Insulins- Peak, onset, duration
Rapid acting insulin special considerations
GIve SC only Best 15 min before meals Dont delay eating after admin All avail in pens and approved for pump use
50/50 insulin
Humalog 50/50 Onset- < 15 min Peak- 4-8 hrs Duration- up to 24 hrs Cloudy Avail as pen Take 15 min prior to eating or immed after
Humalog mix 75/25
Humalog mix 75/25 Onset- < 15 min Peak 3-12 hrs Duration- Up to 24 hrs Cloudy 15 min before or immed after
70/30 Insulin
Humulin 70/30 Novolin 70/30 Onset- 30 min Peak- 4-12 hr Duration- Up to 24 hrs Cloudy take 30-40 min prior to eating
Novolog Mix 70/30
Novolog mix 70/30 Onset-< 15 min Peak- 6-12 hrs Duration- Up to 24 hrs Cloudy take 15 min before eating avail as pen
Short Acting insulin Special considerations
Only insulin that can be given IV Cannot be mixed with glargine Routinely mixed with NPH Higher dose higher effect
Long acting Insulins
glargine-Lantus detemir- Levemir Onset- 1-2 hrs Peak- NONE Duration- up to 24 hrs
Rapid Acting
lispro-Humalog aspart-Novolog glulisine-Apidra Onset- < or = 15 min Peak - 0.5-1.5 hrs Duration 3-5 hrs Clear
Victoza
Incretin Onset- Peak 8-12 hrs Duration- 24 hrs Type 2 only
Byetta
Incretin Onset- 30 min Peak- 2 hrs Duration- 10 hrs Type 2 only
Symlin
Incretin Onset-20 minutes Peak & Duration - dose dependent very short half life Can cause severe hypoglycemia
Intermediate Acting
NPH-Novolin N NPH- Humulin N Onset- 1-1.5 hrs Peak 6-8 Hrs Duration 12-16 hrs Cloudy
Short Acting
Regular insulin- Novolin R Regular insulin- Humulin R Onset- 30-60 min Peak- 2-3 hrs Duration- 4-6 hrs Clear
Intermediate acting insulin special considerations
SC only Rotate between palms to mix Freq mixed with regular insulin Can be mixed with reg and stored in fridge in advance-rotate prior to adm
Long acting insulin special considerations
SQ only-Bottle taller and thinner than other insulins Cannot be mixed with other insulins Initial dose 80% of total NPH Taken any time of day as long always that time Often used though not mixed with rapid acting at meal time
