pharmaceutics practice questions
What is the main role of the sugar spheres in Metadate CD capsules? A. API B. Filler C. Disintegrant D. Solution binder
B. Filler
What is the main polymeric component of Mirena (Levonorgestrel) IUD drug reservoir ? A. Polydimethysiloxane B. Polyethylene C. Polylactide D. Polyglycolide
A. Polydimethysiloxane
The shells of soft gelatin capsules may be made elastic or plastic by the addition of? A. Sorbitol B. Providone C. Polyethylene glycol D. HPMC
A. Sorbitol
Example of water insoluble poolymer for film coating include: I. Ehylcellulose II. Hydroxypropyl methylcellulose III. Cellulose acetate phthalate (CAP) DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer: A. if I only is correct B. if III only is correct C. if I and II are correct D. if II and III are correct E. if I, II, and III are correct
A. if I only is correct
Which of the following statements is NOT TRUE about modified-release drug products? Advising patients not chew on these products during administration They are commercially available in various solid dosage forms: ER tablets or Capsules Advising patients not to crush these products to maintain their physical integrity advising patients to drink a full glass of alcohol with these medications for better absorption Delayed release products are not bioequivalent to Extended release product for the same active ingredient.
Advising patients to drink a full glass of alcohol with these medications for better absorption
Dibasic calcium phosphate is mainly used as: A. lubricant B. Filler or Diluent C. Binder D. opacifier disintegrate
B. Filler or Diluent
Polyethylene Glycol 3350 and 8000 is used in Indomethacin (Indocin) suppositories as A. Active pharmaceutical ingredient B. Watersoluble base C. Melting base D. Levigating agent
B. Watersoluble base
Agents that might be used to enteric-coated tablets include: I. hydroxypropyl methylcellulose (HPMC) II. carboxymethylcellulose (CMC) III. cellulose acetate phtalate (CAP) DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer: A. if I only is correct B. if III only is correct C. if I and II are correct D. if II and III are correct E. if I, II, and III are correct
B. if III only is correct
A pharmacist receives a prescription for 15 mg piroxicam capsules, qty. 48. A #1 capsule filled with piroxicam weighs 245 mg; a capsule filled with lactose weighs 180 mg. How much piroxicam and lactose are required for the prescription? Prepare sufficient powder for 50 capsules (2 extra). A. 15 mg piroxicam + 165 mg lactose B. 750 mg piroxicam + 9.00 g lactose C. 750 mg piroxicam + 8.45g lactose D. 15 mg piroxicam + 230 mg lactose E. None of the above
C. 750 mg piroxicam + 8.45g lactose
Which of the following is used as plasticizer in Norvir soft capsules? A. Ritonavir B. Gelatin C. Polyoxyl 35 castor oil D. Titanium dioxide
C. Polyoxyl 35 castor oil
Which of the following describes proper storage techniques for Annovera vaginal ring? A. Store in direct sunlight B. Store in a freezer or refrigerator C. Store at room temperature D. Store very high temperatures
C. Store at room temperature
The rectal route of administration of drug may be preferred over the oral route for some systemic-action because A. the drug does not have to be absorbed B. absorption is predictable and complete C. a portion of the absorbed drug does not pass through the liver before entering the systemic circulation D. inert binders, diluents, and excipients cannot interfere with absorption E. the dissolution process is avoided.
C. a portion of the absorbed drug does not pass through the liver before entering the systemic circulation
High bloom strength gelatin is used in the manufacturing of? I. Soft gelatin capsules II. Hard gelatin capsules III. All tablets DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer: A. if I only is correct B. if III only is correct C. if I and II are correct D. if II and III are correct E. if I, II, and III are correct
C. if I and II are correct
What is a reason why rectal suppository formulation of an NSAID would be preferred for a patient? I. Rectal suppositories offer less therapeutic response than other formulations II. Patient is alert, aware, and able to swallow pills or capsules III. Patient is unconscious or experiencing nausea/vomiting DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer: A. if I only is correct B. if III only is correct C. if I and II are correct D. if II and III are correct E. if I, II, and III are correct
C. if I and II are correct
In which biopharmaceutics classification (BCS) can you find ritonavir (Low permeability with MW: 720 Da, Low solubility, water solubility: 1.1x10-4 mg/L at 25 degrees C)?
