Growth in length of a long bone
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proliferation zone
cartilage cells undergo mitosis
calcification zone
matrix becomes calcified; cartilage cells die; matrix begins deteriorating
ossification zone
new bone forms
hypertrophic zone
older cartilage cells enlarge
Stage 3
Calcification zone
Stage 2
Hypertrophic zone
Stage 4
Ossification zone
resting state
Pre-growth
Stage 1
Proliferation zone
