CITI Training

Which of the following is true regarding the IACUC's authority and responsibilities regarding research animal misuse, mistreatment, or noncompliance?

The IACUC has regulatory authority to stop any animal activities to protect either animals or people.

What are the two principal animal research regulatory documents used by the Office of Laboratory Animal Welfare (OLAW)?

The PHS Policy on Humane Care and Use of Laboratory Animals and the Guide for the Care and Use of Laboratory Animals (the Guide).

Which of the following Guides is best used as a source of guidance for animals used in agricultural research and teaching?

The Guide for the Care and Use of Agricultural Animals in Research and Teaching (the Ag Guide)

Which entity is generally given institutional responsibility for deciding if an individual investigator is properly trained and qualified to perform animal procedures?

The IACUC

Regarding studies with infectious agents in animals, as the BSL and ABSL number increases from 1 to 4, what happens to the containment and safeguard practices?

They become more stringent

Why are infectious agents and toxins listed as select agents given additional regulatory oversight by CDC?

They have potential biological warfare uses.

Which of the following organizations must comply with the PHS Policy when utilizing vertebrate animals for research, teaching, or testing?

Those organizations that accept Public Health Service (PHS) or National Science Foundation (NSF) funding.

What is the primary purpose of the "3 Rs" concept?

Urge investigators to minimize use of animals and minimize pain and distress caused by animal research.

Which of the following does not generally represent a good practice to follow when performing infectious disease work in animals?

Work bare-handed to prevent loss of tactile sensation caused by disposable gloves.

Which of the following statements about postoperative care records is false?

Written postoperative care records are not necessary, as long as proper care is provided and treatments are administered.

Which of the following statements is true about the use of carbon dioxide for euthanasia?

Carbon dioxide is acceptable with conditions for euthanasia in those species where aversion or distress can be minimized.

Which of the following statements is true regarding cervical dislocation?

Cervical dislocation may be performed in immature rats (< 200 g) and rabbits.

Which of the following statements is true regarding research antibody production?

Contracting with a commercial enterprise to produce custom antibodies requires IACUC approval.

According to the Guide, social animals should be housed in pairs or groups whenever possible. Which of the following is not a good justification for housing animals individually?

Convenience of the research and husbandry staff

Which of the following would not be accepted by an IACUC as the sole justification for performing multiple major survival surgeries?

Cost savings

According to the Guide, which housing is recommended preferentially for domesticated rodents?

Solid bottom cages with contact bedding

Which of the following is an example of refinement?

The use of newer surgical techniques that result in less tissue trauma.

Which of the following is true of the dog exercise program mandated by the AWR?

The IACUC can exempt an animal for scientific reasons.

Which of the following is true of the nonhuman primate psychological well-being program mandated by the AWR?

The IACUC can exempt an animal for scientific reasons.

Which of these statements is true?

The USDA developed the Animal Welfare Regulations (AWR) to enforce the Animal Welfare Act (AWA).

Which of the following is considered a minor change that would not require formal IACUC review and approval?

A change in personnel.

Which of the following significant changes to a protocol could be administratively approved (in principle) by VVC?

A change in the analgesic agent administered

When must personnel performing animal procedures be properly trained to do so?

Before any procedures are performed

Which of the following items is helpful to the IACUC when reviewing an animal protocol?

Flowcharts that illustrate complex experimental designs.

Animal care and use regulations and guidelines require organizations to provide training in which of the following areas?

Humane methods of animal experimentation

Which of the following justifications for using a particular species would not likely be accepted by the IACUC?

The particular species is inexpensive to buy and maintain.

The NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules apply to which of the following types of experiments?

Inoculation of recombinant infectious agents into animals

Humane endpoint criteria define the conditions under which:

Intervention must occur to remove an animal from a study, sometimes by euthanizing the animal.

Which statement about the Occupational Health and Safety Program is false?

Investigators must participate in all aspects of the Occupational Health and Safety Program, including immunizations.

Which of the following is false concerning prolonged restraint of animals?

It can be justified simply as a convenience for the research staff.

Which of the following activities would place an animal in category E?

Lethal dose experiments in which animals are allowed to die without intervention.

Surgery that penetrates and exposes a body cavity or produces substantial physical impairment is defined as what kind of surgery?

Major

A dedicated surgery suite must be used for which surgery?

Major survival surgery on non-rodent mammals

Who is authorized to overturn a decision by an IACUC to suspend an activity involving animals?

Nobody

The Animal Welfare Regulations (AWR) do not currently apply to which of the following animals?

Non-vertebrates, laboratory mice, and laboratory rats.

What must investigators do prior to making any significant changes in their use of animals?

Obtain IACUC approval.

Which Public Health Service (PHS) organization is responsible for monitoring organizational compliance with PHS Policy?

Office of Laboratory Animal Welfare (OLAW)

Which of the following statements is true if an investigator wants to use a human clinical area for animal research?

Permission should be obtained from the IACUC and clinical administrators responsible for the area.

Which of the following statements about the postoperative period is false?

Postoperative analgesia is not generally needed in rodents.

If an investigator sees an animal that appears to be in immediate danger, what action should be taken first?

Remove the animal from the threat if safe to do so and contact the attending veterinarian or IACUC.

Because they cannot vomit and are not prone to aspiration pneumonia, which of the following animals should not routinely be fasted prior to surgery?

Rodents and rabbits

Blood collections should be spaced far enough apart to prevent which of the following?

Shock due to low blood volume and anemia.

Which of the following is true of AAALAC International?

Sponsors a voluntary accreditation program for animal care and use programs.

Which of the following activities would disqualify an animal from USDA category D?

Studies in which animals experiencing pain are allowed to die without pain relief.

Including which of the following activities in a project would disqualify an animal from USDA category C?

Surgery