Ch. 9 Success Virology (50 q.)

9. Which of the following viruses is predomi- nantly associated with respiratory disease and epidemics of keratoconjunctivitis? A. Adenovirus B. Molluscum contagiosum virus C. Norwalkvirus D. Rotavirus

A. Adenovirus

27. Rhabdovirus is most noted for causing infections of the A. Central nervous system B. Gastrointestinal tract C. Lower respiratory tract D. Upper respiratory tract

A. Central nervous system

39. An 8-week-old infant was admitted to the hospital with symptoms of low birth weight, jaundice, and neurologic defects.Intranuclear inclusions were found in epithelial cells from the urine. The most likely diagnosis in this case would be infection by A. Cytomegalovirus B. Epstein-Barrvirus C. Herpes simplex virus D. Rubellavirus

A. Cytomegalovirus

7. The molecular receptor of the virus causing acquired immune deficiency syndrome is A.CD4 B. CDS C. Fc receptor D. Complement receptor

A.CD4

3. Characteristics of this DNA hepatitis virus include infections spread by contaminated body fluids, 50- to 180-day incubation period, and chronic infections. A. HAV B. HBV C. HCV D. HEV

B. HBV

48. Poliovirus is a member of the family A. Flaviviridae B. Paramyxoviridae C. Picornaviridae D. Reoviridae

C. Picornaviridae

1. The retrovirus responsible for causing acquired immune deficiency syndrome is a member of the family A. Orthomyxoviridae B. Paramyxoviridae C. Retroviridae D. Flaviviridae

C. Retroviridae

38. The togavims known to produce fetal defects is A. Influenza B. Rotavirus C. Rubella D. Varicella

C. Rubella

14. The viral disease shingles, which causes extreme tenderness along the dorsal nerve roots and a vesicular eruption, has the same etiologic agent as A. Rubeola B. Vaccinia C. Varicella D. Variola

C. Varicella

20. Arboviruses A. Only infect humans B. Often cause hepatitis C. Typically infect lymphocytes D. Are transmitted by arthropods

D. Are transmitted by arthropods

13. Which of the following is not a general characteristic of a virus? A. Obligate intracellular parasite B. Does not produce A TP C. Genome is surrounded by a protein coat D. Can self-replicate in the appropriate host cell

D. Can self-replicate in the appropriate host cell

40. The most common cause of cervical cancer is A. Cytomegalovirus B. Enterovirus C. Molluscum contagiosum D. Papillomavirus

D. Papillomavirus

50. Which of the following diseases is not associated with herpes simplex virus? A. Cold sores B. Encephalitis C. Genital herpes D. Thrush

D. Thrush

28. Jaundice is a common clinical symptom of which of the following viral diseases? A. Hepatitis A B. Infectious mononucleosis C. Rabies D. Varicella

A. Hepatitis A

4. Which of the following has been declared eradicated by the World Health Organization? A. Smallpox B. Human T cell lymphotropic virus C. Hepatitis G virus D. Eastern equine encephalitis

A. Smallpox

43. The use of cell cultures has enabled virologists to isolate and identify many clinically important viruses. However, because some viruses cannot be grown in cell cultures, these agents are best diagnosed by serologic testing. Such an agent is A. Cytomegalovirus B. Hepatitis C virus C. Herpes simplex virus 2 D. Respiratory syncytialvirus

B. Hepatitis C virus

2. The appearance of Koplik spots in the oral mucosa of patients is characteristic of infection with what viral agent? A. Hepatitis B. Measles C. Rabies D. Smallpox

B. Measles

41. Select the statement that is correct concerning the influenza A viruses. A. Humans are the only animal hosts for influenza A viruses. B. Pandemics are characteristically produced by influenza A. C. The incidence of infection peaks in the summer months. D. They are DNA viruses.

B. Pandemics are characteristically produced by influenza A.

21. Mumps is characterized by an infection of the A. Central nervous system B. Parotid glands C. Pancreas D. Thymus

B. Parotid glands

35. RNA-dependent DNA polymerase is also called A. Gyrase B. Neuraminidase C. Reverse transcriptase D. Transaminase

C. Reverse transcriptase

25. Human herpesviruses 6 and 7 are associated with a childhood disease called A. Chickenpox B. Measles C. Roseola D. Zoster

C. Roseola

6. Kaposi sarcoma is associated with infection by A. Adenovirus B. Cytomegalovirus C. Hepatitis E vims D. Human herpes virus 8

D. Human herpes virus 8

18. Molluscum contagiosum virus is a member of the A. Adenoviruses B. Herpesviruses C. Papovaviruses D. Poxviruses

D. Poxviruses

17. Negri bodies may be found in brain tissue of humans or animals infected with A. Adenovirus B. Filovirus C. Measles virus D. Rabies virus

D. Rabies virus

15. The etiologic agents of many common colds are RNA viruses that grow better at 33°C than at 37°C. These viruses are A. Adenoviruses B. Orthomyxoviruses C. Paramyxoviruses D. Rhinoviruses

D. Rhinoviruses

47. Although there have been no natural cases of this serious disease in about 30 years, which of the following is considered a potential bioterrorism disease A. Dengue B. Ebola hemorrhagic fever C. Shingles D. Smallpox

D. Smallpox

19. A clinical specimen is received in viral transport medium for viral isolation. The specimen cannot be processed for 72 hours. At what temperature should it be stored? A. -80°C B. -20°C C. 4°C D. 22°C

