BRM's (Biological Response Modifiers) used for RA
serious infection TB MS
Contraindicated in which patients?
Rituximab
Drug has a BLACK BOX WARNING about serious infections
Tocilizumab
May cause decrease in WBCs, platelets and liver dysfunction
Anakinra
May cause severe decrease in WBC count
Abatacept
Monitor for dyspnea, wheezing, Flushing, and itching
Rituximab
Observe for infusion reaction as for entanercept
Infliximab
Only BRM that shouldn't be refrigerated
Infliximab
Patient is to report chest pain or difficulty breathing during infusion, and monitor bp
Abatacept
Patient is to report cough, dizziness and sore throat; not to receive love vaccines while taking this drug
Anakinra
Patient is to report respiratory symptoms such as cough and fever; malignancies can result
Golimumab
Patient is to report s/s of infection, including fever and malaise; should avoid live vaccines while taking this drug
Crowds Live vaccines Ppl with infections
What patients should avoid when taking BRMs?
Golimumab
Adverse effects include HTN, GI distress and infection
Etanercept (Enbrel) Infliximab Adalimunab Anakinra
After administration, monitor site for reaction