ch 20 cancer (patho final)

Chemotherapy usually involves a combination of drugs in order to: 1. reduce the adverse effects 2. guarantee that all cancer cells are destroyed 3. be effective in more phases of the cell cycle 4. totally block the mitotic stage

1 ,3 -reduce the adverse effects - be effective in more phases of the cell cycle

High risk factors for cancer include: 1. human papilloma virus 2. chronic irritation and inflammation 3. repeated sun exposure 4. high family incidence a. 2 only b. 1, 3 c. 3, 4 d. 1, 2, 4 e. 1, 2, 3, 4

1,2,3,4 (all the above)

The common local effects of an expanding tumor mass include: 1. obstruction of a tube or duct 2. anemia and weight loss 3. cell necrosis and ulceration 4. tumor markers in the circulation

1,3 -obstruction of a tube or duct -cell necrosis & ulceration

A warning sign of possible cancer would be any of the following EXCEPT: a. persistent, unusual bleeding b. a change in bowel habits c. sudden development of fever, nausea, and diarrhea d. a change in shape, color, or surface of a skin lesion

a sudden development of fever, nausea, & diarrhea

Vomiting frequently follows a chemotherapy treatment because: a. the gastrointestinal tract is irritated b. the chemicals stimulate the emetic center c. the drugs have an unpleasant odor d. a, b e. a, c

a, b -the gasrointestinal tract is irritated -the chemical stimulate the emetic center

The warning signs for cancer include: a. unusual bleeding b. change in bowel habits c. change in a wart or mole (e.g., color) d. a new solid lump, often painless e. all the above are warning signs.

all the above

The process of carcinogenesis usually begins with: a. exposure to promoters causing dysplasia b. development of defective genes c. an irreversible change in the cell DNA d. a single exposure to a known risk factor causing temporary cell damage

an irreversible change in the cell DNA

Benign tumors can often be differentiated from malignant tumors because benign tumors: a. often have systemic effects b. contain cells showing increased mitosis and atypical rapid growth c. are encapsulated and slow-growing d. can metastasize or invade nearby tissue

are encapsulated & slow-growing

Identify the common dose-limiting factor for chemotherapy: a. alopecia b. bone marrow depression c. nausea and vomiting d. weight loss

bone marrow depression

Which of the following is a characteristic of a benign tumor? a. It is unencapsulated and invasive. b. It consists of undifferentiated cells. c. It exerts systemic effects. d. Cells appear relatively normal.

cells appear relatively normal

Select the correct pair representing a malignant tumor and its marker: a. colon cancer: carcinoembryonic antigen (CEA) b. hepatic cancer: CA125, AFP c. prostate cancer: human chorionic gonadotropin (hCG) d. testicular cancer: Philadelphia chromosome

colon cancer: carcinoembryonic antigen (CEA)

Which factor provides the basis for grading of newly diagnosed malignant tumors? a. size of the tumor b. number of metastases c. degree of differentiation of the cells d. number of lymph nodes involved

degree of differentiation of the cells

One reason for staging a malignant tumor at the time of diagnosis is to: a. identify the original cell from which the tumor developed b. locate and identify the primary tumor c. decide the initiating factor for a particular tumor d. determine the best treatment and the prognosis

determine the best tx & prognosis

What type of normal cells are often damaged during chemotherapy and radiation treatments? a. epithelial cells b. skeletal muscle cells c. nerve tissue d. collagen and fibrous tissue

epithelial cells

What would be an external source of ionizing radiation? a. a needle containing a radioisotope implanted beside the tumor b. gamma rays delivered by a cobalt machine c. a dose of a radioactive drug to be ingested d. a fluid containing radioactive material instilled in a body cavity

gamma rays delivered by a cobalt machine

Glucocorticoids are often prescribed during a course of chemotherapy and radiation because: a. glucocorticoids greatly potentiate the effect of chemotherapy b. the immune system is stimulated c. skeletal muscle atrophy will be decreased d. inflammation around the tumor may be reduced

inflammation around the tumor may be reduced

What is a benign neoplasm originating from adipose tissue called? a. Adenoma b. Lipoma c. Fibrosarcoma d. Adenocarcinoma

lipoma

Which term refers to the spread of malignant cells through blood and lymph to distant sites? a. invasiveness b. seeding c. metastasis d. systemic effect

metastasis

Radiation therapy destroys: a. all cells in the tumor at one time b. the cells in the center of the tumor c. primarily rapidly dividing cells d. radioresistant cells

primarily rapidly dividing cells

The term apoptosis refers to: a. programmed cell death b. abnormal or immature cells c. degree of differentiation of cells d. the development of new capillaries in a tumor

programmed cell death

Antiangiogenesis drugs act on a malignant tumor by: a. promoting the immune response and removal of abnormal tumor cells b. blocking hormonal stimulation of tumor cells c. reducing blood flow and nutrient supply to tumor cells d. transporting radioisotopes into the tumor

reducing blood flow & nutrient supply to tumor cells

What are malignant neoplasms arising from connective tissue cells called? a. Carcinomas b. Sarcomas c. Melanomas d. Fibromas

sarcomas

Remission for cancer is generally defined as a period in which: a. chemotherapy cannot be used b. signs and symptoms are absent c. complications are evident d. metastases occur

signs & sx are absent

Why does ovarian cancer have a poor prognosis? a. The ovaries are inaccessible for examination. b. Specific signs rarely appear until after secondary tumors have developed. c. The same tumor markers are present with many types of cancer. d. No effective treatment is available.

specific signs rarely appear until after secondary tumors have developed

Malignant brain tumors: a. metastasize quickly to all parts of the body b. spread first to lungs and bone c. spread to other parts of CNS d. do not metastasize anywhere at any time

spread to other parts of the CNS

A classification process that applies to a specific malignant tumor and describes the extent of the disease at a given time is called: a. seeding b. mutation c. staging d. grading

staging

Which of the following does paraneoplastic syndrome refer to? a. the effects of substances such as hormones secreted by the tumor cells b. severe weight loss and cachexia associated with advanced cancer c. the decreased resistance to infection resulting from malignant tumors d. the effects of multiple metastatic tumors

the effects of substances such as hormones secreted by the tumor cells

The development of neutropenia during chemotherapy for cancer means: a. the cancer cells are being destroyed quickly b. the patient is likely to hemorrhage c. higher doses of chemotherapy could be tolerated by this patient d. the patient is at high risk for infection

the pt is high risk for infection

All of the following are correct statements about skin cancers EXCEPT: a. They are difficult to diagnose and treat. b. They usually develop slowly on the head, neck, or back of individuals with fair skin. c. The number of skin cancer cases is increasing. d. Basal cell carcinoma is the most common form of skin cancer.

they are difficult to dx & treat

Benign tumors in the brain are often life-threatening because they: a. metastasize early in their development b. they create excessive pressure within the skull c. cannot be removed d. cause serious systemic effects

they created excessive pressure within the skull

The most critical adverse effects of chemotherapy and radiation therapy are: a. thrombocytopenia and leucopenia b. headache and lethargy c. nausea and constipation d. alopecia and weight loss

thrombocytopenia & leucopenia