Chapter 11

What type of leukemia primarily affects children?

ALL

A 5 year old patients parents report loss of appetite and fatigue in their child. The parents also state that the child refuses to walk due to back pain. The child's diagnosis is

Acute Lymphoid Leukemia (ALL0

Lymphoid lineage

B cells, T cells, and natural killer (NK) cells

A diagnostic laboratory finding in myeloma is

Bence Jones proteins in the urine

Clinical presentation of high granulocytes count

Chronic Myeloid Leukemia

Characterized by malignant granulocytes that carry the Philadelphia Chromosome

Chronic Myeloid Leukemia (CML)

Which form of leukemia demonstrated the presence of the Philadelphia chromosome?

Chronic Myeloma Leukemia (CML)

Symptom of CML that stands out front the other

Sweats

Petechiae, easy bruising, bleeding gums, occult hematuria, and retinal hemorrhages are all clinical manifestations of

Thrombocytopenia

Myeloid lineage

red cells, platelets, monocytes, and granulocytes

Circulating tumors that are disseminated from the beginning of the disease process; primarily involve blood and bone marrow

Leukemias

Clinical manifestations of AML

Malignant immature WBC, large segmented nucleus, fine chromatin, and increased infection susceptibility

A 58 year old woman is seen in the clinic for reports of severe back pain. Her chest X-ray demonstrated generalized bone demineralization and compression fracture. Blood studies demonstrate elevated calcium levels. The most likely diagnosis is

Myeloma

What are clinical findings presented in ALL

Pain in long bones, infection, fever, and bruising

Common infection sites of AML

skin, GI, GU, and respiratory tract