Pharmacology 7e CH6 Exam Questions

Biologic response modifiers classified as DMARDs typically end in which of the following suffixes? a. -mab b. -prazole c. -pril d. -itis

a. -mab

Diazepam belongs to which controlled-substance schedule? a. C-IV b. C-II c. C-I d. C-III

a. C-IV

What drug is approved for Crohn's disease, RA, ankylosing spondylitis, plaque psoriasis, psoriatic arthritis, and ulcerative colitis? a. Humira b. Rheumatrex c. Enbrel d. Rinvoq

a. Humira

Acetyl-para-aminophenol (APAP) is the chemical name for which of the following drugs? a.acetaminophen b.ibuprofen c.aspirin d.naproxen

a. acetaminophen

Which of the following is a DMARD that is injected subcutaneously every other week and stored in the refrigerator? a. adalimumab b. azathioprine c. anakinra d. auranofin

a. adalimumab

NSAIDs do not interact with which of the following drug classes? a. antacids b. beta blockers c. digoxin d. warfarin

a. antacids

To which class of drugs does acetaminophen belong? a. antipyretic analgesics b. salicylates c. NSAIDs d. DMARDs

a. antipyretic analgesics

Which muscle relaxant has a topical cream dosage form? a. baclofen b. dantrolene c. chlorzoxazone d. carisoprodol

a. baclofen

Severe bone, joint, and muscle pain are associated with _____ use. a. bisphosphonate b. uricosuric c. SERMs d. muscle relaxant

a. bisphosphonate

Salicylate toxicity is characterized by all the following except a. hypothermia. b. mental confusion. c. acid-base disturbances. d. tinnitus.

a. hypothermia

NSAIDs carry boxed warnings for all the following adverse effects except a. increased risk of liver toxicity. b. increased risk of GI inflammation, ulceration, and bleeding. c. increased risk of serious heart attack. d. increased risk of serious stroke.

a. increased risk of liver toxicity.

How do salicylates reduce fever? a. increasing blood flow to skin and inhibiting PG synthesis b. increasing blood flow to muscles c. decreasing blood flow to muscles d. decreasing blood flow to skin and inhibiting ACh synthesis

a. increasing blood flow to skin and inhibiting PG synthesis.

Which NSAID is available as an IV solution and a suppository? a. indomethacin b. ketorolac c. diclofenac d. celecoxib

a. indomethacin

When injected, a 30 mg dose of which of the following NSAIDs is as effective as 12 mg of morphine in relieving pain? a. ketorolac b. aspirin c. acetaminophen d. tramadol

a. ketorolac

Which of the following drugs should only be used for a short term (less than five days)? a. ketorolac b. nabumetone c. meloxicam d. indomethacin

a. ketorolac

NSAIDs can cause damage to which of the following organs? a. kidneys b. liver c. skin d. heart

a. kidneys

The oral dose of acetylcysteine must be given as a _____ dose followed by a _____ dose. a. loading; maintenance b. maintenance; loading c. weak; strong d. strong; weak

a. loading; maintenance

Which of the following drugs may cause a skin rash or yellowish discoloration of skin, eyes, or both? a. metaxalone b. cyclobenzaprine c. diazepam d. methocarbamol

a. metaxalone

Which disorder or disease requires muscle relaxants? a. multiple sclerosis b. insomnia c. hypertension d. rheumatoid arthritis

a. multiple sclerosis

Which type of arthritis results in loss of cartilage elasticity and thickness and causes bone to wear and become deformed? a. osteoarthritis b. gout c. fibromyalgia d. psoriatic arthritis

a. osteoarthritis

Which of the following is an autoimmune disease? a. rheumatoid arthritis (RA) b. fibromyalgia c. psoriatic arthritis d .gout

a. rheumatoid arthritis (RA)

Rheumatoid arthritis is usually symmetric, which means that the a. same joints on both sides of the body are affected. b. joints on one side of the body are affected. c. only one system is affected at a time. d. big toes are affected first.

a. same joints on both sides of the body are affected.

A _____ muscle has involuntary contractions and occurs in the lining of the stomach, esophagus, uterus, and bladder. a. smooth b. cardiac c. GI d. skeletal

a. smooth

_____ is the antidote for an acetaminophen overdose. a. Atropine b. Acetylcysteine c. Naloxone d. Activated charcoal

b. Acetylcysteine

Patients who take _____ should be evaluated for latent TB prior to therapy and avoid live vaccines. a. muscle relaxants b. DMARDs c. COX-2 inhibitors d. NSAIDs

b. DMARDs

What warning label should appear on prescriptions for muscle relaxants? a. Take with fluids. b. May cause drowsiness. c. Refrigerate. d. Take with food or milk.

b. May cause drowsiness.

