Marek's Disease

Histopathology characteristic of Marek's

Pleomorphic lymphocytes (T cells)

The serotype of the virus that cause Marek's disease

Serotype 1: Gallid herpesvirus 2 (oncogenic)

What is the best control for Marek's?

Vaccine - very successful (3d before hatch) Use in laying birds not broiler due to time course

Two most common clinical signs of Marek's

1. Paralysis 2. Neoplasm

Four most common gross pathology of Marek's

1. Visceral tumor 2. Skin leukosis - enlargement of feather follicles 3. Discolouration of iris 4. Enlargement/yellowing/loss of striation of peripheral nerves

Most susceptible age of Marek's

> 3 weeks old (more common 2-5m)

Marek's etiology

Herpesvirus

Transmission means of Marek's

Horizontal transmission through inhaling feather follicles from air

The virus asso with Marek's, what is the trophism and where does it replicate?

Lymphatic system Replicate in epithelial cells of feather follicles