CH 15 Bowman 255
1, 14, 21
FAD mutations on chromosomes ___
30 and 60
FAD occurs between ages ___ and ___
memory, reasoning, language, and eventually physical function
alzheimers characterized by gradual deterioration of ___
neurofibrillary tangles and amyloid plaques
alzheimers disease can possibly cause by formation of ___
ACH (Acetyl choline
alzheimers disease can possibly cause by reduction in ___
dementia
alzheimers is a type of ____
respite
alzheimers patiences need ____ care
34.85
among 100,00 people there are about ____ centenarians
chronic disease
prolonged elevation of stress-related hormones associated with risk of ___
120
rebecca lanier lived to
60
1 in 11 men over ____ years get alzheimers
60
1 in 6 women over ____years get alzheimers
alzheimer
2xs as many women experience ______compared to men
progeria
Hutchinson - Gilford syndrome is a form of ___
true
T/F: coconut oil aids alzheimers
43rd
US is ranked ___ overall for life expectancy
elevated cortisol
___ ____ levels relate to telomere shorting and aging
cholinesterase
___ inhibitors help aid alzheimers
marital
___ instablility in adulthood would lead to shorter life expectancy
rember
___ targets and dissolves "tangles"
nimean-pick disease type C
___Stems from a genetic mutation that causes cholesterol to build up in liver, spleen, and brain
poor sleep
_____ has been implicated in alzheimers disease and has been linked to increased amyloid plaques
perceptual
a person with nimean-pick disease type C they lose the reasoning and _____ abilities
shorter; divide
as cells divide telomeres become ___ and eventually cells can no longer ___
volume and weight
as the brain ages the brain loses ___ and ___
10 or 12
by age ____ all the external features of old-age are manifested
physically and emotionally draining
caring for a family member with alzheimers can be ____
cell division
cause of progeria is unknown but studies show that only few generations of ____ before they start reproducing
50-70
cells can divide ___ times
90
centenarians in japan make up ___% women
50-51
chad, angola, mozambique have the lowest life expectancy of ___
shortening
chronic stress advances telomer ____
decline in functioning of brain and central nervous system
decline in speed of processing is likely due to
hippocampus
depression may cause changes in the ____
fat and sugars
diets high in ___ and ___ increase the risk of developing alzheimers
yes
does swittzerland and sweden have high life expectancy?
brain
eating a healthy diet, getting good sleep and keeping your heart healthy are all factors of helping ____ health
brain
exercise can improve ____ power
oxygen
exercise improves supply of ___ throughout the body
air conditioner
hormonal stress theory can be compared to as the _____ analogy
memory, language, emotional problems
in stage 4 of alzheimers youll see a dramatic change in _____
cognitive
maintaining a high level of ___activity appears to be another somewhat protective factor of alzheimers
80
more than ___% of wives outlive their husbands
pediatric
nimean-pick disease type C described to be like a ____ version of alzheimers disease (many die before 10)
motor
nimean-pick disease type C has slow loss of ____ skills
dopamine
parkinsons disease is triggered by degeneration of neurons that produce ___ in the brain
cancer and arthritis
resulting damage on cellular structures and DNA can lead to range of disorders such as
shrink
some brain areas ___ more than others
cardiovascular disease, diet, lack of exercise
some possible links are associated with alzheimers?
40s and 70s
some studies report dendritic growth between the ___ and the __
declines
speed of processing information ____ in late adulthood
walk, sit up, chew and shallow food
stage 5 of alzheimers a person can no longer __
the long goodbye
stage 5 of alzheimers is called
self
stage 5 of alzheimers there seems to be very little left of the person's ____
japan
there are about 67,824 centenarians living in___
85
there is a possible 'life expectancy cross over' if a male makes it to ____ years he will out live female
physical coordination and intellectual performances
what 2 things are also affected with brain aging?
Growth failure during the first year of life, Narrow, shrunken or wrinkled face, Baldness, Loss of eyebrows and eyelashes, Short stature, Large head for size of face (macrocephaly)
what are some symptoms of progeria?
prevent the breakdown of acetylcholine, related to learning and memory
what does cholinesterase inhibitors do?
werners syndrome
what is adult progeria called?
neurotransmitter necessary for normal brain functioning
what is dopamine?
a chronic, progressive disease characterized by muscle tremors, slowing of movement, and partial facial paralysis
what is parkinsons disease?
