cAMP pathway

What happens after G-alpha-GTP activates Adenylyl Cyclase (AC)

AC converts ATP into cAMP

What happens after the degradation of cAMP?

ATP is regenerated from pyrophosphate (PPi) and AMP

What happens after the formation of G-alpha-GDP

G-alpha-GDP re-associates with beta-gamma

What occurs after the receptor returns to its normal configuration?

G-alpha-GTP activates Adenylyl Cyclase (AC)

What happens after formation of cAMP

G-alpha-GTP becomes G-alpha-GDP

What happens after stimulant bound receptor experiences conformational change?

GTP to GDP, and separates G alpha from the beta gamma subunits

What happens after G-alpha-GDP re-associates with beta gamma?

Hydrolysis of ATP by Adenylate Cyclase (AC)

What happens after dephosphorylation of GTP cause separation of G alpha and beta gamma subunit

Receptor returns to its normal conformation as G alpha GTP disassociates from beta gamma

What is the first step of cAMP pathway?

The stimulant binds to the receptor, which causes a physical conformational change

What happens after the hydrolysis of ATP

cAMP activates PKA (4 cAMP binds to two regulatory subunits)

What happens after the activation of PKA

cAMP is degraded to AMP by a phosphodiesterase (PDE)