CLass4
The ingredient "yellow ferric oxide" act as __________________ in the formulation of Avigan tablets. Sweetener Plasticizer Colorant Surfactant
Colorant
The respective amount of zinc oxide and cocoa butter required to make these 12 suppositories is: A) ZnO: 0.36 grams Cocoa butter: 2.3 grams B) ZnO: 3.6 grams Cocoa butter: 2.3 grams C) ZnO: 0.36 grams Cocoa butter: 23 grams D) ZnO: 3.6 grams Cocoa butter: 23 grams E) ZnO: 3.6 grams Cocoa butter: 24 grams
D) ZnO: 3.6 grams Cocoa butter: 23 grams
What abuse deterrent formulation strategy was used in Morphine/Naltrexone (Embeda) Capsules A. Physico/Chemical effect B. Aversion/Unpleasant effect C. Prodrug/Implant effect D. Agonist/Antagonist
D. Agonist/Antagonist
How is Cleocin (Clindamycin) vaginal ovules formulated? A. Film coating method B. Wet granulation C. Hard gelatin capsule D. Fusion molding
D. Fusion molding
A satisfactory suppository base must meet all of the following criteria EXCEPT A. it should have a narrow melting range B. it should be nonirritating and nonsensitizing C. it should dissolve or disintegrate rapidly in the body cavity D. it should melt below 30ºC E. it should be inert
D. it should melt below 30ºC
what is ion exchange
Drug is bound to a resin and released due to changes in pH
what is matrix dissolution
Drug is compressed into tablets with a slowly soluble polymer
what is matrix diffusion
Drug is compressed into tablets with an insoluble polymer
what is osmotic pumping
Drug is compressed into tablets with semipermeable membrane and laser drilled hole through which drug is transported out by convective flow
Most commercial vaginal suppository use a base of: A) beewax B) cocoa butter C) glycerin D) glycerinated gelatin E) polyethylene glycol
E) polyethylene glycol
Which of the following capsules sizes has the largest capacity? A. 5 B. 4 C. 1 D. 0 E. 000
E. 000
Advantages to the manufacturer for tablet film coating when compared to sugar coating include: I. shorter production times II .less gross weight III. lower incidence in coat chipping DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer: A. if I only is correct B. if III only is correct C. if I and II are correct D. if II and III are correct E. if I, II, and III are correct
E. if I, II, and III are correct
Manufacturing variables that would likely affect the dissolution of a prednisone tablet in the body include: I. the amount and type of binder added II. the amount and type of disintegrant added III. the force of compression used during tableting DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer: A. if I only is correct B. if III only is correct C. if I and II are correct D. if II and III are correct E. if I, II, and III are correct
E. if I, II, and III are correct
Reasons for tablet coating include: I. Masking the bitter taste or bad smell III. Altering dissolution profiles (Controlled Release). III. Preventing unwanted contact of personnel with the drug and enhancing appearance and elegance DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer: A. if I only is correct B. if III only is correct C. if I and II are correct D. if II and III are correct E. if I, II, and III are correct
E. if I, II, and III are correct
The following steps involved in hard gelatin capsule shells production? I. Dipping II. Spinning III. Trimming DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer: A. if I only is correct B. if III only is correct C. if I and II are correct D. if II and III are correct E. if I, II, and III are correct
E. if I, II, and III are correct
Why is Metadate CD preferred over IR Formulations of Methylphenidate HCl? I. Higher adherence II. Once a day dosing instead of multiple times per day III. Less fluctuation of plasma concentration DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer: A. if I only is correct B. if III only is correct C. if I and II are correct D. if II and III are correct E. if I, II, and III are correct
E. if I, II, and III are correct
Which of the following is not a coating agent used for Rilutek (Riluzole)? Hypromellose Phthalate (HPMCP) Hypromellose (HPMC) Polyethylene Glycol 6000 Titanium Dioxide
Hypromellose Phthalate (HPMCP)
Arrange each form of Coumadin from least to most rapidly released in the gastrointestinal fluid. Granules, intact tablet, drug particles Intact tablet, drug particles, granules Drug particles, granules, intact tablet Intact tablet, granules, drug particles
Intact tablet, granules, drug particles
What is the purpose of Magnesium Stearate in the formulation of Purinethol tablet Disintegrant Filler Lubricant/antiadherent Active pharmaceutical ingredient
Lubricant/antiadherent
What is a disadvantage with using direct compression method? Occurrence of unblending due to variability in API and excipients size/density Fewer steps Direct compression excipients possess inherent disintegration properties (microcrystallinecellulose) Faster dissolution compared to wet granulation
Occurrence of unblending due to variability in API and excipients
Starch is the main disintegrant ingredient in the Decadron (dexamethasone) tablet formulation. The primary purpose of starch is to: Promote break down of particle aggregates Prevent sticking to die and punch Promote particle aggregation/cohesion in liquid state Facilitate flow of granules from hopper
Promote break down of particle aggregates
Which of the following is an advantage of the buccal formulation method of Fentora? Decreases transmucosal absorption Shorter onset of action Increases the amount of opioid being excreted Longer onset of action
Shorter onset of action
Hypromellose 2208 is an ingredient in all Glucophage (Metformin HCl) XR tablets. If this ingredient was removed from the medication what can we expect to change in the therapeutic effect or manufacturing process of Glucophage XR? No therapeutic or manufacturing effect will be noticed. Product would stick to machinery when being manufactured, causing an array of issues. Product may cake and will struggle to freely flow during manufacturing. The release of Glucophage XR when taken would be less controlled and result in a quicker release of the drug, removing the benefit of being an extended release tablet.
The release of Glucophage XR when taken would be less controlled and result in a quicker release of the drug, removing the benefit of being an extended release tablet.
The main reason for the common use of titanium dioxide in pharmaceutical formulations as effective opacifier (to make the system opaque) is: Its molar mass of 79.866 g/mol (Da) its high melting point of 1842 ºC its high refractive index of 2.7 its high boiling point of 2972 ºC the presence of the two oxygen atoms in its structural formula
its high refractive index of 2.7
What is the primary purpose of enteric coating of tablets? To release drug immediately in the mouth To delay drug release until the large intestine To avoid inactivation by gastric acidity To improve taste
To avoid inactivation by gastric acidity