genetics and genomics

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conditional alleles

alleles in which the phenotypic expression depends on the environmental conditions

Polymorphism

The coexistence of two or more distinct forms in the same population.

At the permissive temperature, the organism lives normally. When the organism is shifted to the non-permissive temperature, the effect of inactivating the gene can be studied. which of the three types of mutations below is most likely to lead to a conditional allele - single nucleotide substitution - single nucleotide addition - single nucleotide deletion

- single nucleotide substitution

Finding co-inheritance of a SNP variant and a disease tells scientists that ____________________. (a) everybody who carries this SNP will get the disease. (b) sequences within the SNP cause the disease. (c) a gene important for causing the disease is linked to the SNP. (d) SNPs on other chromosomes will not be co-inherited with the disease

(c) a gene important for causing the disease is linked to the SNP.

which of the following statements about genome wide association studies is FALSE a. GWAPs use SNPs to compare populations of people with disease and people without disease to look for SNPs more likely to be present in the diseased b. GWAS can be used even if more than one gene can cause the disease of interest c. sometimes GWAS will identify SNPs that are associated with a disease, but these SNPs do not affect the gene product of the the gene that causes the disease d. studies using GWAS only examine SNPs that occur very rarely in the population, as those SNPs are most likely to cause disease

d. studies using GWAS only examine SNPs that occur very rarely in the population, as those SNPs are most likely to cause disease

The phenotype of an organism reflects all of the alleles carried by that individual, true or false

false!


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