Inclusion Bodies -- Step 1

Lewy vs Hirano bodies

Lewy = Parkinson's Hirano = Alzheimer's (found in hippocampus)

Cortical lewy vs globose NFTs

Lewy is strongly ubiquitin-positive

Psammoma Bodies

*Seen in:* papillary or papillary-like tumors *MC associations:* Meningiomas (derived from meningothelium), papillary thyroid carcinoma Also seen in: mesothelioma, papillary serous carcinoma of the endometrium and ovary

Motor neuron disease inclusion body (MND)

ALS FTD primary progressive aphasia *Location:* superficial neocortex, dentage gyrus

Psammoma Bodies

Associated with Carney complex 1. AD 2. PKA holoenzyme 3. lentiginous facial pigmentation, myxoma, sertoli cell tumors, endocrine overactivity (Cushing + acromegaly)

Corpora amylacea -- brain (don't confuse with prostate)

Astrocytic inclusion increased with age, neurodegeneration *Location:* Subpial and perivascular; bulb, skull base, spine

Eosinophilic Granular Bodies (EBG)

Gangliogliomas Astrocytomas Pleomorphic Xanthoastrocytoma -- PAS positive

Hirano bodies

Intracytoplasmic *Location:* Hippocampus CA1 actin-related non-specific increase with age *Associated with:* Alzheimers

Lafora body

Intraneuronal inclusions Lofora body disease polyglucosan body disease Myoclonic epilepsy *inheritance:* AR

Fingerprint bodies

PAS (+) Neuronal ceroid lipofuscinosis *Associated with:* Battons, infantile NCL *inheritance:* AR Onset: 4-9 yo -- sz, dementia, blindness, spastic paraplegia; death age 20-30

Corpora amylacea

PAS (+) Ubiquitin (+)

Mucopolysaccharidoses

PAS (+); LFB (+) Water soluble Lysosomal storage Hunter-Hurler; Safillipo Rare in metachromatic

Marinesco bodies

PAS (-); pink on Masson's *Location:* substantia nigra; LC Nonspecific; increased with age *Associated with:* Parkinsons

Lewy Bodies

Parkinson's DLB, LBVAD, MSA, age

Pick bodies

Pick's Fronto-temporal dementia Neuronal loss and gliosis ("knife-edge" atrophy) *location:* neocortex and dentate gyrus

Negri Bodies

Rabies encephalitis Purkinje cells in CA1 region

Verocay bodies

Schwannoma Antoni A areas

MND-inclusion

Silver stain (-) Ubiquitin (+) tau and alpha-synucelin (-) Composition unknown

Pick bodies

Strongly argyrophilic (silver stain) ++ tau +ubiquitin EM-straight filaments

Herring bodies

Swollen axons; incidental *Location:* Posterior pituitary

Granulovacuolar bodies

Tau (+) *Location:* Hippocampus CA1; subiculum Non-specific; increased with age *Associated with:* Alzheimers