Ch 10 Mitosis/Cell Division MC

10. The mitotic spindles arise from which cell structure? a. centromere b. centrosome c. kinetochore d. cleavage furrow

10 B. centrosome

12. Unpacking of chromosomes and the formation of a new nuclear envelope is a characteristic of which stage of mitosis? a. prometaphase b. metaphase c. anaphase d. telophase

12 D telophase

14. The chromosomes become visible under a light microscope during which stage of mitosis? a. prophase b. prometaphase c. metaphase d. anaphase

14 A prophase

16. At which of the cell-cycle checkpoints do external forces have the greatest influence? a. G1 checkpoint b. G2 checkpoint c. M checkpoint d. G0 checkpoint

16 A G1 checkpoint

18. If the M checkpoint is not cleared, what stage of mitosis will be blocked? a. prophase b. prometaphase c. metaphase d. anaphase

18 D anaphase

5. An organism's traits are determined by the specific combination of inherited _____. a. cells. b. genes. c. proteins. d. chromatids.

b. genes

1. Figure 10.6 Which of the following is the correct order of events in mitosis? a. Sister chromatids line up at the metaphase plate. The kinetochore becomes attached to the mitotic spindle. The nucleus reforms and the cell divides. Cohesin proteins break down and the sister chromatids separate. b. The kinetochore becomes attached to the mitotic spindle. Cohesin proteins break down and the sister chromatids separate. Sister chromatids line up at the metaphase plate. The nucleus reforms and the cell divides. c. The kinetochore becomes attached to the cohesin proteins. Sister chromatids line up at the metaphase plate. The kinetochore breaks down and the sister chromatids separate. The nucleus reforms and the cell divides. d. The kinetochore becomes attached to the mitotic spindle. Sister chromatids line up at the metaphase plate. Cohesin proteins break down and the sister chromatids separate. The nucleus reforms and the cell divides.

1Figure 10.6 D. The kinetochore becomes attached to the mitotic spindle. Sister chromatids line up at the metaphase plate. Cohesin proteins break down and the sister chromatids separate. The nucleus reforms and the cell divides.

20. Many of the negative regulator proteins of the cell cycle were discovered in what type of cells? a. gametes b. cells in G0 c. cancer cells d. stem cells

20 C. cancer cells

22. ___________ are changes to the order of nucleotides in a segment of DNA that codes for a protein. a. Proto-oncogenes b. Tumor suppressor genes c. Gene mutations d. Negative regulators

22 C Gene mutations

24. A mutated gene that codes for an altered version of Cdk that is active in the absence of cyclin is a(n) _____. a. kinase inhibitor. b. tumor suppressor gene. c. proto-oncogene. d. oncogene.

24 D oncogene.

26. Which eukaryotic cell-cycle event is missing in binary fission? a. cell growth b. DNA duplication c. karyokinesis d. cytokinesis

26 C karyokinesis

3. Figure 10.14 Human papillomavirus can cause cervical cancer. The virus encodes E6, a protein that binds p53. Based on this fact and what you know about p53, what effect do you think E6 binding has on p53 activity? a. E6 activates p53 b. E6 inactivates p53 c. E6 mutates p53 d. E6 binding marks p53 for degradation

3 Figure 10.14 D. E6 binding marks p53 for degradation.

4. A diploid cell has_______ the number of chromosomes as a haploid cell. a. one-fourth b. half c. twice d. four times

4 C twice

6. The first level of DNA organization in a eukaryotic cell is maintained by which molecule? a. cohesin b. condensin c. chromatin d. histone

6 D histone

8. Chromosomes are duplicated during what stage of the cell cycle? a. G1 phase b. S phase c. prophase d. prometaphase

8 B. S phase