Pharmaceutics Exam 2 - Poll Everywhere + Group Presentation Questions

Which of the following is NOT a common side effect for Focalin XR? A. Trouble sleeping B. Anxiety C. Polyuria D. Upset stomach

C

Which of the following is NOT a correct recommendation for administration of Depakote Sprinkle capsules: a. Swallow the capsule whole b. Open the capsule and sprinkle entire contents onto soft food c. Chew capsules completely d. All of the above are correct recommendations

C

Which of the following is NOT a dose strength for Nitrostat? a. 0.3 mg b. 0.4 mg c. 0.5 mg d. 0.6 mg

C

Which of these dosage strengths is/are are available for Prevacid Solutab? a. 15 mg b. 30 mg c. 45 mg d. Both B and C e. Both A and B

E

When bound to the receptor Oxycontin acts as an a. Antagonist b. Inverse agonist c. Agonist d. Competitive inhibitor

C

Acetylcysteine maintains or restores________levels to protect the liver. A. Cysteine B. Glutathione C. Glucuronyltransferase D. NAPQI

B

Concerta contains Polyethylene Glycol, which serves as a: A) Diluent B) Lubricant C) Plasticizer D) Colorant

B

What is the mechanism of action for Verapamil? A) Beta Blocker B) Alpha Blocker C) Calcium Channel Blocker D) ACE Inhibitor

C

As pH decreases, phenergan becomes more stable. A.True B.False

A

For each of the tablet processing problems listed below, select the most likely reason for the condition. Picking A) Excessive moisture in the granulation B) Entrapment of air C) Tablet friability D) Degraded drug E) Tablet hardness

A

For each of the tablet processing problems listed below, select the most likely reason for the condition: Sticking A) Excessive moisture in the granulation B) Entrapment of air C) Tablet friability D) Degraded drug E) Tablet hardness

A

How many minutes is the usual times allowed for the disintegration of most uncoated tablets? A) 30 B) 60 C) 90 D) 120 E) 180

A

In Depakote Sprinkle capsules, silica gel acts as a(n)________ a. Agent to increase flow b. Coloring agent c. Binder d. Lubricating agent

A

MATCH the lettered formulation design that best describes the mechanism of release from each of the following sustained-release drug delivery systems: Drug particles are microencapsulated and a mixture of the particles is formulated into the dosage form. A) Encapsulated dissolution B) Ion-exchange C) Matrix diffusion D) Matrix dissolution E) Osmotic pump

A

Sandimmune inhibits immunocompetent lymphocytes in which phase of the cell cyle? A. G1 Phase B. S Phase C. G2 Phase D. M Phase

A

What is the purpose of including Polysorbate 20, a surfactant, in the Spritam tablet? a. Surfactants are used to increase the solubility and stability of a drug in solution/suspension. b. They are fillers and serve no purpose. c. Polysorbate 20 is the active pharmaceutical ingredient in Spritam tablets. d. Polysorbate 20 is used as flavoring to mask the bad taste of Spritam tablets.

A

For each of the tablet processing problems listed below, select the most likely reason for the condition. Capping A) Excessive moisture in the granulation B) Entrapment of air C) Tablet friability D) Degraded drug E) Tablet hardness

B

If the FDA requires unit expression in SI units for product specifications, what is the correct viscosity and surface tension of the HPMC (5cp, 47 dyn/cm)? a) 5 Pa.s, 47 mNm-1 b) 5 mPa.s, 47 mNm-1 c) 50 mPa.s, 470 mNm-1 d) 500 mPa.s, 4,700 mNm-1 e) 5.000 mPa.s, 47,000 mNm-1

B

If the density displacement factor for zinc oxide is 4.44, and the suppository mold holds 2.0 g of cocoa butter, how much cocoa butter would be required to prepare 12 of the suppositories (300 mg each) for this prescription? A) ZnO: 0.36 grams + Cocoa Butter: 23.19 grams. B) ZnO: 3.6 grams + Cocoa Butter: 23.19 grams. C) ZnO: 36 grams + Cocoa Butter: 23.19 grams. D) ZnO: 36 grams + Cocoa Butter: 231.9 grams.

