BB Exam

anti-c and anti-E

A 25-year-old Caucasian woman required two units of Whole Blood. The antibody screen was positive and the results of the antibody panel are shown above. Which of the following antibodies may be the cause of the positive antibody screen?

survival time

A characteristic of neocytes is it has longer transfusion _____:

2 units

Anti-K and anti-c were found in a patient with colon cancer. How many units of red cells would need to be screened to find two compatible units for surgery? The antigen negative frequency for K and c are 0.91 and 0.20, respectively.

3 to 7 days after transfusion

DHTRs from anamnestic responses usually occur within which time period?

Patient's cells + Ulex europaeus

no agglutination =You are working on a specimen in the laboratory you believe to be a Bombay phenotype. Which of the following reactions would you expect to see?

I

A patient with Mycoplasma pneumonia infection will mostly likely develop a cold autoantibody with specificity to:

1°C or more

A febrile transfusion reaction is defined as a rise in body temperature of ___ occurring in association with the transfusion of blood or components and without any other explanation.

Vicia graminea

A lectin with anti-N specificity can be made from:

Dia

A low-incidence antigen that serves as a useful anthropologic marker for, Mongolian ancestry:

B3

A mixed-field agglutination pattern with anti-B and anti-AB typing sera is characteristic of type:

hemolytic disease of the newborn

A positive DAT may be found in which of the following situations:

Bga

A previously named HLA that is not uncommonly detected on erythrocytes is:

Deferoxamine

An iron chelating agent which is important in lowering the body iron stores of patients with thalassemia:

group A persons

Acquired B antigens have been found in:

Tn polyagglutination

All of the following are microbially associated forms of polyagglutination, EXCEPT:

Febrile transfusion reaction

All paperwork checks on this transfusion reaction are OK. The pre-transfusion sample hast straw-colored plasma. The post-transfusion sample has red-tinged plasma. This is indicative of a (an):

ABO and Rh

Allogeneic donor blood collected and processes from outside sources must have the following tests repeated by the hospital blood bank:

cell suspension

An example of a technical error that can result in an ABO discrepancy is _____ that is too heavy.

DcECe

Arrange the common Rh antigens according to immunogenecity (greatest to least):

Increase in plasma K*

Biochemical changes occur during the shelf life of stores blood. Which of the following is a result of this "storage lesion"?

7 days

Blood donor and recipient samples used in crossmatching must be stored for a minimum of how many days following transfusion?

more than 7 days old

Blood for intrauterine transfusion should be all of the following except:

CMV

Blood products are tested for which virus before being transfused to newborns?

indirect antiglobulin test

Cells carrying a weak D antigen require the use of what test to demonstrate its presence?

IgG

Cold hemagglutinin disease (CHD) is different from paroxysmal cold hemoglobinuria (PCH) becasue the offending antibody in PCH is an ___ antibody unlike the IgM antibody in CHD.

2 to 6°C

Commonly used blood bank antisera should be routinely stored at ______ °C when not in use.

rouleaux

Elevated levels of globulin and fibrinogen, presence of plasma expanders, and of wharton's jely can result in ______ formation or pseudoagglutination.

Platelets

Even though it is properly collected and stored, which of the following will fresh frozen plasma (FFP) not provide?

72 hours

For autologous blood donation, blood should not be drawn from the donor-patient within _____—hours of the time of the anticipated operation or transfusion.

cold and warm

From the reactions given it appears that there is a ____ system and a ____ system reacting.

lymphocytes

Graft-versus-host disease can be a consequence of transfusion if not capable of rejecting them.

antibiotics

Granulocyte transfusions are clinically appropriate for patients who have life-threatening systemic infections that are uncontrolled by:

i antigen

HEMPAS red blood cells are characterized by increased amount of:

Neocytes

Hemochromatosis may be reduced by transfusing:

Bilirubinemia

Hemolytic transfusion reactions result in all the following laboratory finding except:

Partial D

If a D-positive person makes an anti-D, this person is probably:

invalid

If during a Donath-Landsteiner test there is hemolysis in both the test and the control tube at the conclusion of the test, which of the following possible conclusion is most applicable?

3 days

If patient has had a transfusion or has been pregnant within the last 3 months or if the history is unavailable, the sample must be obtained from the patient within __ (days) of schedules transfusion:

4weeks

Immunization for rubella would result in a temporary deferral for:

DI

Mutations in the carrier molecule for this blood group system may result in changes of red blood cell shape in the forms of elliptocytosis, acanthocytosis, or ovalocytosis.

5 to 15 minutes

Incubation period when using low ionic strength saline solution (LISS) medium:

Le (a-b+)

Inheritance of Sese and the Lewis gene produces the following phenotype:

hydatid cyst fluid

Interfering anti-P1 antibody can be removed from a mixture of antibodies with neutralization with:

Yersinia enterocolitica

Of the deaths caused by bacterial contamination of blood components reported to Centers for Disease Control (CDC), most are caused by blood components contaminated by:

PTP

Of the transfusion reaction type listed, which results in thrombocytopenia owing to platelet alloantibody?

30 minutes

Once a unit of blood is removed from a 2-8 degrees C environment, how long can it be left before commencing a transfusion?