Acetaminophen is a good first-line medication for mild to moderate pain, but not for which of the following patients? a. a patient who has peptic ulcers b. a patient who is an alcoholic c. a patient who is at risk of Reye's syndrome d. a patient who takes an oral anticoagulant

b. a patient who is an alcoholic

Which patient population should not take a mixed analgesic? a. pregnant women b. alcoholics c. patients allergic to sulfa drugs d. teenagers

b. alcoholics

What nonnarcotic analgesic can be prescribed in the dosage form of gum? a. acetaminophen b. aspirin c. naproxen d. ibuprofen

b. aspirin

Which of the following drugs is a DMARD? a. acetaminophen b. azathioprine c. metaxalone d. nabumetone

b. azathioprine

Which of the following is used for the treatment of both acute and chronic gout? a. allopurinol b. colchicine c. sulfasalazine d. probenecid

b. colchicine

Which of the following muscle relaxants is contraindicated if used with or within 14 days of an MAOI or if the patient has hyperthyroidism, history of heart failure, heart blockage, and/or used during the acute recovery phase of heart attacks? a.diazepam b.cyclobenzaprine c.dantrolene d.carisoprodol

b. cyclobenzaprine

Which of the following muscle relaxants is a controlled substance? a. cyclobenzaprine b. diazepam c. baclofen d. chlorzoxazone

b. diazepam

Which of the following is contraindicated with sepsis? a. cyclophosphamide b. etanercept c. golimumab d .methotrexate

b. etanercept

What clinical effect or side effect of aspirin is also produced by acetaminophen (Tylenol)? a. diarrhea b. fever reduction c. liver damage d. inflammation reduction

b. fever reduction

Which of the following drugs is an NSAID? a. allopurinol b. ibuprofen c. cyclosporine d. diazepam

b. ibuprofen

What is the purpose of an antipyretic? a. reduce swelling b. reduce fever c. relax muscles d. relieve headache

b. reduce fever

The enteric-coated (EC) form of a medication a. should be taken longer than six months. b. should not be halved or crushed. c. protects the esophagus. d. may be halved or crushed.

b. should not be halved or crushed.

To treat rheumatoid arthritis, dugs must be administered that a. treat fever. b. turn off the immune system. c. treat pain. d. treat inflammation.

b. turn off the immune system.

_____ has a suppository dosage form. a. Acetylcysteine b. Choline magnesium trisalicylate c. Aspirin d. Salsalate

c. Aspirin

Why should aspirin not be given to children? a. It increases the risk of developing cancer. b. It may cause brain damage. c. It can lead to the development of Reye's syndrome in children who have been exposed to chicken pox or other viral infections. d. It can cause hearing loss.

c. It can lead to the development of Reye's syndrome in children who have been exposed to chicken pox or other viral infections.

_____ are a class of drugs that have analgesic, antipyretic, and anti-inflammatory effects. a. NSAIDs b. DMARDs c. Salicylates d. Muscle relaxants

c. Salicylates, a. NSAIDs

Which of the following drugs may enhance adverse reactions to corticosteroids? a. Robaxin b. Skelaxin c. Trilisate d. Zanaflex

c. Trilisate

Poisoning by which of the following drugs has become the most common cause of acute liver failure in the United States? a. ibuprofen b. aspirin c. acetaminophen d. naproxen

c. acetaminophen

Which of the following begins the process of muscle contraction? a. nicotinic b. calcium c. acetylcholine d. dopamine

c. acetylcholine

Which of the following is an approved medication to treat acetaminophen overdose? a. naloxone b. flumazenil c. acetylcysteine d. zoledronic acid

c. acetylcysteine

Which of the following should be avoided when taking muscle relaxants? a. grapefruit b. cheeses c. alcohol d. antibiotics

c. alcohol

Which of the following has the potential for cross-reactivity in patients who are allergic to sulfonamides? a. etodolac b. diclofenac c. celecoxib d. ketoprofen

c. celecoxib

Which of the following is a COX-2 inhibitor? a. tramadol b. meloxicam c. celecoxib d. etodolac

c. celecoxib

What drug is used to treat acute attacks of gout? a. febuxostat b. allopurinol c. colchicine d. probenecid

c. colchicine

Which of the following is a drug used to treat gout that is available in oral and injectable dosage forms? a. probenecid b. febuxostat c. colchicine d. sulfasalazine

c. colchicine

An unlabeled use for baclofen (Lioresal) is to treat a. fever. b. headaches. c. hiccups. d. arthritis.

c. hiccups

Which NSAID has an oral liquid form and is suitable for children? a. aspirin b. acetaminophen c. ibuprofenCorrect d. naproxen

c. ibuprofen

Which of the following types of salicylates can be taken daily to reduce the risk of heart attacks and strokes in patients who have a prior history of cardiovascular disease? Select one: a. buffered aspirin b. EC aspirin c. low dose aspirin d. salsalate

c. low dose aspirin

In addition to providing primary drug therapy for arthritis, NSAIDs are commonly used to treat a. GERD. b. hypertension. c. menstrual cramps. d. constipation.

c. menstrual cramps.