A. -80°C

23. Enteroviruses are most often associated with A. Acute nonspecific febrile syndrome B. Bronchitis and pneumonia C. Lower respiratory tract infections D. Upper respiratory tract infections

A. Acute nonspecific febrile syndrome

12. Which of the following is caused by a herpes virus? A. Cold sores B. Hemorrhagic fever C. Polio D. Rabies

A. Cold sores

24. The "core window" refers to the time A. During hepatitis B virus infection when anti-HBc IgM is the only serologic marker B. During hepatitis B virus infection when HBc is the only serologic marker C. During hepatitis A virus infection when HAc is the only serologic marker D. During hepatitis C virus infection when the virus is latent

A. During hepatitis B virus infection when anti-HBc IgM is the only serologic marker

33. Characteristic cytopathic effect associated with respiratory syncytial virus is A. Giant multinucleated cells B. Basophilic intranuclear inclusions C. Eosinophilic cytoplasmic inclusions D. Shrunken cells with multilobed nuclei

A. Giant multinucleated cells

22. Which of the following hepatitis viruses is typically transmitted by the fecal-oral pathway? A. HAV B. HBV C. HCV D. HGV

A. HAV

5. Rotavirus is the most common etiologic agent of A. Acute nonbacterial encephalitis in children B. Acute nonbacterial gastroenteritis in infants and young children C. Chronic nonbacterial pharyngitis in children and young adults D. Chronic nonbacterial retinitis in children

B. Acute nonbacterial gastroenteritis in infants and young children

16. Influenza A virus undergoes recombina- tion events that produce new strains; this is referred to as A. Antigenic drift B. Antigenic shift C. Reactivation D. Viral latency

B. Antigenic shift

11. The Sabin polio vaccine uses which of the following? A. Formalin-inactivated viruses B. Attenuated viruses C. Recombinant viral antigens D. DNA

B. Attenuated viruses

37. The tubular cells of the human kidney shed which of the following viruses for prolonged periods? A. Adenovirus B. Cytomegalovirus C. Epstein-Barr virus D. Rubellavirus

B. Cytomegalovirus

31. The virus that causes hepatitis B is characterized as a A. Defective DNA virus requiring delta virus to complete its replication cycle B. DNA virus utilizing reverse transcrip- tase C. Nonenveloped DNA virus D. Single-stranded RNA virus

B. DNA virus utilizing reverse transcriptase

29. An 18-year-old male presents to his family physician complaining of sore throat and fatigue. The patient is found to have a fever and swollen cervical lymph nodes. A complete blood count and differential reveal lymphocytosis and many reactive (atypical) lymphocytes. The physician should suspect an infection caused by A. Adenoviruses B. Epstein-Barr virus C. Parainfluenza virus D. Varicella-zostervirus

B. Epstein-Barr virus

45. Which of the following is not a step involved in virus replication? A. Attachment B. Mitosis C. Penetration D. Release

B. Mitosis

26. A baby was admitted to the hospital in February for dehydration due to severe diarrhea. Cultures for bacterial pathogens revealed normal fecal flora at 24 hours. Which of the following additional tests would be most appropriate given the case history? A. Heterophile antibody test B. Rotavirus antigen assay of stool specimen C. McCoy cell inoculation for cytomegalovirus (CMV) D. Urine microscopic analysis for presence of CMV cellular inclusion bodies

B. Rotavirus antigen assay of stool specimen

32. Hepatitis C virus infections A. Are commonly diagnosed during the acute stage B. Are uncommon in the U.S. C. Are most often acquired by contact with blood D. Seldom results in chronic infection

C. Are most often acquired by contact with blood

34. The virus associated with warts is A. Flavivirus B. Morbillivirus C. Mumps virus D. Papillomavirus

D. Papillomavirus

42. An example of a virus associated with latent infections is A. Influenza B. Rotavirus C. Rubella D. Varicella-zoster

D. Varicella-zoster

30. The poliovirus, an RNA virus, is a(n) A. Adenovirus B. Coxsackievirus C. Enterovirus D. Rhinovirus

C. Enterovirus

49. Which of the following has not been successfully used to detect viruses in clinical specimens? A. Cytopathiceffect B. Enzyme-linked immunosorbent assay C. Growth on selective agar media D. Immunofluorescence

C. Growth on selective agar media

8. The type of cell culture that best supports the growth of cytomegalovirus is A. HeLa cells B. HEp-2cells C. Human fibroblast cells D. Primary monkey kidney (PMK) cells

C. Human fibroblast cells

44. Which of the following is associated with the rubella virus? A.It is a DNA virus. B. It is a member of the same taxonomic family as measles virus. C. It is known to produce defects in fetuses during the early stages of pregnancy. D. It is transmitted by an arthropod vector.

C. It is known to produce defects in fetuses during the early stages of pregnancy.

46. Which of the following opportunistic diseases is not closely associated with acquired immune deficiency syndrome? A. Cryptococcosis B. Cryptosporidiosis C. Malaria D. Mycobacteriosis

C. Malaria

36. Coxsackie viruses are associated with A. Gastrointestinal disease B. Hepatitis C. Myocarditis D. The common cold

C. Myocarditis

10. A 25-year-oldpatientpresentedwith multiple vesicles around the mouth. Material from the lesions was obtained by needle aspiration and inoculated to MRC-5 cells. After 1 day, the cytopathic effect included foci of "ballooned" and lysed cells. These observations suggest infection with A. Adenovirus B. Cytomegalovirus C. Epstein-Barrvirus D. Herpes simplex virus

D. Herpes simplex virus