Growth in length of a long bone

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proliferation zone

cartilage cells undergo mitosis

calcification zone

matrix becomes calcified; cartilage cells die; matrix begins deteriorating

ossification zone

new bone forms

hypertrophic zone

older cartilage cells enlarge

Stage 3

Calcification zone

Stage 2

Hypertrophic zone

Stage 4

Ossification zone

resting state

Pre-growth

Stage 1

Proliferation zone


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