Inclusion Bodies -- Step 1
Lewy vs Hirano bodies
Lewy = Parkinson's Hirano = Alzheimer's (found in hippocampus)
Cortical lewy vs globose NFTs
Lewy is strongly ubiquitin-positive
Psammoma Bodies
*Seen in:* papillary or papillary-like tumors *MC associations:* Meningiomas (derived from meningothelium), papillary thyroid carcinoma Also seen in: mesothelioma, papillary serous carcinoma of the endometrium and ovary
Motor neuron disease inclusion body (MND)
ALS FTD primary progressive aphasia *Location:* superficial neocortex, dentage gyrus
Psammoma Bodies
Associated with Carney complex 1. AD 2. PKA holoenzyme 3. lentiginous facial pigmentation, myxoma, sertoli cell tumors, endocrine overactivity (Cushing + acromegaly)
Corpora amylacea -- brain (don't confuse with prostate)
Astrocytic inclusion increased with age, neurodegeneration *Location:* Subpial and perivascular; bulb, skull base, spine
Eosinophilic Granular Bodies (EBG)
Gangliogliomas Astrocytomas Pleomorphic Xanthoastrocytoma -- PAS positive
Hirano bodies
Intracytoplasmic *Location:* Hippocampus CA1 actin-related non-specific increase with age *Associated with:* Alzheimers
Lafora body
Intraneuronal inclusions Lofora body disease polyglucosan body disease Myoclonic epilepsy *inheritance:* AR
Fingerprint bodies
PAS (+) Neuronal ceroid lipofuscinosis *Associated with:* Battons, infantile NCL *inheritance:* AR Onset: 4-9 yo -- sz, dementia, blindness, spastic paraplegia; death age 20-30
Corpora amylacea
PAS (+) Ubiquitin (+)
Mucopolysaccharidoses
PAS (+); LFB (+) Water soluble Lysosomal storage Hunter-Hurler; Safillipo Rare in metachromatic
Marinesco bodies
PAS (-); pink on Masson's *Location:* substantia nigra; LC Nonspecific; increased with age *Associated with:* Parkinsons
Lewy Bodies
Parkinson's DLB, LBVAD, MSA, age
Pick bodies
Pick's Fronto-temporal dementia Neuronal loss and gliosis ("knife-edge" atrophy) *location:* neocortex and dentate gyrus
Negri Bodies
Rabies encephalitis Purkinje cells in CA1 region
Verocay bodies
Schwannoma Antoni A areas
MND-inclusion
Silver stain (-) Ubiquitin (+) tau and alpha-synucelin (-) Composition unknown
Pick bodies
Strongly argyrophilic (silver stain) ++ tau +ubiquitin EM-straight filaments
Herring bodies
Swollen axons; incidental *Location:* Posterior pituitary
Granulovacuolar bodies
Tau (+) *Location:* Hippocampus CA1; subiculum Non-specific; increased with age *Associated with:* Alzheimers
