serum d. discrepant results; patient has B antigen on red cells with no anti-B in serum

c. discrepant results; patient has A antigen on red cells with anti-A in serum

Which result is discrepant if the red cell typing shown in the following chart is correct? Anti-A: 0 Anti-B: 4+ A1: 0 B: 0 a. negative reaction with group B cells b. positive reaction with anti-B c. negative reaction with group A1 cells d. no discrepancies

c. negative reaction with group A1 cells

What term describes using known sources of reagent antisera (known antibodies) to detect ABO antigens on a patient's red cells? a. Rh typing b. reverse grouping c. direct antiglobulin test d. forward grouping

d. forward grouping

Anti-D was detected in the serum of a D-positive person. What is a possible explanation? a. the antibody b. compound antibody was formed c. regulator gene failure d. missing antigen epitope

d. missing antigen epitope

An individual has the genotype AO, hh. What antigens would be present on the red cells of this individual? a. A only b. A and H c. A and O d. none of the above

d. none of the above

What ABO phenotypes would be compatible if the patient requires a transfusion of RBCs for group O? a. group AB, O, A, or B b. group O or B c. group AB or O d. only group O

d. only group O

Which of the following is associated with the Rh(null) phenotype? a. elevated D antigen expression b. increased LW antigen expression c. the Bombay phenotype d. red cell membrane abnormalities

d. red cell membrane abnormalities

What are the gene products of the A and B genes? a. glycolipds b. glycoproteins c. oligosaccharides d. transferase enzymes

d. transferase enzymes