Opioid receptors

Where do Mu opioid receptors work?

Are responsible for analgesia in the spinal and supraspinal areas specifically the substantia gelatinosa also in the posterior horn of the spinal

Mu1- MUSE

Miosis Urinary retention Supraspinal analgesia Europhia

What opioids are agonists on all three receptors

Morphine Meperidine Fentanyl Sufentanil Alfentanil Remifentanil

Which opioid causes euphoria?

Mu1

synthetics opioids act on what receptor

Mu1 and Mu2

Endorphins and morphine are associated with which receptor

Mu1 and mu2

Which Opioid receptor causes marked constipation?

Mu2

What are opioid antagonist on all three receptors

Naltrexone Naloxone Nalmefene

What opioids Are antagonists on the Mu receptor

Naltrexone Naloxone Nalmefene

MU receptors have a different sub time. At this time the significance is not well understood. True or false

True

Opioid receptors either act to inhibit Adenylyl cyclase and cyclic adenosine monophosphate cAMP production or they directly interact with different ion channels in the membrane.

True

Once activated, opioid receptors can cause

attenuation of the excitability of neurons and or reduces the release of pronociceptive neuropeptides:

How many opioid receptors are there?

3. Mu, Kappa and Delta

What percentage of transmembrane G protein coupled receptors show homologies for opioid genes?

40-70%

Mu2- Brains

Bradycardia Respiratory depression Itching Nausea and vomiting and constipation Spain also analgesia

What opioids or partial agonist on the Kappa receptor

Butorphanol Nalbuphine

What receptors are agonists on the Delta receptor

Butorphanol Nalbuphine

Enkaphalins and urinary retention is associated with which opioid receptor?

Delta

Physical dependence and respiratory depression is seen in which opioid receptor?

Delta

What are the names of naturally occurring opioid agonist

Endorphins Enkephalins Dynorphins

All opioid receptors are ________.

G-protein coupled

Where can opioid receptors modulate?

In the pre-and post synaptic membrane, calcium channels by suppressing calcium influx

What occurs when G Protein receptors opens after being activated by an opioid receptor

It results in an increase in potassium entering the cell which prevents neural excitability and Prevents action potential

dynorphins and diureses is associated with which receptor

Kappa Agonists

Does kappa receptors cause respiratory depression

Kappa receptors are not associated with respiratory depression but they do cause G.I. motility and dysphoria

Delta- Raps

Respiratory depression Addictive Poorly understood and constiPation Supraspinal

What does mu receptors activation cause?

Respiratory depression, decreased GI motility

Opioids classifications by Chemical class

See table 11.1 page 129

Kappa- same shit different day man!

Spinal and supraspinal analgesia Sedation Dysphoria and diuresis Dependence Miosis

Where are opioid receptors expressed?

They are expressed in the central and peripheral neurons, Adrenal pituitary immune and ectodermal cells

Where are the kappa receptors located?

They are located in the same area as the MU receptors

What are delta receptors responsible for

They are responsible for supraspinal and spinal analgesia. Their activation causes modulation of hormone a neurotransmitter release.