A genetic disorder caused by spontaneous gene mutation - premature aging*
what is progeria?
services that provide temporary relief to caregivers
what is respite care?
mediterranean diet - tomatoes, fish, olive oil, red wine plant based diets
what kind of diet aids alzheimers?
aricept, exelon, antidepressants, anxiolytics, gama guard, namzeric
what kind of drugs aid alzheimers?
antioxidant vitamins (C, E) such as raisins, spinach and blueberries
what things aid alzheimers?
age 4
when does Hutchinson - Gilford syndrome start?
early adult hood and follows the same rapid progression
when does werners syndrome start?
jean louis calment (122)
who has the longest documented and verified life in modern times?
deposits of proteins accumulating in blood vessels
what is amyloid plaques?
irisin
what is an exercise hormone?
10
___% of cases of FAD
leaner
____ adults live longer and healthier lives
oxidative
____ damage impairs mitochondrial functioning
nigerians
____ have the highest frequency of ApoE4 yet they have some of the lowest rates of alzheimers
caloric
____ restriction works to increase life span of animals but human connection is not specifically known
energy
affected mitochondria become so inefficient that not enough ___ is generated to meet cellular needs
females - 81.2; males - 76.4
average year for females life expectancy? average year for males?
blacks
by biological factors white outlive ____ across species
chronically ill children
caregivers of ___ ___ ____ have shorter life expectancy than normal
aerobic
exercise especially ___ combined with strength training is good for brain health
diabetes, cholesterol, HBP and stroke which are all factors that can damage the brain
exercise reduces risk of _____
5
females outlive males by about __ years
DNA
free radicals damage ___ and other cellular structures
shot of whiskey
grace jones indicated that a _____ a day aids her life and living longer
multidimensionality and multi-directionality
health and exercise may be influencing factors of _____
thinking, memory and socialization
hearing and vision loss are linked to problems with ___
lower BP and stress reduction exercises
in order to keep your heart healthy you must ___ BP and do ___ reduction exercises
health conditions, medical care etc.
international difference in life expectancy due to ___
3
longevity has increased __ months per year since 1840
terman termites
low life expectancy among ___ ____
animal fat (cholesterol)
nigerians have a diet low in ____
nuns
only moderate intellectual declines among a group of ___ involved in teaching and intellectual pursuits
65
people with a late onset of alzheimers generally start to experience symptoms older than ___years
care for themselves and recognize familiar surroundings and people
people with dementia lose the ability to
pre senile
people younger than 65 have about 5% _____ dementia
longevity
positive emotions can increase __
cholesterol
pre senile dementia has a more definitive connection with _____
genetic
pre senile dementia have a strong ___ component (ApoE gene)
socially and intellectually
staying ___ and ___ active can help brain health
prefrontal
the ___ cortex is one of those areas most likely to experience shrinkage with age
5-10%
the brain loses ___ to ___% of its weight by the age of 90
sensory and motor
there is an increasingly physical, ___ and ___ declines with age in late adulthood
70
there is no dendritic growth after age ____
hormonal
theres question whether or not to link ____ levels
DNA sequence that cap chromosomes
what are telomeres?
iceland
what country has the highest life expectancy for men?
japan
what country has the highest life expectancy for women?
alzheimers
what disease is a progressive irreversible brain disorder?
cholesterol
what is ApoE4 associated with?
family related alzheimers disease
what is FAD?
hippocampus
what is affected when amyloid plaques forms?
person who is 100 years or older
what is centenarian?
85 years
what is japan, sigapore and macau life expectancy?
90 years
what is monacos/french mediterranean life expectancy?
twisted fibers that build up in neurons
what is neurofibrillary tangles?
parental divorced would lead to a shorter life expectancy
what is terman termites?
78.6 now closer to 79 years
what is the US average life expectancy?
senescence
what is the biological aging; genetically influenced declines in the functioning of organs and systems
as we age cells become less capable of diving
what is the cellular clock theory?
87
what is the desired age to live up to?
people age because as cells metabolize energy, the by-products include unstable typically molecules known as free radicals
what is the free radical theory?
dementia
what is the global term for any neurological disorder in which the primary symptoms involve a deterioration of brain and mental functioning
aging in the body's hormonal system can lower resistance to stress and increase likelihood of disease
what is the hormonal stress theory?
85
what is the life expectancy of okanowa japan?
life span
what is the maximum number of years an individual can live called?
120-125 years
what is the maximum number of years an individual can live?
aging due to decay of mitochondria
what is the mitochondria theory?
life expectancy
what is the number of years that the average person will probably live called?
age 100
what is the projected life expectancy of 2084?
decrease in branching of dendrites damage to myelin sheath and shrinking of neurons and to minor extent neuron loss
what is the reason for brain loss of weight?
hippocampus and olfactory bulb
where would neurogenesis appear?
