Lecture 6: Aholt Sexually Transmitted Diseases

the reticulate body stage of chlamydiae does what?

active metabolism

gonorrhea is normally _______ in women

asymptomatic

what is the treatment for syphilis?

benzathine penicillin

what two conditions are associated with tertiary syphilis?

cardiovascular disease neurosyphilis

C. trachomatis causes what STD?

chlamydiae

Lymphogranuloma granuloma are associated with what STD?

chlamydiae

lymphogranuloma venereum is associated with what STD?

chlamydiae

what STD increases the risk of HIV acquisition x5?

chlamydiae

what STD is the most common cause of cervicitis in women?

chlamydiae

what STD is the most common cause of urethritis in men?

chlamydiae

what is the most common STD in the US and UK?

chlamydiae

12 year old patient presents to dental office. Patient is deaf and has been diagnosed with symmetric hydrarthorisis. Upon oral examination you notice the anterior teeth have a screwdriver shaped appearance and the 12 year molars take on a mulberry appearance. What is the diagnosis?

congenital syphilis

Hutchinson teeth are considered to be pathognomonic of:

congenital syphilis

Mulberry molars are considered to be pathognomonic of:

congenital syphilis

Saddle-nose deformities of the nasal cartilage are due to untreated:

congenital syphilis

mother gives birth to infant that is suffering from rhinitis and has cutaneous rashes. The infant has developed osteochondritis, hepatosplenomegaly and adenopathy. The mother explained that she was initially carrying twins but the second infant was stillborn. What is the diagnosis for the child?

congenital syphilis

if you treat primary syphilis with penicillin, what is the prognosis?

cured

if you treat secondary syphilis with penicillin, what is the prognosis?

cured

what diagnostic method can you use to diagnose a suspected syphilis ulceration?

darkfield microscopy

how is syphilis contracted?

direct contact with infected human

women that contract gonorrhea are at risk of what pregnancy complication?

ectopic pregnancy

t/f: it is not possible to get a repeated gonorrhea infection

false

Gonococcal Ophthalmia Neonatorum is acquired in infants born while their mother has what STD?

gonorrhea

Neisseria gonorrhoeae causes what STD?

gonorrhea

cause of pelvic inflammatory disease in women?

gonorrhea

what STD can cause Epididymitis?

gonorrhea

what STD is the cause of 1/3rd all urethritis?

gonorrhea

what is the 2nd most common cause of soar throat?

gonorrhea

what type of STD is this?

gonorrhea

if you treat tertiary syphilis with penicillin, what is the prognosis?

gummas resolved, other damage remains

patients with primary syphilis are _____ contagious

highly

patients with secondary syphilis are _____ contagious

highly

a patient that has a history of secondary syphilis presents asymptomatic, absent of any clinical disease or symptoms, however the serological test comes back positive for syphilis. What is the diagnosis?

latent syphilis

chlamydiae can cause what two diseases?

lymphogranuloma venereum urethritis

cases of primary and secondary syphilis are higher in what patient population?

men that have sex with men

Neisseria gonorrhoeae infect what type of cells?

mucus-secreting epithelial cells

patients with tertiary syphilis are _____ contagious

not

how is chlamydiae diagnosed?

nucleic acid amplification tests (NAAT)

in Neisseria gonorrhoeae ,these proteins bind receptors on immune cells and prevent the generation of an immune response

opa protein

patient presents with a large chancer ulcer on the glans penis. Patient denies pain. Patient has regional adenopathy in the groin. Patient's serological test comes back negative for syphilis. What is the diagnosis?

primary syphilis

syphilis infection that is localized to an area is most likely what type of syphilis?

primary syphilis

antibiotics against chlamydiae are only affective against what stage?

reticular body stage

latent syphilis occurs between what stages?

secondary and tertiary syphilis

patient presents to your office complaining of flu-like symptoms. Patient exhibits malaise, headache, sore throat, arthralgias, low fever, and adenopathy. Patient exhibits nickle/dime lesions on the chin and one on the buccal mucosa. Patient also exhibits palmar and plantar rashes. Serological test comes back positive, high bacteremia for syphilis. What is the diagnosis?

secondary syphilis

syphilis infection that becomes systemic is most likely what type of syphilis?

secondary syphilis

gonorrhea is normally _______ in men

symptomatic

Treponema pallidum causes what STD?

syphilis

patient presents to your office complaining of symptoms consistent with vasculitis. Patient has a long history of syphilis. Patient has gummas on multiple surfaces of skin and MRI scan had detected presence of gummas in the brain. What is the diagnosis?

tertiary syphilis

syphilis infection that causes long term inflammation of the CNS is most likely what type of syphilis?

tertiary syphilis

the elementary body stage of chlamydiae does what?

transit form that goes from one cell to another

t/f: HPV is preventable via vaccine

true

for women that are pregnant and contract syphilis, before what week should they get treatment in order to prevent lesions of congenital syphilis?

16

the contraction of syphilis is also commonly associated with the contraction of _____

HIV

this STD can infect the respiratory tract and cause death by suffocation:

HPV

this STD causes cutaneous and anogenital warts, cervical cancer:

HPV

which HVP causes cancer?

HPV 16 and 18

which HVP causes genital warts?

HPV 6 and 11

what is the treatment for gonorrhea?

Ceftriaxone 500mg

gonorrhea is caused by what bacterium?

Neisseria gonorrhoeae

Chlamydiae is caused by what bacteria?

C. trachomatis

Strict intracellular bacteria, genome small; cannot generate ATP; has no oxidative enzymes, flavoproteins or cytochromes; can make own proteins:

C. trachomatis

Neisseria gonorrhoeae need what nutrient to survive?

CO2

what is the treatment for chlamydiae?

Doxycycline or azithromycin

Gram-negative diplococcus on Gram stain which infects mucus-secreting epithelial cells. Evades host immune system through alteration of cell surface and pili:

Neisseria gonorrhoeae

syphilis is cause by what bacterium?

Treponema pallidum