24 hours

Once thawed, FFP must be transfused within:

washed red blood cells

Patients with in vivo polyagglutination should be given transfusions of:

drug adsorption

Penicillin given in massive doses has been associated with red cell hemolysis. Which of the classic mechanisms is involved in the haemolytic process?

red blood cell substitute

Perfluorocarbons have been investigated as:

3.0 x 10^11

Platelet concentrates prepared by pheresis should contain how many platelets per uL?

anti-IgG and anti-C3d

Polyspecific AHG reagent contains:

compatible major side crossmatch

Predict compatibility or incompatibility for the following situation, Assume that the patient has a negative antibody screen and auto-control - Patient group B positive, Donor group O positive.

Factor IX deficiency

Prothrombin complex concentrates are used to treat which of the following?

deferred indefinitely

Recipient of human growth hormone would be:

free serum globulins

Red blood cells must be washed in saline at least three times before addition of AHG reagent to remove traces of:

enzyme panel

Running an ____ would help to distinguish between anti-e and anti-Fy' in an antibody mixture.

donor

Specimen needed in the investigation of hemolytic transfusion reaction, except new blood sample from:

ABO

The AB cis genotype is:

Anti-D

The antibody that reacts at 37°C and AHG is:

Anti-Lea

The antibody that reacts in the cold is:

Group B

The cells and serum of a neonate were tested at room temperature: Patient cells with: Anti-A=0, Anti-B =+ | Patient serum with: A1 cells =0, B cells =0. The infant is probably:

Membrane modification

The drug cephalosporin can cause a positive direct antiglobulin test by which of the following mechanisms?

Type 1 precursor chain

The main carriers of A, B, and H in body fluids and secretions:

Standardization

The major advantage of gel technology is:

A1B

Which of the following ABO blood groups contain the least amount of H substance?

Fy(a-b-)

Which of the following Duffy phenotypes Is prevalent in blacks but virtually nonexistent in whites?

platelet concentrates

The most common cause of transfusion-related sepsis is:

two or more FNHTRs

The most common reason for transfusion of leukocyte-poor blood is that recipient has had:

R1r

The most probable Rh genotype for the donor of cell 1 is:

anti-D

The most severe form of HDN is associated with:

Normal (0.9%) saline

Which of the following is usually employed to start an IV line prior to blood transfusion?

Cryoprecipitated AHF

Which of the following would be the component of choice for treatment of von Willebrand's disease?

Elution

The process of separation of antibody from its antigen is known as:

Black

The racial origin of the donor of cell 3 is:

11 g/dL hgb, 33% het

The required hemoglobin and hematocrit for autologous donation should be at least:

Bacterial

This contamination of blood components can occur at the time of phlebotomy, during thawing in water baths, and during component preparation.

4+ 1+ neg 4+

This typing: anti-A _____, anti-B _____, A cells _____, B cells ____ occurs when a patient has an acquired B antigen.

6 to 8 hours

To maximize the number of components derived from one unit of blood, processing must occur within:

allergic

Transfused plasma constituents resulting in immediate erythema, itching and hives best typify which of the following transfusion reactions?

cryoprecipitate

Transmission of viruses in ____ may be eliminated by heating in a liquid form, heating in a lyophilized form, and irradiating with ultraviolet light.

twins

True chimerism occur as result of two cell population are both recognized as self, occurring in:

anti-A, anti-B, anti-H

What antibodies are formed by a Bombay individual?

ABO and Rh typing

What are the pretransfusion requirements for an autologous transfusion?

calcium

What electrolyte may fall in level as a result of citrate toxicity from massive transfusions?

78%

What hematocrit is acceptable for packed RBCs in a closed system?

rr

What is one possible genotype for a patient who develops anti-C antibody?

granulocytes

What is the component of choice for a patient with chronic granulomatous disease?

anti-leukocyte antibody

What may be found in the serum of a person who is exhibiting signs of transfusion-related acute lung injury (TRALI)?

O Rh-negative, packed cells

What type of blood can be given in an emergency transfusion when there is no time to type the recipient's sample?

O Rh-negative, packed cells

What type of blood should be given in an emergency transfusion when there is no time to type the recipient's sample?

incubate 15 to 30 minutes

When a patient's sample shows a discrepancy between forward and reverse grouping with missing or weak reactions, to enhance these reactions, ________ at room temperature or 4°C.

two

When a recessive trait is expressed, it means that ____ genes carrying the trait were present.

decrease in 2, 3—DPG

When blood is stored, there is a "shift to the left". This means hemoglobin oxygen affinity increases owing to a:

A1B

Which among the following ABO blood groups contains the least amount of H substance?

Fya

Which antigen is routinely destroyed by enzymes?

XG

Which blood group system is under control of a gene located at the petite (short) arm of the X chromosome?

anaphylactic

Which listed transfusion reactions is most associated with transfused patients lacking IgA immunoglobulin?

Jk(a-b-)

Which phenotype could not result from the mating of a Jk (a+b+) female and a Jk (atb+) male?

Dithiothreitol and papain

ZZAP is used to remove antibody from sensitized RBCs and to enzyme treat them at the same time. It is a mixture of: