BIO 335 - Methods in Molecular Genetics

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What is a microsatellite?

A short DNA sequence repeated many times in a row

During a researchers in situ hybridization procedure, what causes the probe to stick to the chromosome?

Complementary base pairing in the corresponding gene

The most common method of in situ hybridization uses ______ DNA probes

Fluorescent

The mapping technique that relies on the frequency of recombinant offspring for determination of the distance between genetic loci is ______ mapping

Linkage

A short repetitive DNA sequence, such as dinucleotide sequence repeated many times in a row is called

Microsatellite

A segment of DNA that is located at a specific site along a chromosome and that has properties that allow it to be uniquely identified using molecular tools is called a ______ marker

Molecular

One of the benefits of sequencing the human genome is that it will make it easier to identify genes that cause disease when they are

Mutated

A microsatellite can be amplified by PCR using primers that are located

On both sides of the microsatellite

cytogenetic mapping

Determination of the locations of specific sequences relative to bands on chromosomes

physical mapping

Determining the locations of genes and other DNA sequences using DNA cloning techniques

linkage mapping

Determining the relative locations of genes on a chromosome based on their frequency of genetic recombination

What is the goal of genome sequencing project?

To determine the DNA sequence of the entire genome of a given species

The ability to rapidly sequence large amounts of DNA is called _____ - ______ sequencing

High throughput

One of the goals of the human genome project was to obtain a genetic linkage map of the human genome. This was accomplished by

Identifying millions of genetic markers and their locations on chromosomes

What outcomes have already resulted from the human genome project?

Improved DNA sequencing technology Improvements in software for accessing and analyzing sequence DNA Improvements in cloning technology Sequence data for the 22 human autosomes Sequence data for the human X and Y chromosomes


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