Week 5 assignment 3
Intracellular receptors usually act by changing gene____in the cell.
expression or transcription
The receptor tyrosine kinase is a transmembrane protein with an __ ligand binding domain and an __ kinase domain.
extracellular; intracellular
When a steroid hormone binds the hormone-binding domain of a steroid hormone receptor, the receptor's conformation changes. As a result of this, the_____protein is released, which exposes the____binding site of the receptor.
inhibitor DNA
RTKs can propagate the original signal by phosphorylating other intracellular targets with their____domain.
kinase or tyrosine kinase
The catalytic site of the receptor tyrosine kinase acts as a protein kinase that adds_____groups to tyrosines.
phosphate or P
Steroid hormone receptors are usually inactive when the hormone that they bind is not present. Why?
Because the DNA-binding domain is blocked by an inhibitor protein
Why can steroid hormones cross the membrane and bind to intracellular receptors?
Because they are non-polar
Examples of steroids include which of the following?
Cortisol Testosterone Estrogen
Which of the following are two ways in which RTKs can propagate the original signal inside the cell?
RTKs can use their kinase domain to phosphorylate intracellular targets. The phosphorylated RTK can interact with other proteins in the cell.
Estrogen, cortisol, and progesterone are examples of which of the following?
Steroids
Which of the following are the two typical locations of intracellular receptors in the cell?
The nucleus The cytoplasm
Which of the following are ways in which intracellular receptors can act?
They can be enzymatic receptors that modify molecules in the cytoplasm. They can act by producing changes in gene expression.
Autophosphorylation occurs when which of the following occurs?
Two receptor-ligand complexes associate and phosphorylate each other
The process of___occurs when two receptor-ligand complexes associate together and phosphorylate each other.
autophosphorylation