B

MATCH the lettered formulation design that best describes the mechanism of release from each of the following sustained-release drug delivery systems: Drug is bound to a resin and released due to changes in pH A) Encapsulated dissolution B) Ion-exchange C) Matrix diffusion D) Matrix dissolution E) Osmotic pump

B

What is the active pharmaceutical ingredient in Vagifem? A. Magnesium stearate B. Estradiol C. Polyethylene glycol D. Lactose

B

What polymer is the ER release tablet made out of (Oxycontin)? a. Hydrophilic polymers b. Hydrophobic polymers c. It does not have polymers d. Hydroxypropylmethylcellulose

B

What purpose does Barium Sulfate have in the ParaGard T 380A IUD? A. Changes uterine environment to inhibit sperm survival. B. Aids in the viewing of the T 380A on X-ray scans. C. Composes T-frame of device and aids in detection/removal of the device. D. All of the Above E. None of the Above

B

When phenergan is exposed to prolonged air and moisture, what color does it turn? A.Brown B. Blue C. Orange D. Red

B

Which of the following is INCORRECT about sublingual tablets? a. Sublingual tablets are rapidly absorbed b. Sublingual tablets have 100% bioavailability c. Sublingual tablets are highly volatile and should be kept in their original container d. Sublingual tablets are fast acting

B

Which of the following is an acceptable route of administration for miconazole? a. Oral b. Buccal c. IV d. IM

B

Which of the following statements is UNTRUE? a. Prevacid can be used to treat GERD or stomach ulcer b. ODT tablets can be chewed or swallowed whole c. Prevacid inhibits proton-pump in the stomach to reduce acid secretion d. Lansoprazole is the generic name of Prevacid e. Lactose in an inactive filler ingredient

B

A pharmacist receives a prescription for 15 mg piroxicam capsules, qty. 48. A #1 capsule filled with piroxicam weighs 245 mg; a capsule filled with lactose weighs 180 mg. How much piroxicam and lactose are required for the prescription? Prepare sufficient powder for 50 capsules (2 extra). A. 15 mg piroxicam + 165 mg lactose B. 750 mg piroxicam + 9.00 g lactose C. 750 mg piroxicam + 8.45g lactose D. 15 mg piroxicam + 230 mg lactose E. None of the above

C

If the API of 125 mg tablet decays by zero-order kinetics with a reaction rate constant kinetic of 0.5 mg per hour, what is the amount of intact drug remaining after 3 days (72 hours)? A. 0.89 mg B. 8.9 mg C. 89 mg D. 890 mg

C

MATCH the lettered formulation design that best describes the mechanism of release from each of the following sustained-release drug delivery systems: Drug is compressed into tablets with an insoluble polymer A) Encapsulated dissolution B) Ion-exchange C) Matrix diffusion D) Matrix dissolution E) Osmotic pump

C

The rectal route of administration of drugs may be preferred over the oral route for some systemic-acting because: A. the drug does not have to be absorbed B. absorption is predictable and complete C. a portion of the absorbed drug does not pass through the liver before entering the systemic circulation D. inert binders, diluents, and excipients cannot interfere with absorption E. the dissolution process is avoided

C

What is a disadvantage of 3D printed Spritam? a. Spritam is a highly porous tablet b. Spritam can be given to pediatrics and the elderly c. The cost of Spritam d. No dosage adjustment is necessary if patient is hepatically impaired

C

At what temperature should Verapamil be stored? A) wet, cool area B) Refrigerated C) High heat D) Room Temperature

D

Concerta is supplied in which of the following strengths? A) 16mg B) 35mg C) 40mg D) 54mg

D

Considering this "secret" formula and procedure (1 tab = 500 mg), the amount of Acetaminophen (in kg) required to produce 1 million tylenol tablets is: A) 0.5 kg B) 5 kg C) 50 kg D) 500 kg E) 500,000 kg

D

For each of the tablet processing problems listed below, select the most likely reason for the condition. Mottling A) Excessive moisture in the granulation B) Entrapment of air C) Tablet friability D) Degraded drug E) Tablet hardness