Methotrexate is not used to treat a. arthritic conditions. b. cancer. c. pain. d. psoriasis.

c. pain

Patients taking probenecid should not take _____ because they can prevent the excretion of uric acid and can precipitate an attack of gout. a. NSAIDs b. muscle relaxants c. salicylates d. antimalarial drugs

c. salicylates

Which of the following is a common side effect of allopurinol? a. changes in skin color b. neutropenia c. skin rash d. discoloration of urine

c. skin rash

Patients who have an allergy to sulfa drugs or salicylates should avoid which of the following drugs? a. aspirin b. azathioprine c. sulfasalazine d. chloroquine

c. sulfasalazine

Celecoxib has the potential for cross-reactivity in patients who are allergic to which of the following drug classes? a. penicillins b. fluoroquinolones c. sulfonamides d. aminoglycosides

c. sulfonamides

NSAIDs may _____ to reduce fever than other agents, but the effects _____. a. act quicker; last longer b. take longer; wear off sooner c. take longer; last longer d. act quicker; wear off sooner

c. take longer; last longer

A joint is best described as a. the breakdown of bone and release of calcium into the bloodstream. b. an organ that produces movement by contracting. c. the junction between two or more bones of the skeleton. d. noncontractile connective tissue that ties one bone to another bone.

c. the junction between two or more bones of the skeleton.

Naproxen does not go by the brand name a. Anaprox. b. Naprosyn. c. Aleve. d. Advil.

d. Advil.

_____ are the most common drugs used to treat osteoporosis. a. Skeletal muscle relaxants b. Selective estrogen receptor modulators c. NSAIDs d. Bisphosphonates

d. Bisphosphonates

Acetylsalicylic acid (ASA) is the chemical name for what drug? a. ibuprofen b. naproxen c. acetaminophen d. aspirin

d. aspirin

Which of the following drugs is least likely to produce GI irritation at analgesic doses? a. aspirin b. naproxen c. indomethacin d. celecoxib

d. celecoxib

What drug used to treat arthritis has the following dosage forms: patch, tablet, topical, and ophthalmic? a. ketorolac b. ibuprofen c. sulindac d. diclofenac

d. diclofenac

Which of the following is a supplement derived from the exoskeleton of shellfish that is used to improve pain and stiffness from OA? a. willow bark b. poppy seeds c. chondroitin d. glucosamine

d. glucosamine

What NSAID is the most used for gouty arthritis? a. golimumab b. aspirin c. sulfasalazine d. indomethacin

d. indomethacin

Chronic use of narcotics and an NSAID or acetaminophen can lead to a. death. b. cardiovascular disease. c. liver failure. d. kidney failure.

d. kidney failure

What is the most serious adverse effect associated with acetaminophen? a. kidney damage b. brain damage c. GI ulcers d. liver damage

d. liver damage

Acetaminophen doses greater than 4 g (4,000 mg) a day are associated with which of the following? a. kidney failure b. gastrointestinal bleeding c. breathing abnormalities d. liver toxicity

d. liver toxicity

Which of the following drugs may turn urine brown, black, or green? a. cyclobenzaprine b. metaxalone c. diazepam d. methocarbamol

d. methocarbamol

Healthcare workers who are pregnant should avoid or wear gloves when handling a. aspirin. b. acetaminophen. c. ibuprofen. d. misoprostol.

d. misoprostol.

All the following nonsteroidal anti-inflammatory drugs are available in topical formulations except a. ketoprofen. b. ibuprofen. c. diclofenac. d. nabumetone.

d. nabumetone

Oral bisphosphonates should be administered a. with meals. b. without regard to meals. c. while lying down. d. on an empty stomach.

d. on an empty stomach.

What patient should not take misoprostol(Cytotec), a drug sometimes used to counter the gastric irritating effects of NSAIDs? a. patients over 65 years of age b. women c. infants d. pregnant women

d. pregnant women

Which type of arthritis is characterized by inflammation of the joint's synovial membrane? a. gout b. fibromyalgia c. psoriatic arthritis d. rheumatoid arthritis

d. rheumatoid arthritis

Which of the following is not an example of a disease-modifying antirheumatic drug (DMARD)? a. methotrexate b. anakinra c. azathioprine d. tramadol

d. tramadol

Which of the following is true about skeletal muscles? a. found in the stomach b. involuntarily controlled c. found in the heart d. voluntarily controlled

d. voluntary controlled