Disease state- Erythrocytes- Anemia- Macrocytic

Pernicious anemia refers to cobalamin deficiency that results from a lack of which of the following?

Intrinsic Factor

Which of the following is necessary for the absorption of Vitamin B12:

Intrinsic factor

What is the mechanism that causes megaloblastic anemia?

Interruption of DNA Synthesis

Which of the following is associated with macrocytic anemia?

Fish tapeworm

For which of these conditions or procedures there may be an increased number of megakaryocytes in the bone marrow, but a decreased number of circulating platelets?

Folic acid deficiency

Single erythrocyte inclusions which are large, round, smooth, and purplish-blue staining are most likely:

Howell-Jolly bodies

Which of the following is the most common condition associated with a nonmegaloblastic macrocytic anemia?

Liver disease

Which of the following conditions would have macrocytic red cells?

Liver disease and Vitamin B12 deficiency

Which red cell morphological classification is characteristic of megaloblastic anemia?

Macrocytic

A 52 year old male with a history of alcoholism is admitted to the hospital with severe abdominal pain. A CBC reveals the following results: White blood cells (WBC)15.7 x109/L4.0-10.0 x109/L Red blood cells (RBC)3.9 x1012/L4.2-5.9 x1012/L Hemoglobin14.4 g/dL12-16 g/dL Hematocrit41%37-48% MCV105 fL80-100 fL RDW-CV16.5%11.0-14.0%

Macrocytic, heterogenous (i.e., more variable)

The condition which is highly associated with the oval-macrocytes and hypersegmented neutrophils found in this image is?

Megaloblastic Anemia

In which of the following conditions are Cabot rings most likely to be observed on a Wright-stained peripheral blood smear?

Megaloblastic anemia

In which of the following conditions would you expect to find Howell-Jolly bodies?

Megaloblastic anemia

The presence of an increased number of hypersegmented neutrophils in the peripheral blood, as shown in this image, is an indication of which of the following conditions?

Megaloblastic anemia

What condition would the following abnormal RBCs, such as those shown by the arrow, be seen in?

Megaloblastic anemia

Which of the following conditions is frequently associated with the white blood cell shown?

Megaloblastic anemia

What would the following Schilling test results indicate: Part I: 2% excretion of radioactive vitamin B12 (normal: 5-35%)Part II: 8% excretion of radioactive vitamin B12 after intrinsic factor was given with vitamin B12 (normal: 7-10%).

Pernicious anemia

Which of the following conditions would produce the results listed below in an anemic patient? MCV = 115 fL MCH = 30 pg MCHC = 34 %

Pernicious anemia

Which of the following is considered a macrocytic anemia?

Pernicious anemia

All of the following are associated with RBC macrocytosis EXCEPT?

Thalassemia

Which of the following statements about macrocytes is true?

The cells are typically larger than a resting lymphocyte.

When distinguishing megaloblastic from nonmegaloblastic macrocytic anemia, which of the following is a key difference in red blood cell morphology?

The presence of round macrocytes in nonmegaloblastic anemia.

Conditions suggested by the macrocytes and the neutrophil in the photograph to the right include Folate deficiency and which other condition?

Vitamin B12 deficiency

Which of the following conditions is hypersegmentation of granulocytes most commonly associated with?

Vitamin B12 or Folate deficiency