D

How does copper enhance contraceptive efficacy? A. Interferes with sperm transport B. Interferes with fertilization of an egg C. Prevents Implantation D. All of the Above E. None of the Above

D

MATCH the lettered formulation design that best describes the mechanism of release from each of the following sustained-release drug delivery systems: Drug is compressed into tablets with a slowly soluble polymer A) Encapsulated dissolution B) Ion-exchange C) Matrix diffusion D) Matrix dissolution E) Osmotic pump

D

Miconazole inhibits which enzyme for its mechanism of action? a. CYP3A4 b. Alcohol Dehydrogenase c. Phospholipase C d. P450 14-alpha demethylase

D

Sandimmune soft gelatin capsules are available in which of the following strength(s)? A. 25mg B. 50mg C. 100mg D. Both A and C

D

Some key methods for the formulation of acetylcysteine include all of the following EXCEPT: A. Fluid bed granulation B. Direct Compression C. Wet granulation D. Dry granulation

D

What dosage form(s) does ALBENZA® come in? a. Tablets b. Chewable Tablets c. Oral solution d. Both A and B

D

Which of the following are recommended storage instructions for ALBENZA®? a. Store at room temperature b. Story in a cool, dry place away from light c. Keep out of the reach of children d. All of the above

D

Which of the following is the mechanism of action of Focalin XR? A. Calcium channel blocker B. Prostaglandin synthesis inhibitor C. Bacterial cell wall inhibitor D. norepinephrine-dopamine reuptake inhibitor

D

Advantages to the manufacturer for tablet film coating when compared to sugar coating include: I. shorter production times II. Less gross weight III. Lower incidence in coat chipping A. only I B. only II C. I and II D. II and III E. I, II, and III

E

How does the granulation process help produce better tablets? A. Improves flow and compression characteristics B. Reduces segregation C. Improves content uniformity D. Eliminates excessive amounts of fine particles E. All of the above

E

Most commercial vaginal suppositories use a base of: A) beewax B) cocoa butter C) glycerin D) glycerinated gelatin E) polyethylene glycols

E

Which of the following is NOT a benefit of Vagifem's formulation? A. Increased safety B. Avoids 1st pass metabolism C. Better patient adherence D. More consistent estrogen therapy E. All the above are benefits

E

You are asked to prepare 2 sets of twelve 1g suppositories, Set A and Set B. Set A requires 12 suppositories each containing 50mg of Drug X while Set B requires both 50mg of Drug X as well as 300mg of Drug Y in all twelve suppositories. Cocoa butter or Theobroma oil will be used for the base of the suppositories. B) How much does an individual suppository weigh in each set? Note: Displacement values of X and Y are 0.7 and 1.5, respectively. Hint: Make 15 suppositories to account for losses.

Individual suppo in Set A = 0.98g and in set B = 1.08g

You are asked to prepare 2 sets of twelve 1g suppositories, Set A and Set B. Set A requires 12 suppositories each containing 50mg of Drug X while Set B requires both 50mg of Drug X as well as 300mg of Drug Y in all twelve suppositories. Cocoa butter or Theobroma oil will be used for the base of the suppositories. A) What quantity of theobroma oil base is required in each set? Displacement values of X and Y are 0.7 and 1.5, respectively. Hint: Make 15 suppositories to account for losses.

Theobroma oil for set A = 13.9g, for set B =10.9g

Consider the basic tablet coating solution formula below, identify the function of each inactive ingredient? iron oxide yellow 0.6% w/w

opacifier/pigment or colorant

Consider the basic tablet coating solution formula below, identify the function of each inactive ingredient? titanium dioxide 3.1% w/w

opacifier/pigment, colorant

Consider the basic tablet coating solution formula below, identify the function of each inactive ingredient? PEG 0.8 %w/w

plasticizer/pore forming agent

Consider the basic tablet coating solution formula below, identify the function of each inactive ingredient? purified water 88 % w/w

polymer solvent and coating medium

Consider the basic tablet coating solution formula below, identify the function of each inactive ingredient? HPMC (5cp, 47 dyn/cm) 7.5 %w/w

water soluble polymer